MmuEX0004934 @ mm10
Exon Skipping
Gene
ENSMUSG00000069601 | Ank3
Description
ankyrin 3, epithelial [Source:MGI Symbol;Acc:MGI:88026]
Coordinates
chr10:69950952-69956150:+
Coord C1 exon
chr10:69950952-69951058
Coord A exon
chr10:69953440-69953472
Coord C2 exon
chr10:69955926-69956150
Length
33 bp
Sequences
Splice sites
3' ss Seq
CTTTCTAAATTATTTTGCAGCTG
3' ss Score
9.4
5' ss Seq
AAGGTGATA
5' ss Score
4.18
Exon sequences
Seq C1 exon
CACCTGACGTTCACGAGGGAGTTTGATTCTGACTCCCTCAGACACTACAGTTGGGCAGCGGACACGTTAGATAATGTGAACCTGGTCTCAAGCCCGGTGCATTCTGG
Seq A exon
CTGCTCGTCTCCGCTGCCTCAGTATGACTCAAG
Seq C2 exon
GTTTCTGGTTAGCTTTATGGTGGACGCGAGAGGGGGCTCCATGCGAGGAAGCCGCCACCACGGGATGCGGATCATCATCCCTCCGCGAAAGTGTACGGCCCCCACCCGCATCACGTGCCGCCTGGTAAAGAGACATAAACTGGCCAACCCACCCCCCATGGTGGAAGGAGAGGGATTAGCCAGTAGGCTGGTAGAAATGGGTCCTGCGGGGGCACAATTTTTAGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000069601_CASSETTE5
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.022 A=0.000 C2=0.225
Domain overlap (PFAM):
C1:
PF0079115=ZU5=PU(1.0=2.8)
A:
PF0079115=ZU5=PU(1.0=8.3)
C2:
PF0079115=ZU5=FE(89.3=100),PF0079115=ZU5=PU(0.1=0.0)
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
ENSMUSP00000061698, ENSMUSP00000090087, ENSMUSP00000090088, ENSMUSP00000090089, ENSMUSP00000090090, ENSMUSP00000138095, ENSMUSP00000138123, ENSMUSP00000138285, ENSMUSP00000138326, ENSMUSP00000138337, ENSMUSP00000138347, ENSMUSP00000138348, ENSMUSP00000138356, ENSMUSP00000138413, ENSMUSP00000138481, ENSMUSP00000138586, ENSMUSP00000138623, ENSMUSP00000138671, ENSMUSP00000138686, ENSMUSP00000138770, ENSMUSP00000151906
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACGTTCACGAGGGAGTTTGAT
R:
GCGTCCACCATAAAGCTAACCA
Band lengths:
128-161
Functional annotations
There are 2 annotated functions for this event
PMID: 22749401
This event
Inclusion decreases interaction with ATP1A1 and CDH1, but not KCNQ2. By LUMIER.
PMID: 29398366
This event
The axon initial segment (AIS), a subcellular structure important for action potential initiation, is diminished upon Rbfox depletion. An Rbfox-regulated splicing switch in ankyrin G (exclusion/inclusion of HsaEX0004144), the AIS interaction hub protein, regulates ankyrin G-beta spectrin affinity and AIS assembly.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types