HsaEX0002067 @ hg19
Exon Skipping
Gene
ENSG00000123983 | ACSL3
Description
acyl-CoA synthetase long-chain family member 3 [Source:HGNC Symbol;Acc:3570]
Coordinates
chr2:223781037-223783920:+
Coord C1 exon
chr2:223781037-223781214
Coord A exon
chr2:223782764-223782873
Coord C2 exon
chr2:223783782-223783920
Length
110 bp
Sequences
Splice sites
3' ss Seq
GCTGCTGCTTTTCCTTTTAGTTG
3' ss Score
8.55
5' ss Seq
AAGGTGAGG
5' ss Score
9.16
Exon sequences
Seq C1 exon
GTTATTCTTGGACAGTATAATTGGCTTTCCTATGAAGATGTCTTTGTTCGAGCCTTTAATTTTGGAAATGGATTACAGATGTTGGGTCAGAAACCAAAGACCAACATCGCCATCTTCTGTGAGACCAGGGCCGAGTGGATGATAGCTGCACAGGCGTGTTTTATGTATAATTTTCAGC
Seq A exon
TTGTTACATTATATGCCACTCTAGGAGGTCCAGCCATTGTTCATGCATTAAATGAAACAGAGGTGACCAACATCATTACTAGTAAAGAACTCTTACAAACAAAGTTGAAG
Seq C2 exon
GATATAGTTTCTTTGGTCCCACGCCTGCGGCACATCATCACTGTTGATGGAAAGCCACCGACCTGGTCCGAGTTCCCCAAGGGCATCATTGTGCATACCATGGCTGCAGTGGAGGCCCTGGGAGCCAAGGCCAGCATGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000123983-'10-12,'10-11,11-12
Average complexity
S*
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.021
Domain overlap (PFAM):
C1:
PF0050123=AMP-binding=PU(23.4=97.1)
A:
PF0050123=AMP-binding=FE(25.5=100)
C2:
PF0050123=AMP-binding=FE(32.6=100)
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGAAGATGTCTTTGTTCGAGCCT
R:
TGCAGCCATGGTATGCACAAT
Band lengths:
254-364
Functional annotations
There are 1 annotated functions for this event
PMID: 20429931
This event
[Inferred from paralogous MUTEX event in ASCL6]. Isoforms with different fatty acid Gate-domain motifs (by inclusion of mutually exclusive exons) have different activity and the form lacking this domain, isoform 3 (including no exon), showed no detectable activity.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)