Special

MmuEX6077104 @ mm10

Exon Skipping

Gene
ENSMUSG00000015468 | Notch4
Description
notch 4 [Source:MGI Symbol;Acc:MGI:107471]
Coordinates
chr17:34583829-34584850:+
Coord C1 exon
chr17:34583829-34584004
Coord A exon
chr17:34584412-34584631
Coord C2 exon
chr17:34584781-34584850
Length
220 bp
Sequences
Splice sites
3' ss Seq
GACTGTCTCTCTCTTACCAGGGC
3' ss Score
11.28
5' ss Seq
TAAGTGAGA
5' ss Score
2.17
Exon sequences
Seq C1 exon
GTTTGTGGTAGTGATGGGAGTGGATCTGTCCCGCTGTGGTCCGGAACATCCTGCGTCCCGCTGCCCCTGGGACTCTGGACTCCTGCTGCGCTTCCTTGCAGCAATGGCAGCAGTGGGAGCTCTGGAGCCCCTGCTGCCTGGACCCTTGCTGGCGGCTCACCCTCAAGCAGGGACCA
Seq A exon
GGCCCTCTGCCAACCAGCTTCCCTGGCCCATTCTATGTTCACCAGTGGTTGGGGTGCTTCTCCTGGCCCTTGGGGCCCTTCTCGTCCTCCAGCTCATTCGGCGACGGCGACGAGAACATGGGGCCCTGTGGCTGCCCCCTGGTTTCATTCGAAGGCCTCAGACACAGCAGGCACCCCACCGGCGGAGGCCCCCACTGGGCGAGGACAACATTGGTCTTAA
Seq C2 exon
GGCACTGAAGCCAGAGGCCGAAGTGGATGAGGATGGAGTGGCCATGTGCTCGGGCCCTGAAGAGGGAGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000015468_CASSETTE7
Average complexity
S*
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.126 A=0.297 C2=0.786
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF076847=NODP=FE(92.2=100)

							
A:
PF076847=NODP=PD(3.1=2.7)

							
C2:
PF076847=NODP=PD(2.3=33.3)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000015612





     
                   









    
Main Skipping Isoform:
ENSMUSP00000133646





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
ENSMUSP00000134497
  



Associated events






Other assemblies


mm9




Conservation


Human
(hg38)
chr6:32198926-32199100 
ALTERNATIVE
HsaEX0043412
(NOTCH4)
Human
(hg19)
chr6:32166703-32166922 
ALTERNATIVE
HsaEX0043412
(NOTCH4)
Rat
(rn6)
chr20:4349944-4350163 
HIGH PSI
RnoEX6061533
(Notch4)
Cow
(bosTau6)
chr23:26995268-26995487 
HIGH PSI
BtaEX6098180
(NOTCH4)
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TGTGGTAGTGATGGGAGTGGA

				
R: 
CTCTTCAGGGCCCGAGCA

				
Band lengths: 
237-457

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 1 annotated functions for this event 


PMID: 16530045
HsaEX0043412
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: inferred by author. ELM ID: ELMI002960; ELM sequence: LWLP; Overlap: FULL


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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