DreEX6098925 @ danRer10
Exon Skipping
Gene
ENSDARG00000001734 | fkbp8
Description
FK506 binding protein 8 [Source:ZFIN;Acc:ZDB-GENE-040426-1849]
Coordinates
chr22:20919620-20925470:-
Coord C1 exon
chr22:20925400-20925470
Coord A exon
chr22:20921150-20921417
Coord C2 exon
chr22:20919620-20919789
Length
268 bp
Sequences
Splice sites
3' ss Seq
AAACATGTTATTTGTCTCAGATG
3' ss Score
6.11
5' ss Seq
TAGGTACAC
5' ss Score
4.06
Exon sequences
Seq C1 exon
CAGAGATTGATCTTGTGTTGTTGTGAAAGTTGTTGCTGCGCTGCTCTGAGGTGTATTTTCTTCTCACTGCG
Seq A exon
ATGGCGGACAGTGATGTTGTGAATGGCTCTGCGGATGACCACGAGGTGGCGCCGTTGGCTAAGAAATCTGCTGGCGCTTCACTGCTGGACAGCAGAGAAGACTTTGAGATGCTGGAACACTTGGAGGATGACGTGGATGACGATCTCCCGCCTTTAGAAGATGCAGGTGGAGGAAAGAAGAAGAGCAGTCCTGCTAAAGACCCTGCAAAAGAAGACAAATCTGCAGAAAGTCCTTCTGCAGAACCAGAAGAGTGGCTGGATGTTTTAG
Seq C2 exon
GAAATGGGCAGCTGAGAAAGAAAGTTCTGGAAGCTGGAGCAGGTCCAGACAGCAGACCACAGAAGGGCCAGAATGTCACAATTCATCTTAAAACTGCTCTTACTAATGGAACTGTGGTAGACGAGCTGAAAGATTTATCATTTACACTTGGGGATGGGGATGTCCTTCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSDARG00000001734-'1-1,'1-0,4-1=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=NA A=0.978 C2=0.386
Domain overlap (PFAM):
C1:
NA
A:
NO
C2:
PF0025423=FKBP_C=PU(45.6=71.9)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CAGAGATTGATCTTGTGTTGTTGTGA
R:
GAAGGACATCCCCATCCCCAA
Band lengths:
239-507
Functional annotations
There are 2 annotated functions for this event
PMID: 19546213
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: affinity chromatography technology, anti tag coimmunoprecipitation, colocalization, competition binding, detection by mass spectrometry, fluorescence polarization spectroscopy, fluorescent resonance energy transfer, glutathione s tranferase tag, isothermal titration calorimetry, mutation analysis, protein array, pull down, subcellular preparation. ELM ID: ELMI002479; ELM sequence: LPPLE; Overlap: FULL
PMID: 23413029
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: affinity chromatography technology, anti tag coimmunoprecipitation, colocalization, competition binding, detection by mass spectrometry, fluorescence polarization spectroscopy, fluorescent resonance energy transfer, glutathione s tranferase tag, isothermal titration calorimetry, mutation analysis, protein array, pull down, subcellular preparation. ELM ID: ELMI002479; ELM sequence: LPPLE; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]