HsaEX6093994 @ hg19
Exon Skipping
Gene
ENSG00000105701 | FKBP8
Description
FK506 binding protein 8, 38kDa [Source:HGNC Symbol;Acc:3724]
Coordinates
chr19:18650361-18654383:-
Coord C1 exon
chr19:18654296-18654383
Coord A exon
chr19:18652489-18652805
Coord C2 exon
chr19:18650361-18650530
Length
317 bp
Sequences
Splice sites
3' ss Seq
TCTCTGCCCCCCACTTCCAGGGC
3' ss Score
11.49
5' ss Seq
TGGGTAAGG
5' ss Score
9.08
Exon sequences
Seq C1 exon
GGCCGAACCTGGTTCCCGAGGCGCGGCGGCCGCGGCTGGGGGCGGGGAGGGGGGCGCAGGACCCCAAGTGGGGGTCCCGGAGCCAGAG
Seq A exon
GGCCAATTCCTGTCCCCCCAGCAGCATGGCATCGTGTGCTGAACCCTCTGAGCCCTCTGCCCCACTGCCCGCCGGGGTCCCACCGCTCGAGGACTTCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGAGGAGGAGGAAGAGGAGGAAGAGGATGACCTGAGTGAGCTGCCACCGCTGGAGGACATGGGACAACCCCCGGCGGAGGAGGCTGAGCAGCCTGGGGCCCTGGCCCGAGAGTTCCTTGCTGCCATGGAGCCCGAGCCCGCCCCAGCCCCGGCCCCAGAAGAGTGGCTGGACATTCTGG
Seq C2 exon
GGAACGGGCTGTTGAGGAAGAAGACGCTGGTCCCAGGGCCGCCAGGTTCGAGCCGCCCGGTCAAGGGCCAGGTGGTCACCGTACATCTGCAGACGTCGCTGGAGAATGGCACACGGGTGCAGGAGGAGCCGGAGCTGGTGTTCACTCTGGGTGACTGTGACGTCATCCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000105701-'0-1,'0-0,2-1=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion (Ref, Alt. ATG (<=10 exons))
No structure available
Features
Disorder rate (Iupred):
C1=NA A=0.980 C2=0.649
Domain overlap (PFAM):
C1:
NA
A:
NO
C2:
PF0025423=FKBP_C=PU(45.6=71.9)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCGAACCTGGTTCCCGAGG
R:
TGACGTCACAGTCACCCAGAG
Band lengths:
251-568
Functional annotations
There are 2 annotated functions for this event
PMID: 19546213
This event
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: affinity chromatography technology, anti tag coimmunoprecipitation, colocalization, competition binding, detection by mass spectrometry, fluorescence polarization spectroscopy, fluorescent resonance energy transfer, glutathione s tranferase tag, isothermal titration calorimetry, mutation analysis, protein array, pull down, subcellular preparation. ELM ID: ELMI002479; ELM sequence: LPPLE; Overlap: FULL
PMID: 23413029
This event
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: affinity chromatography technology, anti tag coimmunoprecipitation, colocalization, competition binding, detection by mass spectrometry, fluorescence polarization spectroscopy, fluorescent resonance energy transfer, glutathione s tranferase tag, isothermal titration calorimetry, mutation analysis, protein array, pull down, subcellular preparation. ELM ID: ELMI002479; ELM sequence: LPPLE; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)