Special

FBgn0033159 @ dm6

Biotype
protein_coding
Gene Symbol
Dscam1
Description
The gene Down syndrome cell adhesion molecule 1 is referred to in FlyBase by the symbol DmelDscam1 (CG17800, FBgn0033159). It is a protein_coding_gene from Dmel. It has 76 annotated transcripts and 76 polypeptides (75 unique). Gene sequence location is 2R:7317924..7381899. Its molecular function is described by: identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. It is involved in the biological process described with 16 unique terms, many of which group under: central nervous system development; response to other organism; cell-cell adhesion via plasma-membrane adhesion molecules; nervous system process; developmental growth. 159 alleles are reported. The phenotypes of these alleles manifest in: cell projection; plasma membrane bounded cell projection; neuron projection; mushroom body beta-lobe; larval neuromere. The phenotypic classes of alleles include: increased mortality; cell migration defective; phenotype; behavior defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages.
Coordinates
chr2R:7317924-7381899:-
Assembly

GENOMIC BROWSER[edit]


EXPRESSION VALUES[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)

EVENTS AND AS PROFILES[edit]

Associated events[edit]

Event
Type
Length
Coordinates
Strand
PSI Average
PSI Range
Annotated Functions
Alternative 3'ss
0
NA
-
26.62
31.97
0
Alternative 3'ss
3
chr2R:7322395-7322397
-
73.38
31.97
0
Alternative 5'ss
0
NA
-
64.33
100
0
Alternative 5'ss
12
chr2R:7324570-7324581
-
35.67
100
0
Exon Skipping
78
chr2R:7381315-7381392
-
1.14
48.74
0
Exon Skipping
12
chr2R:7321367-7321378
-
4.76
74.34
0
Exon Skipping
121
chr2R:7353816-7353936
-
2.47
13.85
0
Exon Skipping
162
chr2R:7366805-7366966
-
13.66
37.18
0
Exon Skipping
12
chr2R:7322383-7322394
-
17.03
100
0
Exon Skipping
306
chr2R:7347392-7347697
-
1.99
40.85
0
Exon Skipping
291
chr2R:7343718-7344008
-
2.34
12.51
0
Exon Skipping
299
chr2R:7342583-7342881
-
8.05
44.9
0
Exon Skipping
288
chr2R:7339028-7339315
-
2.4
35.7
0
Exon Skipping
288
chr2R:7337494-7337781
-
1.69
13.76
0
Exon Skipping
288
chr2R:7335716-7336003
-
17.09
66.38
0
Exon Skipping
285
chr2R:7334934-7335218
-
12.39
70
0
Exon Skipping
266
chr2R:7334401-7334666
-
3.82
29.5
0
Exon Skipping
1227
chr2R:7330976-7332202
-
98.43
27.32
0
Exon Skipping
288
chr2R:7346269-7346556
-
1.27
12.27
0
Exon Skipping
168
chr2R:7326617-7326784
-
54.21
90.98
0
Exon Skipping
213
chr2R:7326152-7326364
-
49.59
75.91
0
Exon Skipping
673
chr2R:7325404-7326076
-
1.69
17.23
0
Exon Skipping
150
chr2R:7323819-7323968
-
63.04
100
1
Exon Skipping
291
chr2R:7345876-7346166
-
2.63
25.25
0
Exon Skipping
291
chr2R:7345485-7345775
-
8.44
80.57
0
Exon Skipping
291
chr2R:7344664-7344954
-
2.53
30.15
0
Exon Skipping
291
chr2R:7344279-7344569
-
11.65
43.14
0
Exon Skipping
162
chr2R:7366466-7366627
-
11.85
78.77
0
Exon Skipping
162
chr2R:7365943-7366104
-
8.61
18.45
0
Exon Skipping
171
chr2R:7365312-7365482
-
6.13
17.26
0
Exon Skipping
162
chr2R:7365018-7365179
-
7.57
24.09
0
Exon Skipping
162
chr2R:7364732-7364893
-
6.54
33.1
0
Exon Skipping
162
chr2R:7364456-7364617
-
8.97
28.53
0
Exon Skipping
171
chr2R:7364178-7364348
-
11.61
25.33
0
Exon Skipping
171
chr2R:7363595-7363765
-
7.91
18.37
0
Exon Skipping
159
chr2R:7363332-7363490
-
7.47
25.19
0
Exon Skipping
124
chr2R:7360291-7360414
-
6.07
15.72
0
Exon Skipping
124
chr2R:7358216-7358339
-
2.48
11.69
0
Exon Skipping
127
chr2R:7358003-7358129
-
2.64
17.18
0
Exon Skipping
124
chr2R:7357183-7357306
-
2.6
14.06
0
Exon Skipping
124
chr2R:7356973-7357096
-
4.93
59.47
0
Exon Skipping
124
chr2R:7356527-7356650
-
2.29
13.34
0
Exon Skipping
124
chr2R:7356107-7356230
-
2.61
20.93
0
Exon Skipping
124
chr2R:7355901-7356024
-
1.69
21.59
0
Exon Skipping
124
chr2R:7354882-7355005
-
3.08
10.02
0
Exon Skipping
124
chr2R:7354686-7354809
-
2.33
11.04
0
Exon Skipping
124
chr2R:7354277-7354400
-
2.56
14.04
0
Exon Skipping
127
chr2R:7353566-7353692
-
1.24
12.83
0
Exon Skipping
124
chr2R:7352899-7353022
-
1.41
16.4
0
Exon Skipping
124
chr2R:7351916-7352039
-
2.82
17.48
0
Exon Skipping
121
chr2R:7349393-7349513
-
7.18
12.46
0
Exon Skipping
67
chr2R:7321583-7321649
-
67.29
82.73
0
Intron Retention
613
chr2R:7323969-7324581
-
26.89
100
0
Intron Retention
486
chr2R:7323333-7323818
-
10.56
95.04
0
Intron Retention
910
chr2R:7321650-7322559
-
8.22
85.04
0
Intron Retention
818
chr2R:7320765-7321582
-
13.51
88.06
0
Intron Retention
1421
chr2R:7366967-7368387
-
46.45
97.65
0
Intron Retention
4937
chr2R:7361868-7366804
-
12.16
39.82
0
Intron Retention
7781
chr2R:7353937-7361717
-
26.28
87.88
0
Intron Retention
3279
chr2R:7344570-7347848
-
25.92
96.74
0



Orthologous genes[edit]

Organism Assembly Gene ID Gene Name Orthology Type

Human hg38 ENSG00000143341 HMCN1 4-to-4
Human hg38 ENSG00000148357 HMCN2 4-to-4
Human hg38 ENSG00000171587 DSCAM 4-to-4
Human hg38 ENSG00000177103 DSCAML1 4-to-4
Human hg19 ENSG00000143341 HMCN1 4-to-4
Human hg19 ENSG00000148357 HMCN2 4-to-4
Human hg19 ENSG00000171587 DSCAM 4-to-4
Human hg19 ENSG00000177103 DSCAML1 4-to-4
Mouse mm10 ENSMUSG00000032087 Dscaml1 4-to-4
Mouse mm10 ENSMUSG00000050272 Dscam 4-to-4
Mouse mm10 ENSMUSG00000055632 Hmcn2 4-to-4
Mouse mm10 ENSMUSG00000066842 Hmcn1 4-to-4
Mouse mm9 ENSMUSG00000032087 Dscaml1 4-to-4
Mouse mm9 ENSMUSG00000050272 Dscam 4-to-4
Mouse mm9 ENSMUSG00000055632 Hmcn2 4-to-4
Mouse mm9 ENSMUSG00000066842 Hmcn1 4-to-4
Cow bosTau6 ENSBTAG00000002319 HMCN2 4-to-4
Cow bosTau6 ENSBTAG00000004754 DSCAM 4-to-4
Cow bosTau6 ENSBTAG00000015235 HMCN1 4-to-4
Cow bosTau6 ENSBTAG00000016692 DSCAML1 4-to-4
Chicken galGal4 ENSGALG00000007314 DSCAML1 4-to-3
Chicken galGal4 ENSGALG00000016138 DSCAM 4-to-3
Chicken galGal3 ENSGALG00000007314 DSCAML1 4-to-3
Chicken galGal3 ENSGALG00000016138 DSCAM 4-to-3
Zebrafish danRer10 ENSDARG00000016936 hmcn1 4-to-6
Zebrafish danRer10 ENSDARG00000024865 dscama 4-to-6
Zebrafish danRer10 ENSDARG00000028118 dscamb 4-to-6
Zebrafish danRer10 ENSDARG00000079327 hmcn2 4-to-6
Zebrafish danRer10 ENSDARG00000098057 dscaml1 4-to-6