HsaINT0107506 @ hg19
Intron Retention
Gene
ENSG00000133392 | MYH11
Description
myosin, heavy chain 11, smooth muscle [Source:HGNC Symbol;Acc:7569]
Coordinates
chr16:15841904-15844188:-
Coord C1 exon
chr16:15843995-15844188
Coord A exon
chr16:15842026-15843994
Coord C2 exon
chr16:15841904-15842025
Length
1969 bp
Sequences
Splice sites
5' ss Seq
AGGGTGAGG
5' ss Score
7.13
3' ss Seq
GCCCTCTTTGACCTTTGCAGTCC
3' ss Score
8.84
Exon sequences
Seq C1 exon
TGGACCGCATCGTGGGCCTGGACCAGATGGCCAAGATGACGGAGAGCTCGCTGCCCAGCGCCTCCAAGACCAAGAAGGGCATGTTCCGCACAGTGGGGCAGCTGTACAAGGAGCAGCTGGGCAAGCTGATGACCACGCTACGCAACACCACGCCCAACTTCGTGCGCTGCATCATCCCCAACCACGAGAAGAGG
Seq A exon
GTGAGGCCCGCCGCCCAGACCCTGGGGCTCCCAGAAGCCAGGGCTGTCCCAAGCGGTCACAGCGTCCCCAGGGCGCCCTCTGCCCCCACCTACCCCGAGGACCCCATTTTCCATGTGGGGAAGGCTATCTGAATCTCAGACCCATTCCCCATCCCTGGAGGAAAAGGAGGAAGGGAGGATGCATCCAGAGACTTTTCAGTTGTGGAGTTGCTGTGCAGGTCATCCAGCCACTCATTCATTCATTATCCCAGGAAGTATTCACTGGGCTCTGCCCTGTCCTGGGTGCTGGGGAGCAGTGTTAGAAAAATTGTAGCCCTTCCCTGTGGGTTTCTCATAATCTGGTGCAGGCATCTTCAGCTTGGGGCGATTGTGTCCTCTATATGGACATGCTACAGACATTTTTGGTTGTCACAACCAGGAGGGGGCTGTTAGTCAGCATCTAGTGGGTAGGGGCCAGGGATGCCCTAAGCATTGTACAATGCACAGGATGGTCCCTCAACCCCCAGCACAGAATCCCTACAAGATGCCAGTAGTGCTGAGGTTATGGGAGACACGGGGAGAGGTAAACATACAGCTGATGATGGTGATGGAATGTGGTCAGTTAGGAGAACACCAAAGAGCCAGGGCTCCTCCCACAGCCTCAGGACTCAGAGAAAGCTTCTGGTGAACTTGAACGTTAAGAATGTGTGGCCATCAACTTGGTGACATGGAAGGCAGGGTGGGGCCTAGGATAAGCAGGGGGCCTAGGATAAGCAGAGGGCCCAGGCTAAGCAAGAGTGTGGAGGTGAGAAGTGAAGGAACTAGGTAAGAAAATGCTAGATAGTGTCCAGGCGTGTTGCTCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGAAACAAAAATCTGTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATTGCACCACAGCATTCCAGCCTGGGCAGCAGAGCGAGACTCCATCTTAAAAAAAAAAAAAAAAAAGGAAAGAAAATGCTAAATAGGTCATTTCATGTTGCAAATGTGTGATGGCATGAGGTAGGAATCAGATGGTGTGAGGTAGGATTGAGGCTGAATGGGTAGGCAGGGGCTAGATCGTGGTGCTCCTTGTGTTCTTTCTGGAGCTTGGCCTTCTCTCTCTAGGCATGCCATTGGGGGTGTTAAAGCAGGGCTATATCATGGTCAGATTTACATTTTAGGAAGTGAATGAGGGGGCTGGGCATATGCTAGCTCATGCCTATAATCCCAACACTTTGGGAGGTTGAGGTGGGAGGATCACTTGAGACCAGGTGTTCAAGGCTAGCCTGGGCAACATAGCAAGACCCTATATCTACAAAAACATTTTTAAAAATTTTCCAGGCATGGTAGCACATACCTGTGGTCCCAAATACTTGGGAGGCTGATTTGGGAGGATCACTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCCATGATCGCACCACTGGACTCCAGCCTGGCTGACAGAATGGGACCCTATCTCAAAAAATAAAAAGGACAAAGGGATTGAGGGGAGAGGCAAGACCAGAGAGAGAGACCAGGTGGGTGGTTTCTGTGGTTGTCCAGGCAGGAGAAGATAGTGGAGACAATGGTGGTGAAGAGAAGTGGGGGGGTTGGGAGATATTTGGGAGCTAGAAGCAATCAAACTGCTGATGGACAGGAAGTGAGGGAGACGAGGTGATGAGGAGGAAGCCCCAGGTTCCAGCCAGGCGATGCTAGTGTCACCAAGAACCAGAGAGATCATGAGGCAGCCATTGCCGAAGCAAAGAGATGAAAACCCAGAGGGGGGCACTGCTTTGCCCCTCGGCCCTCAGCTAAGCCCTCCTTGGGTGCTTCTGTTGGTACCCTCATGGCCTGGCCAGGTGGGTCATCCAGGTAGGAGGTTTGGGGCTTTGCTGCGCCATGGTTTCTGGCCCCAGGGATCCACTGCCCTCTTTGACCTTTGCAG
Seq C2 exon
TCCGGCAAGCTGGATGCGTTCCTGGTGCTGGAGCAGCTGCGGTGCAATGGGGTGCTGGAAGGCATTCGCATCTGCCGGCAGGGCTTCCCCAACCGGATCGTCTTCCAGGAGTTCCGCCAACG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000133392-MYH11:NM_001040113:17
Average complexity
IR-C
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.046 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0006316=Myosin_head=FE(9.3=100)
A:
NA
C2:
PF0006316=Myosin_head=FE(5.8=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGGGCCTGGACCAGATGG
R:
GTTGGCGGAACTCCTGGAAG
Band lengths:
303-2272
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)