Special

MmuEX0004934 @ mm9

Exon Skipping

Gene
ENSMUSG00000069601 | Ank3
Description
ankyrin 3, epithelial [Source:MGI Symbol;Acc:MGI:88026]
Coordinates
chr10:69413700-69418898:+
Coord C1 exon
chr10:69413700-69413806
Coord A exon
chr10:69416188-69416220
Coord C2 exon
chr10:69418674-69418898
Length
33 bp
Sequences
Splice sites
3' ss Seq
CTTTCTAAATTATTTTGCAGCTG
3' ss Score
9.4
5' ss Seq
AAGGTGATA
5' ss Score
4.18
Exon sequences
Seq C1 exon
CACCTGACGTTCACGAGGGAGTTTGATTCTGACTCCCTCAGACACTACAGTTGGGCAGCGGACACGTTAGATAATGTGAACCTGGTCTCAAGCCCGGTGCATTCTGG
Seq A exon
CTGCTCGTCTCCGCTGCCTCAGTATGACTCAAG
Seq C2 exon
GTTTCTGGTTAGCTTTATGGTGGACGCGAGAGGGGGCTCCATGCGAGGAAGCCGCCACCACGGGATGCGGATCATCATCCCTCCGCGAAAGTGTACGGCCCCCACCCGCATCACGTGCCGCCTGGTAAAGAGACATAAACTGGCCAACCCACCCCCCATGGTGGAAGGAGAGGGATTAGCCAGTAGGCTGGTAGAAATGGGTCCTGCGGGGGCACAATTTTTAGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000069601_MULTIEX3-1/2=C1-2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
Alternative protein isoforms (No Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.011 A=0.000 C2=0.218
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0079115=ZU5=PU(1.0=2.8)

							
A:
PF0079115=ZU5=PU(1.0=8.3)

							
C2:
PF0079115=ZU5=FE(89.3=100),PF0079115=ZU5=PU(0.1=0.0)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000090090f5390A





     
                   









    
Main Skipping Isoform:
ENSMUSP00000090090f5603A





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
ENSMUSP00000045834, ENSMUSP00000061698, ENSMUSP00000090087, ENSMUSP00000090088, ENSMUSP00000090089, ENSMUSP00000090090, ENSMUSP00000090090f5391A, ENSMUSP00000090090f5392A, ENSMUSP00000090090f5393A, ENSMUSP00000090090f5394A, ENSMUSP00000090090f6290A, ENSMUSP00000090090f6291A
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr10:60111734-60111766 
ALTERNATIVE
HsaEX0004144
(ANK3)
Human
(hg19)
chr10:61871492-61871524 
ALTERNATIVE
HsaEX0004144
(ANK3)
Rat
(rn6)
chr20:20406040-20406072 
ALTERNATIVE
RnoEX0009397
(Ank3)
Cow
(bosTau6)
chr28:15909893-15909925 
ALTERNATIVE
BtaEX0003428
(ANK3)
Chicken
(galGal4)
chr6:8459693-8459725 
ALTERNATIVE
GgaEX0004065
(chAnk3)
Chicken
(galGal3)
chr6:10120604-10120636 
ALTERNATIVE
GgaEX0004065
(Q90717_CHICK)
Zebrafish
(danRer10)
chr17:20722906-20722938 
ALTERNATIVE
DreEX0013115
(ank3a)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
ACGTTCACGAGGGAGTTTGAT

				
R: 
GCGTCCACCATAAAGCTAACCA

				
Band lengths: 
128-161

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 2 annotated functions for this event 


PMID: 22749401
MmuEX0004934
Inclusion decreases interaction with ATP1A1 and CDH1, but not KCNQ2. By LUMIER.


PMID: 29398366
MmuEX0004934
The axon initial segment (AIS), a subcellular structure important for action potential initiation, is diminished upon Rbfox depletion. An Rbfox-regulated splicing switch in ankyrin G (exclusion/inclusion of HsaEX0004144), the AIS interaction hub protein, regulates ankyrin G-beta spectrin affinity and AIS assembly.


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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