Special

DmeEX0008767 @ dm6

Exon Skipping

Gene
FBgn0015519 | nAChRalpha3
Description
The gene nicotinic Acetylcholine Receptor alpha3 is referred to in FlyBase by the symbol Dmel AChRalpha3 (CG2302, FBgn0015519). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (1 unique). Gene sequence location is X:8276200..8367169. Its molecular function is described by: acetylcholine-gated cation-selective channel activity; neurotransmitter receptor activity; acetylcholine receptor activity. It is involved in the biological process described with 6 unique terms, many of which group under: transport; localization; biological regulation; signaling; system process. 25 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: sleep defective; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.
Coordinates
chrX:8307006-8365746:-
Coord C1 exon
chrX:8365490-8365746
Coord A exon
chrX:8329349-8330141
Coord C2 exon
chrX:8307006-8307300
Length
793 bp
Sequences
Splice sites
3' ss Seq
AATGTGTCCTTTCCTTCCAGGAC
3' ss Score
12.27
5' ss Seq
CAAGTAAGT
5' ss Score
10.08
Exon sequences
Seq C1 exon
GCTGAAACTTCAAAACAAATATTGGAAAATTCCGAATAAAAAAAGGTGTGCCAGTTAGCCGAAGGAACCGAATGCAGATTGAAAGCTAAAGTTCGAGGAAGCCAACAGGAACCAAAACAAGGAAGCGAGCCCCTGTCCGTGCGAAGGACCTCCTGGGTCTGTGTGCGTGTGTGCGTGTGTGGGTGCGGCGACACCACTACCACTACCGCTATCACTACCACTATAGCAGCATCGGGCGAAATACTTTTTGTGCCAAG
Seq A exon
GACTCGCCCTTTGTCTATCTATACCACTCCCCTTGCACTCTTCGCGGAATAACGTGGAACAAATGAAGGAGGAAGCGCAGGAATGAGGCGATGTGAAGCAAAAGGACAACGAGGACAGCAAGGAACACAACAAAGGCAAAACCGGAAGAAGGCCACCAAATTGAAGAACACACACATTTGAAGAATTTTAATCGAAAACTGCCAAGAAACAAGTATATTTACAAATATATTTATATACCTTGTAAGCCAAAAAAAAAAAACAAAAATAAGAAAAAAACGACCGTACATTAATAGATCTAAAATATATAGATACATATATAGAGAAATATGTTATATTTACTATGAAATCGAGGAGCATGGAAGCGATACCCAGAATAATAATCGATGTAAATAAATGCTGCCAATTCGATTACACTGCGAATTAAGAACTGCAACTGAGATGCATAGAACGCACAACAACAATCCCAGAAATACCAGGAATCCACAATCCATGAAGAGAAAGTTCACTTTTCCCGCGACAGCTGCGCCTGCGCCTTAAAAACTAGACATAAACATATATATATATATATATCGTATCGATCTTGGAACTATTAAATTGAAAGGATTGGAGCCGCCAGAGCCGAGGATTATATATATATATATAGTCATATATATATATATATATATAGAGCGAGAGAGAGAGACGGGGCAGATCCACCACCGCAGCACAGGCAAAAAAAGCGTGCAGAGGGAAATGAGATGAAGTGGTTTCAAGTGACCATAGATATGATTCTTGTGCTTTCATTTATATCAA
Seq C2 exon
GCAGCACAGCGAATCCGGATGCGAAACGATTGTACGACGATTTGCTGAGCAACTACAACAAACTGGTACGACCGGTGGTCAATGTGACGGACGCGCTCACCGTTCGCATCAAGCTGAAGCTATCGCAACTGATCGATGTCAATCTGAAGAACCAGATAATGACCACCAATCTGTGGGTGGAGCAGTCCTGGTACGACTACAAGCTCAAGTGGGAGCCCAAGGAGTATGGCGGCGTCGAGATGCTTCACGTGCCCTCCGATCACATCTGGCGTCCGGACATCGTTCTCTACAACAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0015519-'2-4,'2-3,3-4
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact

Alternative protein isoforms (Ref, Alt. ATG (>10 exons))

No structure available
Features
Disorder rate (Iupred):
  C1=NA A=0.000 C2=0.000
Domain overlap (PFAM):

C1:
NA
A:
NO
C2:
PF0293118=Neur_chan_LBD=PU(42.1=91.9)


Main Inclusion Isoform:
FBpp0288426


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
FBpp0308714


Other Skipping Isoforms:
NA
Associated events
Conservation
Mouse
(mm9)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AGTTCGAGGAAGCCAACAGGA
R:
GACTGCTCCACCCACAGATTG
Band lengths:
355-1148
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)