Special

MmuEX6030291 @ mm9

Exon Skipping

Gene
ENSMUSG00000024913 | Lrp5
Description
low density lipoprotein receptor-related protein 5 [Source:MGI Symbol;Acc:MGI:1278315]
Coordinates
chr19:3652133-3686564:-
Coord C1 exon
chr19:3686355-3686564
Coord A exon
chr19:3659244-3659640
Coord C2 exon
chr19:3652133-3652330
Length
397 bp
Sequences
Splice sites
3' ss Seq
ACCCTGTGCTCTGCCCACAGCCT
3' ss Score
10.4
5' ss Seq
TGGGTAAAC
5' ss Score
3.32
Exon sequences
Seq C1 exon
GTCGTCTTGGGCCGCGGCGCCCGAGGCGGGAGCAAGAGGCGCCGGGAGCCGCGAGGATCCACCGCCGCCGCGCGCGCCATGGAGCCCGAGTGAGCGCGCGGCGCTCCCGGCCGCCGGACGACATGGAAACGGCGCCGACCCGGGCCCCTCCGCCGCCGCCGCCGCCGCTGCTGCTGCTGGTGCTGTACTGCAGCTTGGTCCCCGCCGCGG
Seq A exon
CCTCACCGCTCCTGTTGTTTGCCAACCGCCGGGATGTGCGGCTAGTGGATGCCGGCGGAGTGAAGCTGGAGTCCACCATTGTGGCCAGTGGCCTGGAGGATGCAGCTGCTGTAGACTTCCAGTTCTCCAAGGGTGCTGTGTACTGGACAGATGTGAGCGAGGAGGCCATCAAACAGACCTACCTGAACCAGACTGGAGCTGCTGCACAGAACATTGTCATCTCGGGCCTCGTGTCACCTGATGGCCTGGCCTGTGACTGGGTTGGCAAGAAGCTGTACTGGACGGACTCCGAGACCAACCGCATTGAGGTTGCCAACCTCAATGGGACGTCCCGTAAGGTTCTCTTCTGGCAGGACCTGGACCAGCCAAGGGCCATTGCCCTGGATCCTGCACATGG
Seq C2 exon
GTACATGTACTGGACTGACTGGGGGGAAGCACCCCGGATCGAGCGGGCAGGGATGGATGGCAGTACCCGGAAGATCATTGTAGACTCCGACATTTACTGGCCCAATGGGCTGACCATCGACCTGGAGGAACAGAAGCTGTACTGGGCCGATGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCCTTCCG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000024913-'0-2,'0-1,4-2=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.333 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
PF0005812=Ldl_recept_b=WD(100=32.3),PF0005812=Ldl_recept_b=WD(100=30.8),PF0005812=Ldl_recept_b=PU(0.1=0.0)

							
C2:
PF0005812=Ldl_recept_b=WD(100=62.7),PF0005812=Ldl_recept_b=PU(56.4=32.8)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000025856





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000025856f1653A, ENSMUSP00000134983, ENSMUSP00000135654
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr11:68347847-68348243 
HIGH PSI
HsaEX0036446
(LRP5)
Human
(hg19)
chr11:68115315-68115711 
ALTERNATIVE
HsaEX0036446
(LRP5)
Rat
(rn6)
chr1:218891812-218892208 
HIGH PSI
RnoEX0050741
(Lrp5)
Cow
(bosTau6)
chr29:46485251-46485647 
Chicken
(galGal4)
chr5:15725349-15725744 
Chicken
(galGal3)
chr1:74114125-74114266 
Zebrafish
(danRer10)
chr25:10643326-10643526 
HIGH PSI
DreEX6101253
(lrp5)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
CCATGGAGCCCGAGTGAGC

				
R: 
GGAAGGAGCCGTCCAGGTT

				
Band lengths: 
331-728

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]










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