Special

MmuINT0010595 @ mm9

Intron Retention

Gene
ENSMUSG00000000532 | Acvr1b
Description
activin A receptor, type 1B [Source:MGI Symbol;Acc:MGI:1338944]
Coordinates
chr15:101029215-101032576:+
Coord C1 exon
chr15:101029215-101029445
Coord A exon
chr15:101029446-101032408
Coord C2 exon
chr15:101032409-101032576
Length
2963 bp
Sequences
Splice sites
5' ss Seq
AAGGTACTG
5' ss Score
8.56
3' ss Seq
CTTGTCTGTGTTCTCTGCAGATA
3' ss Score
12.85
Exon sequences
Seq C1 exon
GGTTACCCCTTTTTGTCCAGCGCACAGTGGCCCGAACCATTGTTTTACAAGAGATTATCGGCAAGGGCCGGTTCGGGGAAGTATGGCGTGGTCGCTGGAGGGGTGGTGACGTGGCTGTGAAAATCTTCTCTTCTCGTGAAGAACGGTCTTGGTTCCGTGAAGCAGAGATCTACCAGACCGTCATGCTGCGCCATGAAAACATCCTTGGCTTTATTGCTGCTGACAATAAAG
Seq A exon
GTACTGTGTCCCAAAGTCAGTGGCCACTTGTTGGCGCTAGAGAGGCCTGGCTGCTCTGCTCTGCTGCACACAGCAGGTCTGAATAAGACCATAGTTCTAAACCCACTTTAAATGTGGAGCATTTTATGCCAAGATGCTCACACGGAACCTGGGTTATTGCGTAGCTAAGAAGGCCTCCCATGCCCCACAGGCTTTTCTTCCTCTATCCCTTGATTTGCTCTCCGATCTGCACCCAGCATGGCCCCCATTGGGACTCCCGTGTGTTTGTTTTGAAAACTGCTACAATAGGAATTACGTTCTCACCTGCCTGGGCAGGTGGCAGAGACACATACACGGTCTACAACACAGCACAAGCGTTACACACACTGTCGTAGGGAAGCCACCATAAGCAGACACTGGCCTTTCAGTGTCACCTCATAGCTATGAGACTGGTTTCGGTCTGTTTTATACCTAGAGCCCCAGAGCTTCTGCTGCCGGTCCTCCCCCTCCTCTATCCCCTCTCCTTCCCCTCTCTATCCCCTCTCCTTCCCCTCTCTATCCCCTCTCCTTCCCCTCTCTATCCCCTCTCCTTTCCCTCTCTATCCCCTCTCCTCCCTCCTCTTATCTCCTCTCCTCCCCCTCTATCCCCTCTCCTCCCTCCTCTATCCCCTCTCCTCCCCCCCTCTCTCCTCTCTCCTCCCTCCTCTCTCCTCTCTCCTCCCCCCTCTATCCCCTCTCTTTTCTATCCCCTTTCCTCCCCCCCCACCTCGTTTTTTCTCCTTTGTCATAAGGCAGACTAGACATATAGGACAGCCTAGCCACAAATGTACAGTCTCTCTGTCTCAGCCTTTTATATACATGGGAGAAGCAGGGGAGGGGTAGACAGAGACAAGGTTATGCTGGACTTTTGTGCGTGCCCATGCCCGTGTGTGTGTATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTAACACATACTATGTTGTGTGGCCTGTAATTCTAGTTCCAGGGGATATCATGCCCTCTTTTGGCATCTGCTGGTACTTGCATGAATGTACACATAGCCCTACAAAGACACACCATACACACACACCTGGCATTTGGTACCCCTGGAACACAGAAATTATGAGGGCACTGAGTTGTGTTTTAGAAGTGTCTGGCAGTTGTGACACACTTCCCTCTGCAGCACAATGACTAGAGGCTAGTGTCCACAGATGTATGGGGAATGCCAGCTGAGCGTGTTCTTCAGAGTGCTGCGGGGCTGCAGGTCCCTGGCTGCCCAACAGCTGAAGAGCCCTGGGTGTTAGTGCAGGGGAAGAAGAGACGGTCTCAGCCCTCTGAGGAGCTGCTGCTATCCCAGACGTCTTAGAGTCATTAAAAGGCTCCAACTGTCCTATGGCAGGTCATGGCCTCCTCAGAAAGGAGTTACTGGTTAGAATATGGCCCTCTTTGGGGTCAGAGCTGACAAGGTTGAGACATTTCTAGCAGCCAGCCTTTATTGATTCTGGAAGCTTGTATGAGTTGGGATCTGAGTTAGGGCCAGGAAAGGAGGGAGTCAGACCCCTTTGTTCTTGCCTTGTTACCATGATATAGCCAGTGTGAGGCCCTGGGATTAGCACCAGCCTAGAATTTGGAAGCTTTCAGCCCAGTTTCTAATCTTCCTAGCAACAGCAGCAAGCTTAGCCAGATTGATCAGTGTTGCTTTCTCCTCTCCCTGTCCTCCGTCCTGCCACCCCAAAGTGAAAGAGAGGGGTCAGCAAGCTCCCTGCCTTCCACTGCTTTCCTGAAGGGCAAGATGGCCTTTGTGGGAGTGCTCAGAGCATTCCTGGCTCTGCAACAGGGATGCACAAATGGGATCCTTCTGCTCTCATCATGGCCCTTGGCCTGAGAATGGACACCAAGTGGAAGGAGACATTTCCAGTGAGACAGGTGCTGCACTGGGTCATGATCGAGGGAGGAGTGCAGGCAAGAGCGGGCTCTCCTCCTGGGCAGCAGTGGGTGGAGCACGGAGAGCCTCCTGTCAGAGCGAGGAAGCAAGCCATCAATCGGTAACAAACTGAACCTGCACATTCCAGACTTGGCGATAAAGTGGCGCTGCTGAGCATCTTCCTCACTGACTGGGCTACTTGCTTGTCTCTCTAATAAGACCCCACAGCCAAGTGGCGCACGCCTTTAATCCCAGCACAGAGAAGGCAGAGGCAGGTGGATCTCTGAGTTCAAGGCCAGCCTGGTCTATAGAGCTACACAGAGAAACCCTGTCTCAAAAACAAACAAAAAACAAAAACAGGGCTGAAGAGATGGCTCAGTGGTTAAGAACACTGGCTTCTCTTCTAGAGGTCCTGAGTTCAGTTCCCAGCAACTCCATGGTGGCTCACAACCACCTGTAATGGGATCTGATGCCCTCTTCTGGCATATAGGTGTGCATGCAGATAGAGCATTCATACATAAAATAAATAAAACTTAAAAAACAAAATAACACAAATAATGGCAATAACACATAACACTACTACTACTAATAATAATAAAGACACCACGGCCTGAGTGACTTCCAGAGCGGTTTGCTCTGTGCTCGTGGTCCAGATGGTCACAGCCTGTGATGCTGAAACAGGGCCAGGAGCTGAGAGCTCCTATCTTGAGCTACAAGCAGAAGGATGGCTTGTGACCTCTGAAACCCCAAAGAGTGCCCCAGTGATATACTTTGTTTAGCAAGACCCTACCTCCTAGGCTTTCCAAAGAGCCACCCACTGAGGGTCAGGCAGTCAAAGGCCCAAGACAGTTGTGGAGGAGCATCTCAAGCAAACCACCACACACACCTGGGTAAGGGAGTAAGCCTGAGAGAGAGGTGCTCTCTGTCCTCCCTGGAGGCTGCCAGAGATGTGGAGGCAGGAAGTGGCACTGTGTGTAGCACATACCTTCTTCCTTATTGCATAGTGTTCCTTCTATGTGGCCCTTGTCTGTGTTCTCTGCAG
Seq C2 exon
ATAATGGCACCTGGACCCAGCTGTGGCTTGTCTCTGACTATCACGAGCATGGCTCACTGTTTGATTATCTGAACCGCTACACAGTGACCATTGAGGGAATGATTAAGCTAGCCTTGTCTGCAGCCAGTGGTTTGGCACACCTGCATATGGAGATTGTGGGCACTCAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000000532-Acvr1b:NM_007395:4
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact





	

	
ORF disruption upon sequence inclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=NA C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF085157=TGF_beta_GS=PD(37.9=14.1),PF0006920=Pkinase=PU(22.2=82.1)

							
A:
NA

							
C2:
PF0006920=Pkinase=FE(19.4=100)

						

					

				








    
Main Inclusion Isoform:
NA





     
                   









    
Main Skipping Isoform:
ENSMUSP00000000544





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr12:51981200-51983998 
ALTERNATIVE
HsaINT0003350
(ACVR1B)
Human
(hg19)
chr12:52374984-52377782 
ALTERNATIVE
HsaINT0003350
(ACVR1B)
Rat
(rn6)
chr7:142844629-142847651 
ALTERNATIVE
RnoINT0012768
(Acvr1b)
Cow
(bosTau6)
chr5:28045696-28048201 
ALTERNATIVE
BtaINT0013473
(ACVR1B)
Chicken
(galGal4)
chrLGE22C19W28_E50C23:2737-3059 
GgaINT1005394
(ACVR1B)
Chicken
(galGal3)
chrE22C19W28_E50C23:9238-9563 
LOW PSI
GgaINT0000952
(ACVR1B)
Zebrafish
(danRer10)
chr23:27879235-27880649 
LOW PSI
DreINT0025800
(acvr1ba)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
No suggested primer sequences

				
R: 
No suggested primer sequences

				
Band lengths: 

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






Retrieved from "https://vastdb.crg.eu/wiki/Special:VastDB"