RnoEX0009344 @ rn6
Exon Skipping
Gene
ENSRNOG00000011076 | Ank2
Description
ankyrin 2 [Source:RGD Symbol;Acc:620156]
Coordinates
chr2:231314325-231316725:-
Coord C1 exon
chr2:231316627-231316725
Coord A exon
chr2:231315986-231316084
Coord C2 exon
chr2:231314325-231314522
Length
99 bp
Sequences
Splice sites
3' ss Seq
CTCAAATACCACCTTTACAGAAT
3' ss Score
4.88
5' ss Seq
AAGGTGAGG
5' ss Score
9.16
Exon sequences
Seq C1 exon
AAGGGCTTCACTCCCTTGCACGTAGCAGCCAAGTATGGAAGCCTGGATGTGGCAAAACTTCTCTTGCAACGCCGCGCAGCCGCAGATTCAGCAGGGAAG
Seq A exon
AATGGCCTTACCCCGCTCCATGTTGCTGCTCATTATGACAACCAGAAGGTGGCGCTGTTGCTGCTGGAGAAGGGTGCTTCCCCTCATGCCACTGCCAAG
Seq C2 exon
AATGGCTATACTCCTTTACACATTGCTGCCAAGAAGAACCAGATGCAGATAGCTTCCACACTGCTGAACTATGGAGCTGAGACGAACACTGTGACGAAGCAAGGGGTCACTCCACTGCATCTGGCCTCACAAGAGGGGCACACAGACATGGTCACCTTGCTTCTGGAGAAAGGAGCCAACATCCACATGTCAACTAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSRNOG00000011076-'48-40,'48-39,49-40
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.028 A=0.091 C2=0.149
Domain overlap (PFAM):
C1:
PF127962=Ank_2=PU(29.0=81.8)
A:
PF127962=Ank_2=PD(43.1=93.9),PF127962=Ank_2=PU(5.7=12.1)
C2:
PF127962=Ank_2=PD(91.4=97.0)
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GCACGTAGCAGCCAAGTATGG
R:
CACAGTGTTCGTCTCAGCTCC
Band lengths:
175-274
Functional annotations
There are 1 annotated functions for this event
PMID: 17178715
Exon 17 (HsaEX0004129) encodes ankyrin repeat 18 of ankyrin-B. Direct Interaction between Ankyrin-B and Na/Ca Exchanger 1 Requires beta-Hairpin Loop Tips of ankyrin Repeats 16-18, and therefore it is expected to be affected by skipping. The function of the isoforms of HsaEX0004129 have not been examined individually.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]