Special

MmuEX0026867 @ mm9

Exon Skipping

Gene
ENSMUSG00000049252 | Lrp1b
Description
low density lipoprotein-related protein 1B (deleted in tumors) [Source:MGI Symbol;Acc:MGI:2151136]
Coordinates
chr2:41362165-41526583:-
Coord C1 exon
chr2:41526421-41526583
Coord A exon
chr2:41366925-41367147
Coord C2 exon
chr2:41362165-41362336
Length
223 bp
Sequences
Splice sites
3' ss Seq
ATTTACTTTTCTTTCAACAGAAA
3' ss Score
9.96
5' ss Seq
CAGGTAAGT
5' ss Score
10.86
Exon sequences
Seq C1 exon
ATGTGGAACAAATGGCATTTGACTGGCTTACCAGAAATATCTACTTCGTGGACCATGTCAGTGACCGGATCTTTGTTTGTAATTTCAATGGCTCTGTGTGTGTCACTCTGATTGAATCGGAGCTTCACAATCCTAAGGCCATAGCAGCAGATCCCATCGCAGG
Seq A exon
AAAACTTTTCTTTACTGACTATGGGAATGTTCCCAAAATAGAGAGATGTGACTTGGATGGGATGAACAGAACAAGGATAGTTTATTCAAAGGCAGAGCAGCCATCGGCCCTAGCTTTGGACCTCGTCAACAGATTGGTTTATTGGGTAGATCTCTACTTGGACTACGTGGGAGTAGTAGACTACCAAGGCAAAAACAGGCATACAATTGTTCAAGGCAGACAG
Seq C2 exon
GTTAAACATCTCTATGGCATAACTGTATTTGAAGATTATTTATATGCAACCAGTTCTGATAACTTCAATATCATACGAATAAACAGATTTAATGGCACTGATATTCACTCAATAATTAAAATGGAGAGTGCTCGAGGAATCCGAACCTATCAGAAGAGAACACAGCCAACAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000049252-'8-10,'8-9,10-10
Average complexity
ME(8_9-9_10[100=99])
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.052
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0005812=Ldl_recept_b=WD(100=74.5)

							
A:
PF0005812=Ldl_recept_b=PU(71.4=40.0)

							
C2:
PF0005812=Ldl_recept_b=PD(23.8=17.2)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000054275f4696A





     
                   









    
Main Skipping Isoform:
ENSMUSP00000054275f4695A





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000054275, ENSMUSP00000129192
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr2:141062051-141062273 
HIGH PSI
HsaEX6015724
(LRP1B)
Human
(hg19)
chr2:141819620-141819842 
HIGH PSI
HsaEX6015724
(LRP1B)
Rat
(rn6)
chr3:26128727-26128949 
Cow
(bosTau6)
chr2:56049969-56050191 
Chicken
(galGal4)
chr7:31558007-31558229 
ALTERNATIVE
GgaEX6043146
(LRP1B)
Chicken
(galGal3)
chr7:33674650-33674872 
HIGH PSI
GgaEX6043146
(LRP1B)
Zebrafish
(danRer10)
chr9:36578293-36578515 
HIGH PSI
DreEX6037459
(lrp1bb)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TGGCATTTGACTGGCTTACCA

				
R: 
TTCGGATTCCTCGAGCACTCT

				
Band lengths: 
296-519

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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