HsaEX0073615 @ hg19
Exon Skipping
Gene
ENSG00000170954 | ZNF415
Description
zinc finger protein 415 [Source:HGNC Symbol;Acc:20636]
Coordinates
chr19:53611133-53619686:-
Coord C1 exon
chr19:53619566-53619686
Coord A exon
chr19:53618957-53619177
Coord C2 exon
chr19:53611133-53613161
Length
221 bp
Sequences
Splice sites
3' ss Seq
TTTGTGAAATATTTTCCTAGATC
3' ss Score
6.12
5' ss Seq
CAGGTAAGA
5' ss Score
10.77
Exon sequences
Seq C1 exon
TTGACATTCAGGGACGTGGCCATCGAATTCTCTCAAGATGAGTGGAAATGCCTGAACTCTACACAGAGGACTTTATACAGGGATGTGATGTTGGAGAACTACAGGAACCTGGTCTCCCTGG
Seq A exon
ATCCATCTGTGATAGCCTCTCTTCTTATCCAAGCAAAGGGCTGAGATTCTTGAAAAGCCACAGCACATCATGTTCCATTCATTTTATAAGCGGGAAATTCTCTTCCTGACCAGAGTATTATCCTATGTGGGAGCACAGGAAAGAGCCCTGGACCATAGAAAGCCAAGTACGAGTAGCAAGAAAACCAAAAGGGTGGGAATGGATCAAAGGTGTGAAAACAG
Seq C2 exon
ATCTGTCTCGTAACTGTGTAATCAAGGAACTAGCACCACAACAGGAAGGTAACCCAGGAGAAGTATTCCACACAGTGACATTGGAACAACATGAAAAACATGACATTGAAGAGTTTTGCTTCAGGGAAATCAAGAAAAAAATACACGACTTTGACTGTCAGTGGAGAGATGATGAAAGAAATTGCAACAAAGTGACTACGGCCCCAAAAGAAAATCTTACTTGTAGGAGAGACCAACGCGATAGAAGAGGTATAGGAAACAAGTCTATTAAACATCAGCTTGGATTAAGCTTTCTACCACATCCCCATGAACTGCAGCAGTTTCAAGCTGAAGGGAAAATTTATGAATGTAACCATGTTGAGAAGTCTGTCAACCATGGTTCCTCAGTTTCACCACCCCAAATAATTTCTTCTACCATCAAAACCCATGTTTCTAATAAATATGGGACTGATTTCATCTGTTCTTCATTACTCACACAAGAACAGAAATCATGCATTAGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000170954_MULTIEX1-4/5=3-C2
Average complexity
C2*
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref, Alt. ATG)
Show structural model
Features
Disorder rate (Iupred):
C1=0.013 A=0.202 C2=0.108
Domain overlap (PFAM):
C1:
PF0135222=KRAB=WD(100=100.0)
A:
PF0135222=KRAB=PD(0.1=0.0)
C2:
PF134651=zf-H2C2_2=WD(100=5.3),PF134651=zf-H2C2_2=WD(100=5.1),PF0013017=C1_1=WD(100=12.5),PF134651=zf-H2C2_2=WD(100=4.9),PF134651=zf-H2C2_2=WD(100=4.9),PF134651=zf-H2C2_2=WD(100=5.1),PF134651=zf-H2C2_2=WD(100=5.1),PF134651=zf-H2C2_2=WD(100=5.1),PF0013017=C1_1=WD(100=10.6),PF134651=zf-H2C2_2=WD(100=5.1),PF134651=zf-H2C2_2=WD(100=5.1),PF134651=zf-H2C2_2=WD(100=5.1),PF0013017=C1_1=WD(100=11.7),PF134651=zf-H2C2_2=WD(100=5.1)
Other Inclusion Isoforms:
Associated events
Conservation
Chicken
(galGal3)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGAGTGGAAATGCCTGAACTCT
R:
TCTTTTGGGGCCGTAGTCACT
Band lengths:
294-515
Functional annotations
There are 1 annotated functions for this event
PMID: 17055453
This event
Isoforms 2-5 are cytoplasmic, isoform 1 is nuclear. Isoforms 2-5, but not 1, inhibit AP-1 and p53. Isoforms are all expressed in both adult and fetal tissue. Exon 3 = HsaEX0073614, Exon 4 = HsaEX0073615, ALTA in Exon 4 = HsaALTA0009817, Exon 5 = HsaEX0073616. Isoform 1: skips exons 3, 4 and 5; Isoform 2: skips exon 4; Isoform 3: short version of exon 4; Isoform 4: long form of exon 4 and skipping of exon 5; Isoform 5: skippin of exons 4 and 5.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)