Special

MmuEX0026837 @ mm10

Exon Skipping

Gene
ENSMUSG00000040249 | Lrp1
Description
low density lipoprotein receptor-related protein 1 [Source:MGI Symbol;Acc:MGI:96828]
Coordinates
chr10:127607946-127612779:-
Coord C1 exon
chr10:127612657-127612779
Coord A exon
chr10:127610343-127610480
Coord C2 exon
chr10:127607946-127608065
Length
138 bp
Sequences
Splice sites
3' ss Seq
TCACTTCTGTTTGCTCCCAGGTC
3' ss Score
11.03
5' ss Seq
GAGGTAAGG
5' ss Score
10.28
Exon sequences
Seq C1 exon
CCCCTAAAACTTGCAGCCCTAAGCAGTTTGCCTGCAGAGACCAAATCACCTGTATCTCAAAGGGCTGGCGGTGTGACGGTGAAAGAGATTGCCCCGACGGCTCTGATGAAGCCCCTGAGATCT
Seq A exon
GTCCACAGAGTAAAGCCCAGAGATGCCCGCCAAATGAGCACAGTTGTCTGGGGACTGAGCTATGTGTCCCCATGTCTCGTCTCTGCAACGGGATCCAGGACTGCATGGATGGCTCAGACGAGGGTGCTCACTGCCGAG
Seq C2 exon
AGCTCCGAGCCAACTGTTCTCGAATGGGTTGTCAACACCATTGTGTACCTACACCCAGTGGGCCCACGTGCTACTGTAACAGCAGCTTCCAGCTGCAGGCAGATGGCAAGACGTGCAAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000040249-'7-5,'7-3,8-5
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
Alternative protein isoforms (Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0005713=Ldl_recept_a=WD(100=95.2)

							
A:
PF0005713=Ldl_recept_a=PD(0.1=0.0),PF0005713=Ldl_recept_a=WD(100=83.0)

							
C2:
PF146701=FXa_inhibition=WD(100=87.8)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000044004





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000113497, ENSMUSP00000113584
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm9




Conservation


Human
(hg38)
chr12:57141374-57141511 
HIGH PSI
HsaEX6067359
(LRP1)
Human
(hg19)
chr12:57535157-57535294 
HIGH PSI
HsaEX6067359
(AC137834.1)
Rat
(rn6)
chr7:70916401-70916538 
RnoEX0050643
(Lrp1)
Cow
(bosTau6)
chr5:56629582-56629719 
HIGH PSI
BtaEX6022022
(LRP1)
Chicken
(galGal4)
chrUn_JH376175:39923-40060 
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
chr11:1663011-1663148 
HIGH PSI
DreEX0005572
(LRP1 (2 of 2))
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
CCCCTAAAACTTGCAGCCCTA

				
R: 
CACGTCTTGCCATCTGCCTG

				
Band lengths: 
238-376

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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