GgaEX0004065 @ galGal3
Exon Skipping
Gene
ENSGALG00000003135 | Q90717_CHICK
Description
NA
Coordinates
chr6:10116575-10124456:+
Coord C1 exon
chr6:10116575-10116681
Coord A exon
chr6:10120604-10120636
Coord C2 exon
chr6:10124232-10124456
Length
33 bp
Sequences
Splice sites
3' ss Seq
CTTTCTAAATTATTTTGCAGCTA
3' ss Score
8.84
5' ss Seq
AAGGTGATA
5' ss Score
4.18
Exon sequences
Seq C1 exon
CACCTGACGTTTCAGAGGGAGTTTGATTCTGATTCTCTCAGACACTACAGCTGGGCTGCAGACACCTTGGACAATGTTAACCTTGTTTCAAGTCCCATCCATTCTGG
Seq A exon
CTATTCCTCTCCACTTCCCCAGTATGATTCAAG
Seq C2 exon
TTTCCTGGTTAGTTTTATGGTCGATGCACGTGGGGGTTCGATGAGAGGAAGTCGTCATCATGGAATGAGAATTATCATCCCACCACGCAAATGCACAGCGCCAACCCGCATCACCTGCCGCTTGGTAAAGAGGCATAAGCTGGCCAGCCCACCACCAATGGTTGAAGGAGAAGGATTAGCAAGTAGACTTGTAGAAATGGGGCCGGCAGGGGCACAATTCTTAGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSGALG00000003135_CASSETTE3
Average complexity
S
Mappability confidence:
NA
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.180
Domain overlap (PFAM):
C1:
PF0079115=ZU5=PU(1.0=2.8)
A:
PF0079115=ZU5=PU(1.0=8.3)
C2:
PF0079115=ZU5=FE(91.5=100),PF0079115=ZU5=PU(0.1=0.0)
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TCTCAGACACTACAGCTGGGC
R:
CTTCCTCTCATCGAACCCCCA
Band lengths:
123-156
Functional annotations
There are 2 annotated functions for this event
PMID: 22749401
Inclusion decreases interaction with ATP1A1 and CDH1, but not KCNQ2. By LUMIER.
PMID: 29398366
The axon initial segment (AIS), a subcellular structure important for action potential initiation, is diminished upon Rbfox depletion. An Rbfox-regulated splicing switch in ankyrin G (exclusion/inclusion of HsaEX0004144), the AIS interaction hub protein, regulates ankyrin G-beta spectrin affinity and AIS assembly.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]