BtaEX0003428 @ bosTau6
Exon Skipping
Gene
ENSBTAG00000019052 | ANK3
Description
Bos taurus ankyrin 3, node of Ranvier (ankyrin G) (ANK3), mRNA. [Source:RefSeq mRNA;Acc:NM_001105620]
Coordinates
chr28:15906247-15911877:-
Coord C1 exon
chr28:15911771-15911877
Coord A exon
chr28:15909893-15909925
Coord C2 exon
chr28:15906247-15906471
Length
33 bp
Sequences
Splice sites
3' ss Seq
CTTTCTAAATTATTTTGCAGCTA
3' ss Score
8.84
5' ss Seq
AAGGTGATA
5' ss Score
4.18
Exon sequences
Seq C1 exon
CATCTAACATTCACAAGAGAATTTGACTCAGATTCTCTTAGACATTACAGCTGGGCTGCAGATACCTTGGACAATGTCAATCTTGTCTCAAGTCCTGTTCATTCCGG
Seq A exon
CTATTCTTCTCCACTTCCTCAGTATGATTCAAG
Seq C2 exon
GTTTCTGGTTAGCTTTATGGTGGATGCTCGAGGGGGCTCCATGAGGGGAAGCCGTCACCACGGGATGAGGATTATCATTCCTCCACGCAAGTGTACGGCCCCCACCCGCATCACCTGCCGTTTGGTAAAGAGACATAAACTGGCCAACCCACCCCCCATGGTGGAAGGAGAGGGATTAGCCAGTAGACTGGTAGAAATGGGTCCTGCAGGGGCACAATTTTTAGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSBTAG00000019052_MULTIEX2-1/3=C1-2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.017 A=0.000 C2=0.217
Domain overlap (PFAM):
C1:
PF0079115=ZU5=PU(1.0=2.8)
A:
PF0079115=ZU5=PU(1.0=8.3)
C2:
PF0079115=ZU5=FE(90.4=100),PF0079115=ZU5=PU(0.1=0.0)
Main Inclusion Isoform:
ENSBTAT00000025371fB563
Other Inclusion Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GGCTGCAGATACCTTGGACAA
R:
AATCCTCATCCCGTGGTGACG
Band lengths:
127-160
Functional annotations
There are 2 annotated functions for this event
PMID: 22749401
Inclusion decreases interaction with ATP1A1 and CDH1, but not KCNQ2. By LUMIER.
PMID: 29398366
The axon initial segment (AIS), a subcellular structure important for action potential initiation, is diminished upon Rbfox depletion. An Rbfox-regulated splicing switch in ankyrin G (exclusion/inclusion of HsaEX0004144), the AIS interaction hub protein, regulates ankyrin G-beta spectrin affinity and AIS assembly.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development