Special

MmuEX0022978 @ mm10

Exon Skipping

Gene
ENSMUSG00000020080 | Hkdc1
Description
hexokinase domain containing 1 [Source:MGI Symbol;Acc:MGI:2384910]
Coordinates
chr10:62403492-62408714:-
Coord C1 exon
chr10:62408615-62408714
Coord A exon
chr10:62405425-62405608
Coord C2 exon
chr10:62403492-62403647
Length
184 bp
Sequences
Splice sites
3' ss Seq
CTCTCCGGTCCGCTCTCTAGGAA
3' ss Score
10.49
5' ss Seq
GCTGTGAGT
5' ss Score
7.39
Exon sequences
Seq C1 exon
GACCTGGACGTGGACATCCTGGCTTTGGTTAACGACACTGTGGGGACCATGATGACTTGTGCTTATGATGATCCCAACTGTGAAGTCGGCGTTATCATCG
Seq A exon
GAACAGGCACCAACGCGTGTTACATGGAGGACATGAGCAACATCGACCTCGTGGAAGGGGACGAGGGAAGGATGTGTATCAACACGGAGTGGGGGGCCTTTGGGGACGATGGGGCTTTGGAGGACATCCGCACCGAGTTTGACAGAGAGCTGGACCTGGGCTCGCTCAACCCCGGGAAGCAGCT
Seq C2 exon
GTTCGAGAAGATGATCAGCGGGCTGTACATGGGGGAGCTGGTCAGGCTTATCTTGCTGAAGATGGCCAAAGTTGGTCTCCTGTTTGGGGGTGCAAAATCCTCTGCTCTCCATACAAAGGGCAAGATCGAAACACAGCACGTGGCTGCCATGGAGAT
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000020080_CASSETTE2
Average complexity
S*
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0034916=Hexokinase_1=PD(11.2=67.6),PF0372711=Hexokinase_2=PU(3.3=23.5)

							
A:
PF0372711=Hexokinase_2=FE(25.4=100)

							
C2:
PF0372711=Hexokinase_2=FE(21.7=100)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000020277





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm9




Conservation


Human
(hg38)
chr10:69243182-69243365 
HIGH PSI
HsaEX1046583
(HKDC1)
Human
(hg19)
chr10:71002938-71003121 
HIGH PSI
HsaEX6088715
(HKDC1)
Rat
(rn6)
chr20:32038235-32038418 
HIGH PSI
RnoEX6062745
(AABR07045032.1)
Cow
(bosTau6)
chr28:25771112-25771295 
HIGH PSI
BtaEX6105373
(HKDC1)
Chicken
(galGal4)
chr6:10446958-10447141 
ALTERNATIVE
GgaEX0026320
(HKDC1)
Chicken
(galGal3)
chr6:11957311-11957494 
ALTERNATIVE
GgaEX0026320
(E1BRU7_CHICK)
Zebrafish
(danRer10)
chr13:22894651-22894834 
HIGH PSI
DreEX6061144
(hkdc1)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GACCTGGACGTGGACATCCT

				
R: 
CACGTGCTGTGTTTCGATCTTG

				
Band lengths: 
242-426

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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