Special

MmuEX6030295 @ mm9

Exon Skipping

Gene
ENSMUSG00000024913 | Lrp5
Description
low density lipoprotein receptor-related protein 5 [Source:MGI Symbol;Acc:MGI:1278315]
Coordinates
chr19:3628273-3647659:-
Coord C1 exon
chr19:3647528-3647659
Coord A exon
chr19:3630074-3630470
Coord C2 exon
chr19:3628273-3628444
Length
397 bp
Sequences
Splice sites
3' ss Seq
CACAGCTTGTATCCCCACAGGGG
3' ss Score
8.42
5' ss Seq
GGGGTAAGG
5' ss Score
8.05
Exon sequences
Seq C1 exon
TCCACACACCATGCGAGGAGGACAACGGTGGCTGTTCCCACCTGTGCCTGCTGTCCCCGAGGGAGCCTTTCTACTCCTGTGCCTGCCCCACTGGTGTGCAGTTGCAGGACAATGGCAAGACGTGCAAGACAG
Seq A exon
GGGCTGAGGAAGTGCTGCTGCTGGCTCGGAGGACAGACCTGAGGAGGATCTCTCTGGACACCCCTGACTTCACAGACATAGTGCTGCAGGTGGGCGACATCCGGCATGCCATTGCCATTGACTACGATCCCCTGGAGGGCTACGTGTACTGGACCGACGATGAGGTGCGGGCTATCCGCAGGGCGTACCTAGATGGCTCAGGTGCGCAGACACTTGTGAACACTGAGATCAATGACCCCGATGGCATTGCTGTGGACTGGGTCGCCCGGAACCTCTACTGGACAGATACAGGCACTGACAGAATTGAGGTGACTCGCCTCAACGGCACCTCCCGAAAGATCCTGGTATCTGAGGACCTGGACGAACCGCGAGCCATTGTGTTGCACCCTGTGATGGG
Seq C2 exon
CCTCATGTACTGGACAGACTGGGGGGAGAACCCCAAAATCGAATGCGCCAACCTAGATGGGAGAGATCGGCATGTCCTGGTGAACACCTCCCTTGGGTGGCCCAACGGACTGGCCCTGGACCTGCAGGAGGGCAAGCTGTACTGGGGGGATGCCAAAACTGATAAAATCGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000024913-'12-8,'12-7,14-8=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.089 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF146701=FXa_inhibition=WD(100=84.4)

							
A:
PF0005812=Ldl_recept_b=WD(100=30.8),PF0005812=Ldl_recept_b=WD(100=30.8),PF0005812=Ldl_recept_b=PU(0.1=0.0)

							
C2:
PF0005812=Ldl_recept_b=WD(100=72.4),PF0005812=Ldl_recept_b=PU(33.3=22.4)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000025856





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000025856f1653A, ENSMUSP00000135654
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr11:68386316-68386712 
HIGH PSI
HsaEX6003460
(LRP5)
Human
(hg19)
chr11:68153784-68154180 
HIGH PSI
HsaEX6003460
(LRP5)
Rat
(rn6)
chr1:218865769-218866165 
HIGH PSI
RnoEX6005904
(Lrp5)
Cow
(bosTau6)
chr29:46521128-46521524 
HIGH PSI
BtaEX6104011
(LRP5)
Chicken
(galGal4)
chr5:15761906-15762302 
HIGH PSI
GgaEX6037377
(LRP5)
Chicken
(galGal3)
chr5:17639682-17640078 
HIGH PSI
GgaEX6037377
(Q5ZKF9_CHICK)
Zebrafish
(danRer10)
chr25:10612255-10612651 
HIGH PSI
DreEX6101257
(lrp5)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TCCACACACCATGCGAGGAG

				
R: 
CGATTTTATCAGTTTTGGCATCCCC

				
Band lengths: 
302-699

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]










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