HsaEX0052689 @ hg38
Exon Skipping
Gene
ENSG00000102317 | RBM3
Description
RNA binding motif (RNP1, RRM) protein 3 [Source:HGNC Symbol;Acc:HGNC:9900]
Coordinates
chrX:48575561-48576419:+
Coord C1 exon
chrX:48575561-48575630
Coord A exon
chrX:48575815-48576083
Coord C2 exon
chrX:48576314-48576419
Length
269 bp
Sequences
Splice sites
3' ss Seq
ATGACTGCCTTTTGTTCTAGGGG
3' ss Score
10.49
5' ss Seq
GATGTAAGT
5' ss Score
9.11
Exon sequences
Seq C1 exon
TGGTCGTTGTCAAGGACCGGGAGACTCAGCGGTCCAGGGGTTTTGGTTTCATCACCTTCACCAACCCAGA
Seq A exon
GGGGTGGAGGGCAGCGGCAGACAGAGCCTGGCCGCCTGGGAGGCGACGACTGGTCCTGCATGAGGCCGAGAAGCCACCTGTGGATGGTTGACCTGCCTTGGGCTTAGGTAGTAGAGTCTGCAGACCTGTGGGCCTGGCCCGGAGAGGACCTCGTGAGTCTTCTGACATGGACTCTGAAGCCTCAAACCAAGAGAGGTGTCTGTCTAGCCCTGATAGTCGGGCAGCTTAGAGGAGTGGGGAGGAGAACTCAGCCTGAGTTCAGTCAAGAT
Seq C2 exon
TCTCTGGATGGTCGTCAGATCCGTGTGGATCATGCAGGCAAGTCTGCTCGGGGAACCAGAGGAGGTGGCTTTGGGGCCCATGGGCGTGGTCGCAGCTACTCTAGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000102317_MULTIEX1-2/2=1-C2
Average complexity
S*
Mappability confidence:
100%=100=100%
Protein Impact
5' UTR
No structure available
Features
Disorder rate (Iupred):
C1=0.389 A=NA C2=0.714
Domain overlap (PFAM):
C1:
PF0007617=RRM_1=FE(49.3=100)
A:
NA
C2:
PF0007617=RRM_1=PD(9.9=19.4)
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Mouse
(mm9)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TCGTTGTCAAGGACCGGGAG
R:
TCTAGAGTAGCTGCGACCACG
Band lengths:
172-441
Functional annotations
There are 1 annotated functions for this event
PMID: 31911676
[CRISPR screen]. Conserved poison exon with pro-oncogenic impact when depleted: HeLa No Change at 14 days (FC=0.817, FDR=0.004), PC9 No Change at 14 days (FC=0.874, FDR=0.114), Late Xenograft Enriched (FC=1.769, FDR=0.000).
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- The Cancer Genome Atlas (TCGA)
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development