HsaEX6018071 @ hg19
Exon Skipping
Gene
ENSG00000178385 | PLEKHM3
Description
pleckstrin homology domain containing, family M, member 3 [Source:HGNC Symbol;Acc:34006]
Coordinates
chr2:208841375-208890284:-
Coord C1 exon
chr2:208890113-208890284
Coord A exon
chr2:208865754-208866681
Coord C2 exon
chr2:208841375-208842310
Length
928 bp
Sequences
Splice sites
3' ss Seq
TCCTGTTTATTTTCTTCCAGGAA
3' ss Score
10.95
5' ss Seq
CTGGTATGT
5' ss Score
8.14
Exon sequences
Seq C1 exon
AGCATTTCAGAGTGGGACCGCGAGAAGCCGCTTGTAAACAGAGCCGGGCCGGGATGGTCAGCGCCCGGGCGGGCTGTCACCGTGAGGCGGGCGGCAGGCTGCGGGAGTCAAGCCCCTCCAGGAGCGGACTGAAGGCCCCGCAGGTGAATGGAGAGTAGCAGCCGGGGCCCAG
Seq A exon
GAAATCAAGGATTGGCGTGGCATTGCTTTGACAAGTACTTGCTGTTGTCTTCACAGAGGTCTCACTGAAGAATAATCTCAAAGGAACATTTGGTCTCCCTATACATCTGTTAATGCCCATTAGCCACTAGCAAATGCTTTTAATTACCAGGAAAACATCAACCACTTTGGGTTTGGCCTGCTCCAGGGAGCCCAATGAAGGTTTCTTCCAGTTGTTTCCATAGCTCTATTGCTGAAGCACCCCTCTTGGTTGGGTGAATGTTCATGAAGCCATTTCTGGAACCAGCTTAGGAGGCTAAGGCCTCCTGGAGCCTGTGACATGGAAGCTTTGGAAGTGGATGATATCAGCCCAGCCTTAGAAGTTACGGAGGAATTCTTTAGTACTTTGGATAGTAATCTAGAAAAGGCTGTGCAGCAGGCAGAGGTTTATGGGATCCAGGAAGTCCCTGAACTGGTGGGGCATGAGGTACTCAGTAACATAACAGACAATGGTGCTATGAGAAATGTCACCTCCCTGGGCAAGGGGGGCATGATTTGGGACCACTGTAAGAGCAGGCTCTTAGAAACCAAAGCTCAAAATGTCTTCCCTGCCAAAGAACAGTTTATGGTCCAGAGAGGGACAACCCCAGATAATCTTTCCTGGATGGAACAAAAGGAAGCATCAACCTTTAATTTCTTCAATATCTGTCAGCGTCGGAGGGACCGGCCTCGTTCTGTAAATGACTTACTGGATGAGACCTCAACTTTCAAGCCAGGGCATGCTCGATCACGATCAGATATTACCCAAGTGGACTGGAGGGTAGTCCTCAAAACCACGCCTTTGCAGCAGCAGCAACAGCAGCAGCCATTGCTTCAAGGCCCGCATGTCACCAGGCCATCTTTTCTGTTGCCCTCACCAAATAAGATAGAAGATGCTCAAGGAAATACTG
Seq C2 exon
AACACAAGCAGACATTCCCAAACATTCTAAAGAAGGGTTACCTGGAGATTAGAAAGGACCATGACAGTTACTGGCAAAGCTGTTATGCAGAACTTTCACCTTACAACTTATACTTCTACAGCCTCGACAGCAGTGGGAATCAAAACCTTTATGCCACGTACCAGCTTTCACACTTCCAGAGCATATCTGTTTTAGGCAACCTGGAGGCCAGGATGGTGGATACTGTTTTGTATGACAACACTCAGCTACAGCTAAAGGCAGAGTCACCATGGGAGGCTTTGGACTGGGGACAGAAGCTTTGGGAAGTAGTGCATGCTGCTGTGCCCGGTTACATGGGGCGGCAGAATGAGCTGACAATCTCACCAGGGCTTGGCCATCATGATGACTATACACAGAATCATAGTTTCCAGAAGAAAACCAGTGGGCTGCTGCCACCGTCCCCTGTCCTGGACAGCTCCAAACAGTACCAAAACATCCTCAAATCAGGGACTCTCTACAGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000178385-'0-2,'0-0,1-2=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion (Ref, Alt. ATG (<=10 exons))
No structure available
Features
Disorder rate (Iupred):
C1=NA A=0.328 C2=0.074
Domain overlap (PFAM):
C1:
NA
A:
NO
C2:
PF0016924=PH=WD(100=31.0),PF0016924=PH=WD(100=30.4)
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GTGAATGGAGAGTAGCAGCCG
R:
GCAGCATGCACTACTTCCCAA
Band lengths:
348-1276
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)