DreEX0013122 @ danRer10
Exon Skipping
Gene
ENSDARG00000061736 | ank3a
Description
ankyrin 3a [Source:ZFIN;Acc:ZDB-GENE-060621-1]
Coordinates
chr17:20684674-20688867:-
Coord C1 exon
chr17:20688802-20688867
Coord A exon
chr17:20686490-20686573
Coord C2 exon
chr17:20684674-20684760
Length
84 bp
Sequences
Splice sites
3' ss Seq
TAAGCGCTCTTTTGCTTTAGGGA
3' ss Score
8.57
5' ss Seq
AAAGTAACT
5' ss Score
4.33
Exon sequences
Seq C1 exon
CACCGTGGCCTGGATGAAGAGCGCACTGTCACCACCAAGGTGTTTCGTAGACGTCTCATTCTCAAG
Seq A exon
GGAGAGGAGGCACGAAACATTCCTGCCGAGTCAGTTTCAGAGGAACAGTTTATTGATGAAGATGGAAACATCATCACTAGAAAA
Seq C2 exon
GGAGACATTTCCAAGGCGAGGAAGAAGGAAGACAAACGTTCAGAAAGAAAACATCATTCGTAGATGTGGCTTCATGACTATAGACAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSDARG00000061736_MULTIEX1-4/6=3-6
Average complexity
C3
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.955 A=0.821 C2=1.000
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Other Skipping Isoforms:
NA
Associated events
Conservation
Mouse
(mm9)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACCGTGGCCTGGATGAAGAG
R:
CTGTCTATAGTCATGAAGCCACA
Band lengths:
152-236
Functional annotations
There are 1 annotated functions for this event
PMID: 21223964
Ankyrins-G coimmunoprecipitated with plectin and filamin C from skeletal muscle tissue extracts. Muscle-specific OTBD domain (coordinated inclusion of MmuEX1003810, MmuEX1003809, MmuEX0004908) is required for ankyrin-G binding to plectin and filamin C. Isoforms are differentially expressed during myogenesis.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]