DmeEX0002335 @ dm6
Exon Skipping
Gene
FBgn0259734 | CG42388
Description
The gene Nostrin is referred to in FlyBase by the symbol DmelNost (CG42388, FBgn0259734). It is a protein_coding_gene from Dmel. It has 7 annotated transcripts and 7 polypeptides (5 unique). Gene sequence location is X:9030205..9054575. Its molecular function is described by: phospholipid binding; lipid binding. It is involved in the biological process described with: plasma membrane organization; imaginal disc-derived wing hair organization; plasma membrane tubulation; germarium-derived female germ-line cyst encapsulation; regulation of adherens junction organization. 40 alleles are reported. The phenotype of these alleles manifest in: wing hair. The phenotypic classes of alleles include: fertile; flight defective; lethal - all die during embryonic stage; lethal; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages, in adult female stages.
Coordinates
chrX:9040038-9051122:+
Coord C1 exon
chrX:9040038-9040316
Coord A exon
chrX:9049250-9050935
Coord C2 exon
chrX:9051037-9051122
Length
1686 bp
Sequences
Splice sites
3' ss Seq
GTGTCCCATAAATCGAACAGCCG
3' ss Score
2.27
5' ss Seq
GAGGTACAG
5' ss Score
6.62
Exon sequences
Seq C1 exon
CTCGCCAATGCGCGATCATACGGCGTTTTGAAGAGTTTGAGAAGCTCGGCACGTTATGCCAAGGCCAAATCCAAGTCGGCCATTAATCTCAATGCCCATCTGAAGAAGCAGCAGAAGCTGGAGGAAGGACATCCCGAAAAGAAGAGGCAGGATAAGAAAATACTCAGACAGAGTGTCAGTGAGGATCAGCCGATCTATGCGAATGTGGACGAGGTTATACCGATCCATTTAGAACCGGAAACCGGAACCGAAGTCGATGCTCTAATGGGTAATGCACAG
Seq A exon
CCGTCAAAGATGAACCACCTGCGGGTGCACAAATTCAAGCTGGGCGGCAAAGATAATGCCGCCATGGCCGATTTGCCCCAATCGGAAAACACCACCAACAATAACAATAATATCGGAAGCAATAATAATCAAAAAGGCGGTGCAAAAGGATTTCTGGGAAGGATTAAGCGCTACTCAGTGTTGGGAAATAAACTGGGACGTCGTAATCTCGGCAGTATGAATTTGAATCCGCCGAATAATGTCGTTGATAATTCCGTTTCGCCCACTAAACTCCATACTGGAAGCTACAATATGACCGGTAGCCATTCCGATGATCATCGCCTGGAAATCGGAGCTCCGATTTTAATATCGACTACAACATTGGACACCGACCGTTTCGATGTCACGGAGGCGAGACTCAAACAGATTGGCGGCGGCATAGCCCAGACCTCCAGTATAGTAAGAACCCTGACGCCCAGGAGTTCGGATGAGGAGGAGTTTGTGGACGCCAGGAGTAGTCCGCAACAAATGGAAAGGGATGAGGATCTGCAAATCGCTGATGATCAGGTCGAAAAGAACGATCGCGATCAGTATGGTCATCAATTTCAGCTTCCTAAGAAACAACATCGTGAAGAAGAGATGGGGGACTTAAAATATCTAGACGATCTGGAGGAACCAGAACAATTTGAGACGCCCAAACACGAGGTGGAGGAAAAGCTCCTGACTGCCAACCAGGATGTGAAGCGCCCCATAACGCCCATAACCATTGCCATAGATCCCCCAATCAGACGACCACGTATTGCCCGCCAGCAAAGGCAATCGCAATCCGTTCAGAATCTGCATCGCAGCGAACTGAAGGTATACCTGCACAAGTCCAACTCCGTGGCGCTGGACATGAATGTCACGGCTCCGGCAAAGCTGGGCTTGGACTTGAATCTGCCCGAGTTGCCGGAACTCTATGGAGCCAGCGAGCTCAGTTTGGCGGCCAGTGATAATAAGGAAAATCTGCCAGCGGTGAAGCCATCCGCTGAGCGATCGCCCATACCAAATGGTGGCTTCATGGCCCAGCAGCCACATTTCAAGAGCCTAGACTCGTTCCACCTGAACACCCGCTCCCATTCGAATCAGAGCTCCCAACAGAGTTCCCGCCAAAGCTTGGCCTGCAGCAGCAGCAATGGGGAATACGACTTTGATCTGAAGTCGGTGAGCTATCAGAGCCTGAATGCCCAGAATCTGTTCGTTTCGATTGACGAACTGCAGGAGCTAACGCGTCAGATCAACGAAACGGAGGATTTTGGCAAGGAGATCGATCTGGAGTACTGCGCGCATCGCGATCAATTGAGACCCAGTGAACGCAGGATCACCCTGCTGAAGAACAAAAACCAAACGTTGATCAACTTCAATCACAACAAGGAGAAGCTGCGTAAGGGCTGGCACGGCATGAAGCACTGGCTGGGCGAGGAGGGCTCCAAGATTAAGGAGGCAGTGCGTCAACAGACGCCCCTCAAACGTCTGGCCCAATCACGGAGCAATCTTAACCAGTCAACTGCGGATGCCAGTCGCCAGTCAATGTCGCCGGAACGCACTCAACGCGATGTAACCGAGAGCTGTGAGGATGTCACCGAACGCACCGAAATGGAGTCGTCCATGTCGCACCGAAACAGCGAGGAGGATCTGTCGCCGCATGCCAAGCGGTTCAAGGATGAG
Seq C2 exon
GGACAGAACGGCTTCGAGGAACTCCGGCGATATGTGAAGCAGGGCGGTGATTTTAGCAAGGAGCTCATCTTTGTCCTGCAGGAGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0259734_CASSETTE2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.461 A=0.710 C2=0.103
Domain overlap (PFAM):
C1:
PF0061118=FCH=PU(4.5=80.0)
A:
PF0061118=FCH=PU(5.6=0.9)
C2:
PF0061118=FCH=FE(31.5=100)
Main Inclusion Isoform:
FBpp0310014
Main Skipping Isoform:
FBpp0292036
Other Inclusion Isoforms:
FBpp0289277, FBpp0292038
Other Skipping Isoforms:
FBpp0289278
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGCGATCATACGGCGTTTTGA
R:
CCTGCAGGACAAAGATGAGCT
Band lengths:
351-2037
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)