MmuEX6007458 @ mm10
Exon Skipping
Gene
ENSMUSG00000030201 | Lrp6
Description
low density lipoprotein receptor-related protein 6 [Source:MGI Symbol;Acc:MGI:1298218]
Coordinates
chr6:134480376-134485933:-
Coord C1 exon
chr6:134485644-134485933
Coord A exon
chr6:134484214-134484440
Coord C2 exon
chr6:134480376-134480560
Length
227 bp
Sequences
Splice sites
3' ss Seq
TGCAAATTTTATTTTTGCAGACT
3' ss Score
7.92
5' ss Seq
AGGGTAAAT
5' ss Score
5.83
Exon sequences
Seq C1 exon
GTTCTAACCCCTGTGCTGAGGACAATGGAGGATGTAGCCATCTTTGCCTGTACAGGCCTCAGGGGCTTCGATGCGCCTGTCCCATTGGCTTTGAGCTCATCAGTGACATGAAGACATGCATTGTCCCCGAGGCTTTCCTTCTGTTCTCGAGGAGAGCGGATATCAGACGCATATCTTTGGAAACAAACAACAACAATGTGGCCATTCCTCTCACTGGTGTCAAAGAAGCCTCTGCTTTGGATTTTGATGTCACAGACAACAGGATTTACTGGACTGATATATCACTGAAG
Seq A exon
ACTATTAGCAGAGCCTTTATGAATGGCAGTGCACTGGAACATGTGGTAGAGTTTGGCTTAGATTATCCAGAAGGCATGGCAGTGGACTGGCTTGGGAAGAACTTATACTGGGCAGACACAGGAACAAATCGCATTGAGGTATCGAAGTTGGACGGACAGCACCGACAGGTTTTGGTATGGAAAGACCTTGACAGTCCTCGAGCTCTGGCACTGGATCCTGCTGAAGG
Seq C2 exon
GTTTATGTATTGGACTGAGTGGGGAGGCAAGCCTAAGATTGACAGGGCTGCTATGGATGGAAGTGAACGCACTACATTAGTTCCAAATGTAGGCCGAGCAAATGGTCTCACCATCGACTATGCTAAAAGGCGGCTTTACTGGACAGACCTGGACACTAACCTAATAGAATCCTCAGATATGCTCG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000030201-'24-20,'24-19,25-20
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.063
Domain overlap (PFAM):
C1:
PF146701=FXa_inhibition=WD(100=37.1),PF0005812=Ldl_recept_b=PU(24.4=10.3)
A:
PF0005812=Ldl_recept_b=PD(70.7=38.2),PF0005812=Ldl_recept_b=WD(100=53.9),PF0005812=Ldl_recept_b=PU(0.1=0.0)
C2:
PF0005812=Ldl_recept_b=WD(100=65.1),PF0005812=Ldl_recept_b=PU(51.4=30.2)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCCGAGGCTTTCCTTCTGTTC
R:
AGCCGCCTTTTAGCATAGTCG
Band lengths:
300-527
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types