GgaEX0018070 @ galGal4
Exon Skipping
Gene
ENSGALG00000012044 | chAnk2
Description
Uncharacterized protein [Source:UniProtKB/TrEMBL;Acc:F1NG08]
Coordinates
chr4:56418332-56421770:-
Coord C1 exon
chr4:56421672-56421770
Coord A exon
chr4:56421036-56421134
Coord C2 exon
chr4:56418332-56418529
Length
99 bp
Sequences
Splice sites
3' ss Seq
GCCCCTAACCGCCCTTACAGAAC
3' ss Score
8.1
5' ss Seq
AAGGTGAGC
5' ss Score
9.6
Exon sequences
Seq C1 exon
AAGGGATTCACACCGTTGCACGTGGCGGCCAAATATGGGAGCCTGGAAGTGGCAAAGCTCCTCCTGCAGCGTCGTGCCTCTCCTGACTCAGCTGGCAAG
Seq A exon
AACGGCCTCACGCCCCTGCACGTGGCGGCCCATTACGACAACCAGAAGGTGGCGCTGCTGCTGCTGGAGAAGGGCGCCTCGCCCCACGCGACCGCCAAG
Seq C2 exon
AATGGATACACCCCTCTACACATTGCTGCCAAGAAAAATCAGATGCAGATAGCTACCACGCTGTTGAACTATGGGGCCGAGACCAACATTTTGACCAAACAGGGAGTGACGCCACTTCATTTAGCCTCCCAGGGGGGTCACACAGACATGGTGACATTGCTTTTGGAGAAAGGATCCAATATCCATGTGGCAACAAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSGALG00000012044_CASSETTE6
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.121 A=0.212 C2=0.106
Domain overlap (PFAM):
C1:
PF127962=Ank_2=FE(44.4=100)
A:
PF127962=Ank_2=PD(42.5=93.9),PF127962=Ank_2=PU(5.7=12.1)
C2:
PF127962=Ank_2=PD(92.8=97.0),PF127962=Ank_2=PU(4.3=4.5)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GAAGTGGCAAAGCTCCTCCTG
R:
GGAGGCTAAATGAAGTGGCGT
Band lengths:
183-282
Functional annotations
There are 1 annotated functions for this event
PMID: 17178715
Exon 17 (HsaEX0004129) encodes ankyrin repeat 18 of ankyrin-B. Direct Interaction between Ankyrin-B and Na/Ca Exchanger 1 Requires beta-Hairpin Loop Tips of ankyrin Repeats 16-18, and therefore it is expected to be affected by skipping. The function of the isoforms of HsaEX0004129 have not been examined individually.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]