DmeEX0002333 @ dm6
Exon Skipping
Gene
FBgn0259734 | CG42388
Description
The gene Nostrin is referred to in FlyBase by the symbol DmelNost (CG42388, FBgn0259734). It is a protein_coding_gene from Dmel. It has 7 annotated transcripts and 7 polypeptides (5 unique). Gene sequence location is X:9030205..9054575. Its molecular function is described by: phospholipid binding; lipid binding. It is involved in the biological process described with: plasma membrane organization; imaginal disc-derived wing hair organization; plasma membrane tubulation; germarium-derived female germ-line cyst encapsulation; regulation of adherens junction organization. 40 alleles are reported. The phenotype of these alleles manifest in: wing hair. The phenotypic classes of alleles include: fertile; flight defective; lethal - all die during embryonic stage; lethal; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages, in adult female stages.
Coordinates
chrX:9030205-9051122:+
Coord C1 exon
chrX:9030205-9030896
Coord A exon
chrX:9040038-9040316
Coord C2 exon
chrX:9051037-9051122
Length
279 bp
Sequences
Splice sites
3' ss Seq
TCTCTCGCTCTGGAGAAAAGCTC
3' ss Score
-4.44
5' ss Seq
CAGGTAAGC
5' ss Score
9.88
Exon sequences
Seq C1 exon
GCATCTCTGCCTTTTGCTGGCGAGTGCTACAATTGTCGCACGTAATCGTGCTGGCAGTTACGCCTCAGAAAGCAGCCAAAAAAAAAAGAAAAAAAAACGCAGATACAAGATACAAAAGTATCTCGAACACATGCGTTACGCTCAGCTGACTCGTCGTGTGTGTGAGTGTATCGTAGTGTCGTTGTGTGTGTGTGCTAACAAATTGGTTAGATAAATTAAACAAAAACTGTGAAATTCGCGAATCAAAAAAAAAAAAAAAACAAAAGTAAAATAAAAGTTACACAAACGAAATACGCGAAGGAAAAGCGACGAGCTGAAACTGAAAGCAAACAATCAGCCGGGCTGACCAGTAGTAAATGCTTTAAACTTCAATTATAAAATTTAAATTGAAAAAAATAAAAAAAACACATATAGTTCACAATACCGCATCATAATATCCTACCCGCATCCTAACCCCCGCCGCTGGCCAAAATATGTCACAATTCCGCGATAATTCATGG
Seq A exon
CTCGCCAATGCGCGATCATACGGCGTTTTGAAGAGTTTGAGAAGCTCGGCACGTTATGCCAAGGCCAAATCCAAGTCGGCCATTAATCTCAATGCCCATCTGAAGAAGCAGCAGAAGCTGGAGGAAGGACATCCCGAAAAGAAGAGGCAGGATAAGAAAATACTCAGACAGAGTGTCAGTGAGGATCAGCCGATCTATGCGAATGTGGACGAGGTTATACCGATCCATTTAGAACCGGAAACCGGAACCGAAGTCGATGCTCTAATGGGTAATGCACAG
Seq C2 exon
GGACAGAACGGCTTCGAGGAACTCCGGCGATATGTGAAGCAGGGCGGTGATTTTAGCAAGGAGCTCATCTTTGTCCTGCAGGAGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0259734-'0-8,'0-3,5-8
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.461 C2=0.103
Domain overlap (PFAM):
C1:
PF0061118=FCH=PU(7.7=77.8)
A:
PF0061118=FCH=PU(4.5=80.0)
C2:
PF0061118=FCH=FE(31.5=100)
Main Inclusion Isoform:
FBpp0292036
Main Skipping Isoform:
FBpp0292037
Other Inclusion Isoforms:
FBpp0289278, FBpp0310014
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg19)
No conservation detected
Mouse
(mm9)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACGAAATACGCGAAGGAAAAGC
R:
CCTGCAGGACAAAGATGAGCT
Band lengths:
297-576
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)