HsaINT0122124 @ hg19
Intron Retention
Gene
ENSG00000138735 | PDE5A
Description
phosphodiesterase 5A, cGMP-specific [Source:HGNC Symbol;Acc:8784]
Coordinates
chr4:120442090-120446850:-
Coord C1 exon
chr4:120446704-120446850
Coord A exon
chr4:120442216-120446703
Coord C2 exon
chr4:120442090-120442215
Length
4488 bp
Sequences
Splice sites
5' ss Seq
GAGGTAGGA
5' ss Score
8.24
3' ss Seq
TTATGTTTTATTCCCTAAAGGTT
3' ss Score
8.23
Exon sequences
Seq C1 exon
GCTGCTGTGGTGCCATCTGCCCAGACCCTTAAAATTACTGACTTTAGCTTCAGTGACTTTGAGCTGTCTGATCTGGAAACAGCACTGTGTACAATTCGGATGTTTACTGACCTCAACCTTGTGCAGAACTTCCAGATGAAACATGAG
Seq A exon
GTAGGAATGCAGCAACATCCTTTGGAAAAGTCTATGTGTATGTGTGTGTGTATGTAAGAGAGAGAATTGGTTTTGAATGCAAATATGGAATAGGGATTTTTACATTTTAGTGATTAATATACTGTCACCTAATATATACCCGAGACTTTTAAAGAAAAATTATCATTATCAAAAAGACATTTAATGGGCTCCTAGCATGTATCAAGTATCAGGGTGAAGACTAAGGGAGAGTGTTCCTAAAAATAGGAGCAGGATGTTCAAAGGCATGACAGCAGAGATTGGGGGTGAGGGCCAGGAGTACTGTTGAGGGGTAAGAATGGCAAGAGAAGCAATGGAAGAAGGTGAGAAGCAAATGATACGGAACCTTGTAAGCCGTACAGATGAATTTGGATTTTACCCTGAAAACAATGGTGAGTCACAGGAATTTTATGCAGAGAAGTAGCATGATCTCACTGCAATGGTTATAACAATAGTGTACAGGGAAGGACCGAAGCAGAGTGAACTCCTTTGAAAATGAAGGAGGAAATAAAGGGGCCTGATGGGAGGCCAAGCTTTTAGTTGGAACAGGGTCACCCATATGGGTGAAGATGAAAACTGATTTTAACCTCTGTTGCTTACCTTATTCACTTCTCAGAAAATAGAAAAACTTAAATATCTTCTAATATCAGTTTGGAGATACTAGGGAATTCCGTTGTTTCATAATGGCTATGTATTATAATATATAGCATCAAAGAATAAGAAGCAGCAGAAAGGACTATTTAAAAAAAAGAATTCAGTAATCTTGCCTTTAAAAATTACTTTTTCTGATCAGTTGAATGTCTAGTCTCCTTGTACAGATTTCCTATCTGAAAATTTAAATATCTTGAAGGCCTCCACTATTTAGCATTGTATTAATTCAGGACTCTGCCAGGGGCACATTTCAGCGATGAGTTGTCCCTGCTCTCAAAGGCTTCACAGAAATGAAAACTAAGAGTGAATATAGCTAAGATTAATACATTGTCATTTATGGTATTATTGGAGGCCCAAATCTGGTTCTTCCTGAATTTAACCAAAGTTTATGTTACTCTTTCTTAGGTGAAAATAAAGAACAATTGTCCATAGACTCTTACCTAATAATACTTTACTCTTGTTAGAGTGCGTTGATTAAGGGATATCATGCCATTTAATTATTTCAACAAGTTCTCTAGAAAGGCTGTTACTGGGATTACTGTTATCCCCATTTTACAAATGAAGAAATTGGGACAGCATGGTAGAGTAGAAAGATCATGGATTTTTGAGTCATACCTCTGCTACTGGTTAGCTCTTTTTTCGTTGGGCAATTAATCACTCATATTCTCAGTTTCCTTTTCTGTTATTAGGGGTAATGGTATTATTCTCCCCATGGGAGTCTTACGAGAATTATACGTGCATCTGTGATTATCTATTTGTATGCATGTGTATGTATGTACTTATCTATAATATTCTGTTTAACAAACAGGTGTAGAGTCCATGTCAGTTATCCCATTCTTAGGCCAAGTTTGACTGGTTACATCACTCATCAAATTTCTCAATAGTAGGTCATAAGGCTCTTTTTTTAAAGCCGTATCTATTGATGAGATGAAGATCTCATTTGGAGCCAGAAGTTCTATGTGAATCTCACTTCTGCTTCTTGCTAGTTACAGGACTTTATAAACCTATATAGTATCTCAAATCCTTTTCCATTCCTGAGTACTCCCATTCTTGAAACTAATAATGATTCTGTTGAAAGGACTTGGCTAGAGTAGAGGAATGTGATTCTTGTACTTTTAAATGAAATTCATATAAGTTGATTTATTTCTCTTTGGCCTTTAGATAGCATTTGAGGGTTAGGTAATGAAGATAATCACTCAAAGTTTCTGTAGAAATCTTTATTCTTACCAGTTGTTGGGTTTTTATCCATGAGGAAAATATTTCCTCTTAATGTCTGATTCATCATCCTACCTTTTCTGGTTGAATAACTATTATTCTAATTCTGGCCAACATCAAACTTGAACATTGCCATCATTCTGGCTGGCCTTCCTTCCTTAGTGCCTCTTCTGTTTTGTTTCTTTCAGATATTATTGTCAGTATAATTTTAGGATGATGAAATAAAAATGTTAATGCTAGAGAGGATGTTAACATCATGAAGCTGTTGTGACTAAGAATATTTCATATTGAAAGATCTTCATGTTCTCTGCATGGCTTCTAAATCTTTAGTTATTCTCCTATAATGACTGTAACCATTGCCTCTTGCTGATCTCTGAAACAGATTCTTCATTCTGCTCAAGCCAATCTGCATGTGCTGTGCTTATTTTCACTTTTTATCTTTTACATCTCATTCCTCCCTGAATAATGTCTGTTCCACTCTCTACCACAACAAACATTTCTCTTCTTCAGAGCCTGACTTAAGAATATCTGTTTGTAAGAGAACCCTAGGCTTGACTTCATGCTGCTTCAATTGCTATTTGGCAATGTATAAACTTGCTCTCAATTTTATGTTTATTTACTTATTTCCTTTATATATGCAATTTTGTTATTTTTCACTACTGATTGAGTTTCTTGAAGCAGGAGCTAAGCTGTTTTCTGTTTCTTCTTTTTCTCCGGTGGCATCTTGAGTTCACCACTCAGGAAACCTTCCATAATTGTTAGAGACTGATTCAACGTATTGAACATGCTCTGTAGAGTCATCCAAACTGCAAATAAGTACTCAGTAGTCCTGTACAAAATACTGTCTTACAAATTTTAATGGTGTCCAGCATATCCACTGAGAACTTACCAGATATGACCATAATTTTCTTGTATGCTGTTGAGAACATCCTGGTAACAGAATCTAAAACTGTACTTAAATATAGGTACTAACTACTTTGTCCATTGGGTTATCCAATTCTATTAGGTCCGTCTTAATAAAAGGAAAATAGAGTAGTCCATTAGGAATTATGTTTCATAGAGTCATTTTGGTCATTGTTTCACAATATATGGTATTATATATTTAATTATATCTGTACATTTATGATTAGTAAAAAGATATATCCAAAGTTTAAATTTCTGGGTTTTCCTGTTTTTTTTCTTGCTGCTTTAATTAATCACCAGTAATTTTCTGCAACATATTTTCTAAACATATCAAAGAGAGTTTATAGATCTTACTTAAAAGTCTCTCAGTAAGATTAGTCTCCCAGTAAGATTCATCCATCACCTTCCTGACAGACTCTATTCAGATATGAAAAAATGGTGTAAGAAGCTGCAGTATGCTTGGGGTGAACACATTCAATCTTAGGCACACAGAAATCCTCCGCTTGGAATATGGCAACTCAGTGGGTAAAAAGGTTAGGAGACATTAGTGTTCTTTGTTATCAGAATTTCCTGTAAACTGAGCAATAGAACAGGAATAAAATGACCTGAAAAGGGAGGATATGGAAGCATTGATTTCCCACCAAGTTCTTTATAAGCAGTTTCTACCGACAATGAAGAAACCTTGTTTTTGGCCTACTTCTGTAGCTAATCGTATTGTGTTGAATATTGTCAAAGCAACATTCTTTTCCCTGGTACTTTTTCCATTTCCCAGGGCAATGTTCTTTGTGTTTGAAGCAACTCCAGTGATACATGTAGGGAGAATCACATATTTATTTTACAAATCCCCAAAAGTATAGTAAATCACTCAGATTTGAAGAGAGGCAGATTCTGATGCTAACACAGACCATGTTTAGGGCCCATGAGTCTCTGGGGATTTTATTTAATACACCACTTAGAAGTTGAATTAAACCCAACTCTTGAGACTTGCTGAAGTCTATCCTGCCCCCGGCCATCTTTTAAAGTGTTTTTTATATGGACCCCAGGGCTTTATTTGGCACATTTTTTTTTTAATTACTTCTTTGTAACCAGGCAGTAACTACCTGAATAAGTATAATTTAAAAGGACAAAGAGCTAATGACGGCATTGTCTTGTAGCTCCAATTTGTCCTCGGACATGTGCTATATACCTTGTTACTAGTCCACCCCCAGGGCCTTGCACTAAATACCTTCACGGATATACAACATGAGAGCATGGGAAGAACTTGGGAGTGGCCGCTTTTATGGCTCTCAAATGGTGAATTCATACCTATGTGAACCTTTGGACTCTCCTAGTTGGTGACACATGGAAATGGCACATGGACACATGGACCTTTTATTAAAAAAAAAAAAAACCTACCCAGTGCCCTACCCTGCCAAAAATACCCTTCTTAGGGATGTCTTGTGTTTTATATCAATTTAATTAGCATGGTACTTAACATGGTAGGCTGTGGAGTCAAATTGCTCAAGTTAGAATTTTGGCCCCATCCCTAACTAACAATATGACCTTCAGCAAGTTACCTCTCTGAGTGTCAGTTTTCTTGTCTGTAAGATGATCCAAATCGGAGTATCAGGCTAAATGTGAATGCTTTGTAGTGTCTGGAACATAGTAAATGTGTGAAGATGTTGGCAATTATTGTTACTACTTATGTTTTATTCCCTAAAG
Seq C2 exon
GTTCTTTGCAGATGGATTTTAAGTGTTAAGAAGAATTATCGGAAGAATGTTGCCTATCATAATTGGAGACATGCCTTTAATACAGCTCAGTGCATGTTTGCTGCTCTAAAAGCAGGCAAAATTCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000138735-PDE5A:NM_001083:12
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
PF0023314=PDEase_I=PU(9.6=54.8)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)