BtaEX0003405 @ bosTau6
Exon Skipping
Gene
ENSBTAG00000002392 | ANK2
Description
ankyrin 2, neuronal [Source:HGNC Symbol;Acc:HGNC:493]
Coordinates
chr6:13484970-13491960:-
Coord C1 exon
chr6:13491862-13491960
Coord A exon
chr6:13491215-13491313
Coord C2 exon
chr6:13484970-13485167
Length
99 bp
Sequences
Splice sites
3' ss Seq
CTTAAACACACCCTTTACAGAAT
3' ss Score
5.55
5' ss Seq
AAGGTGAGG
5' ss Score
9.16
Exon sequences
Seq C1 exon
AAGGGTTTTACCCCCTTGCACGTAGCTGCCAAGTATGGGAGCCTGGATGTGGCAAAACTTCTCTTGCAACGCCGTGCTGCCGCAGATTCTGCGGGGAAG
Seq A exon
AATGGCCTTACCCCGCTCCATGTTGCTGCTCACTATGACAACCAGAAGGTGGCGCTGCTGTTACTGGAGAAGGGTGCTTCCCCTCACGCCATGGCCAAG
Seq C2 exon
AATGGCTACACTCCTTTACATATTGCTGCCAAGAAGAATCAAATGCAGATAGCTTCCACACTCCTGAGCTACGGAGCAGAGACGAACATCGTGACAAAGCAAGGAGTCACTCCACTCCATCTGGCCTCGCAGGAGGGACACACGGATATGGTCACCTTGCTTCTGGATAAGGGAGCCAATATCCACATGTCAACCAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSBTAG00000002392-'44-46,'44-45,45-46
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.024
Domain overlap (PFAM):
C1:
PF127962=Ank_2=FE(26.7=100)
A:
PF127962=Ank_2=PD(34.4=93.9),PF127962=Ank_2=PU(5.7=12.1)
C2:
PF0002325=Ank=WD(100=50.0),PF127962=Ank_2=PU(29.0=40.9)
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TTTTACCCCCTTGCACGTAGC
R:
CCGTAGCTCAGGAGTGTGGAA
Band lengths:
168-267
Functional annotations
There are 1 annotated functions for this event
PMID: 17178715
Exon 17 (HsaEX0004129) encodes ankyrin repeat 18 of ankyrin-B. Direct Interaction between Ankyrin-B and Na/Ca Exchanger 1 Requires beta-Hairpin Loop Tips of ankyrin Repeats 16-18, and therefore it is expected to be affected by skipping. The function of the isoforms of HsaEX0004129 have not been examined individually.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development