MmuEX0004900 @ mm10
Exon Skipping
Gene
ENSMUSG00000032826 | Ank2
Description
ankyrin 2, brain [Source:MGI Symbol;Acc:MGI:88025]
Coordinates
chr3:127010854-127013337:-
Coord C1 exon
chr3:127013239-127013337
Coord A exon
chr3:127012673-127012771
Coord C2 exon
chr3:127010854-127011051
Length
99 bp
Sequences
Splice sites
3' ss Seq
TTCAAATACCACCTTTACAGAAT
3' ss Score
5.58
5' ss Seq
AAGGTGAGG
5' ss Score
9.16
Exon sequences
Seq C1 exon
AAGGGCTTCACTCCCCTGCATGTAGCAGCCAAGTATGGAAGCCTGGATGTGGCAAAACTTCTCTTGCAACGTCGTGCAGCCGCAGATTCAGCAGGGAAG
Seq A exon
AATGGCCTTACCCCGCTCCATGTTGCTGCTCATTATGACAACCAGAAGGTGGCGCTGTTGCTGCTGGAGAAGGGTGCTTCCCCTCATGCCACGGCCAAG
Seq C2 exon
AATGGCTATACTCCCTTACACATTGCTGCCAAGAAGAATCAGATGCAGATAGCTTCCACACTACTGAACTATGGGGCCGAGACTAACACTGTGACAAAGCAAGGGGTCACTCCACTGCATCTGGCCTCACAAGAGGGGCACACAGACATGGTCACCTTGCTTCTGGACAAAGGAGCCAATATCCACATGTCAACCAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000032826-'58-66,'58-65,59-66
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.024 A=0.091 C2=0.145
Domain overlap (PFAM):
C1:
PF127962=Ank_2=FE(44.4=100)
A:
PF127962=Ank_2=PD(43.1=93.9),PF127962=Ank_2=PU(5.7=12.1)
C2:
PF127962=Ank_2=PD(43.1=47.0),PF127962=Ank_2=PU(29.0=40.9)
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CTTCACTCCCCTGCATGTAGC
R:
AGTCTCGGCCCCATAGTTCAG
Band lengths:
178-277
Functional annotations
There are 1 annotated functions for this event
PMID: 17178715
Exon 17 (HsaEX0004129) encodes ankyrin repeat 18 of ankyrin-B. Direct Interaction between Ankyrin-B and Na/Ca Exchanger 1 Requires beta-Hairpin Loop Tips of ankyrin Repeats 16-18, and therefore it is expected to be affected by skipping. The function of the isoforms of HsaEX0004129 have not been examined individually.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types