DmeEX6011725 @ dm6
Exon Skipping
Gene
FBgn0034276 | Sardh
Description
The gene Sarcosine dehydrogenase is referred to in FlyBase by the symbol DmelSardh (CG6385, FBgn0034276). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is 2R:17753555..17756422. Its molecular function is described by: oxidoreductase activity; sarcosine dehydrogenase activity. It is involved in the biological process described with: sarcosine catabolic process; oxidation-reduction process; S-adenosylmethionine cycle. 6 alleles are reported. No phenotypic data is available. The phenotypic class of alleles includes: viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during early larval stages.
Coordinates
chr2R:17753555-17756422:-
Coord C1 exon
chr2R:17754801-17756422
Coord A exon
chr2R:17754605-17754747
Coord C2 exon
chr2R:17753555-17754539
Length
143 bp
Sequences
Splice sites
3' ss Seq
TAATGATATATATCTTTCAGATC
3' ss Score
8.15
5' ss Seq
CAAGTAAGA
5' ss Score
7.61
Exon sequences
Seq C1 exon
TGATGGGTCCGGATCCCAACCTAGATGGGCTCTACCACAATTGTGGCTTCAATTCAGCGGGCATGATGTTTGGTGGTGGTTGCGGAGAGCAGACCGCCTTGTGGGTCATCCAAGGTCAACCGGACCTGCCCATGTTTGGCTTCGATCTGCGCAGATTCACCCAGGAGCAGGGCAAAGCCATTCAGTGGATTAGGGAGAAGTCGCACGAGAGCTACGTGAAGAACTACAGCATGGTCTTCAAGTATGATCAACCACTGGCGGGTCGTGATTTCCAAAAGGATCCACTTCACGACGAGATGATGAAGGCAGGCGCCGTAATGGAGGAGAAGCAGGGTTGGGAACGGCCTGGTTTCTTCCTGCCCACCGGTTCCAAGAAGGCGGTGGTTCAGCCCTATGACTGGTACGGAAGCTATGTCCACCAGAGGCACAAGGACAGCGAGTACGAGAGAGTTCTGGATGGGGATCTTCACTACAGCCGCTTCTCGGAGTACCACGATCTC
Seq A exon
ATCGGTTCGGAGGCCCTGGCATGTCGCAATAACGCCGTGGTCTTTAACATGAGCTACTTCGCCAAGCTGCTTCTAGATGGTCCACAGGCCCAGGAGGCCGCTGACTGGCTATTCTCCGCCAATACCAACAGGGATCCCAGCAA
Seq C2 exon
AACTGTCTACACCTGTGCTCTAAACGATGCCGGCGGAGTGGAGGCGGATGTGACCATTTCCCGCCTTGCTCCCGGTTCTGGAGAGGTCTACAATCCCAAGATCAATGGCCAGGGCTTTTATATTGTGGCTGGCGGCGCTTCTGCCTTCTACACTTACAGTGTTTTGCTGGCAGAGATCCGTCGAAAAGGATTCAATGCGAGCCTCAAGGATCTGACTGCCGAATTGGGTGTGATTTCTATTCAAGGACCAAACAGCCGAAAGATCCTGCAGCCCCTCATCGACTGTGATCTGTCCGATGAGCACGTAGCTCCCAACAGCACTCGATTAGCCAAATTCGGTGATGTGGGTCTCCGTTTGCTGCGGGTCAGCTTTGTGGGAGAACTGGGCTACGAGCTTCATGTGCCCAAGAAGGATTGTGCTGCCGTCTATCGGAGTCTGATGAAAGCGGGAGCTGGAGAGGATTTGCGCAATGCTGGCTACCGTTCCCTTTACTCCCTCA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0034276-'0-1,'0-0,2-1=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.040 A=0.000 C2=0.025
Domain overlap (PFAM):
C1:
PF0126619=DAO=WD(100=67.9)
A:
PF0157116=GCV_T=PU(14.9=70.8)
C2:
PF0157116=GCV_T=PD(84.6=59.9),PF086696=GCV_T_C=WD(100=30.7)
Main Inclusion Isoform:
FBpp0088528
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
GGACAGCGAGTACGAGAGAGT
R:
GACGGATCTCTGCCAGCAAAA
Band lengths:
252-395
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)