DreEX0003164 @ danRer10
Exon Skipping
Gene
ENSDARG00000009026 | CR388002.1
Description
Uncharacterized protein [Source:UniProtKB/TrEMBL;Acc:E7F4G7]
Coordinates
chr1:13421623-13422583:+
Coord C1 exon
chr1:13421623-13421721
Coord A exon
chr1:13422066-13422164
Coord C2 exon
chr1:13422386-13422583
Length
99 bp
Sequences
Splice sites
3' ss Seq
ATTTTTTATTTCTAAACCAGTAC
3' ss Score
4.75
5' ss Seq
AAGGTACTA
5' ss Score
7.52
Exon sequences
Seq C1 exon
AAAGGCTTCACTCCTCTACATGTTGCTGCTAAGTATGGAAGCCTGGATGTGGCAAAACTCCTTCTACAGCGGAGAGCACTTCTTGATGACGCTGGAAAG
Seq A exon
TACGGCCTCACCCCTCTTCATGTAGCTGCTCACTATGATAACCAGCAGGTGGCGCTGATGCTCTTGGATAAAGGTGCCTCACCTCATGCTACTGCTAAG
Seq C2 exon
AATGGCTACACACCTCTCCATATTGCGGCGAAGAAGAACCAGACTCAGATCGCCTCTGCGCTACTTCAGTATGGTGCAGAGACCAATGCACTGACAAAGCAGGGAGTGAGTCCTCTACACCTGGCATCTCAGGAGGGACACACCGAGATGGCAGCCCTACTGCTGGAGAGAGGAGCACACGTCAACGCTGCCACTAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSDARG00000009026-'19-20,'19-18,20-20
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.030 C2=0.227
Domain overlap (PFAM):
C1:
PF127962=Ank_2=PU(28.7=81.8)
A:
PF127962=Ank_2=FE(34.0=100)
C2:
PF127962=Ank_2=PD(34.0=48.5),PF0002325=Ank=WD(100=50.0)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCTGGATGTGGCAAAACTCCT
R:
AGGACTCACTCCCTGCTTTGT
Band lengths:
172-271
Functional annotations
There are 1 annotated functions for this event
PMID: 17178715
Exon 17 (HsaEX0004129) encodes ankyrin repeat 18 of ankyrin-B. Direct Interaction between Ankyrin-B and Na/Ca Exchanger 1 Requires beta-Hairpin Loop Tips of ankyrin Repeats 16-18, and therefore it is expected to be affected by skipping. The function of the isoforms of HsaEX0004129 have not been examined individually.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]