HsaINT0133049 @ hg19
Intron Retention
Gene
ENSG00000185198 | PRSSL1
Description
protease, serine, 57 [Source:HGNC Symbol;Acc:31397]
Coordinates
chr19:686925-692002:-
Coord C1 exon
chr19:691858-692002
Coord A exon
chr19:687189-691857
Coord C2 exon
chr19:686925-687188
Length
4669 bp
Sequences
Splice sites
5' ss Seq
CGGGTGAGC
5' ss Score
8.19
3' ss Seq
AACTCATGCTCTCCCTGCAGCTG
3' ss Score
10.62
Exon sequences
Seq C1 exon
AGACCTCCGCACTGGCCTGGTGGTGCTGGGCGCCCACGTCCTGAGTACTGCGGAGCCCACCCAGCAGGTGTTTGGCATCGATGCTCTCACCACACACCCCGACTACCACCCCATGACCCACGCCAACGACATCTGCCTGCTGCGG
Seq A exon
GTGAGCCCCGGGGGTGGATCTGACGTATGTTTAGTTTTTGAGACAGTCTCTCGCTCTGTCGCTCGGGCTGGAGGGCAATGGCGCAATCTCGGCTCACTGCAACCTCAGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCTCAAGTACATGGGATTACAGGTGCGCGCCACCAAGCCCATCTAATTTTTGTATTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAGCTCCTGACTTCAAATGATCCACCTGCCTCGGCCTCCCAAAGGGCTGGGATTACAAGCGTGAGCCACCGAGCCCGGCCTACTTTTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGTCAGAGTCTCGAACTGTCACGGGGGCTGGAGTGCAATGGCGCCATCTCGGCTCACTGTAACCTCCGCCTCCCAGGCTCAAGTGATTCTCCTGCCTCAGCCACCCAAGTAGCTGGGATTACAGGCACTCGCCACCAGACCTGGCTAGTTTTTTGTGTTTTTAGTAGAGATGGGGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCCAGTGATCCACCCACCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCATCGTGCCTGGCCATTTTTTTTTTCCAGGCTTAATTCACTTTATTTTTCGTGTATAAAACCCTATGTTGTAACCACAGCTGGAGCCGGGCGTCTGCACGGAGACTCTGGTGTGAGTCTTCACAAGATGGCCAGTGAATACCTGAAAGAGAGACTTGGGGAATACAGAGGTCAGGGGTCAGGCAGCTGTAGGTCTTAGAGAGGATATCAGAGGCGGCCTTGGCAAAGTGGCCCAGGGTGGCAGTGCAGCCCCTGGCTAAGGTGTAGCAGTCACCGATACCAGCCATCATGAGCAGCTTCTTGAGCACAGGCGCCCAGACGATGCCAGCGCCCCGGACACGGGGATCAGGCACACCAGCGCAGAGCCGCAGCGGCCTGTCACCTTGCCAGGGACGGTGTAGGGCTTGCCGATCTTGTTCCCCCAGTAGCCTCTGTGCATGGGGACAACGGAGAGCTTGGCCAGGATGACGGCCCCGATGATGGCAGTGGCTACCTCCTTGGAGCACTCAACACCCAGACCGACGTGGCCATTGTAGTCCCCGGTGGGAACAGACGCCTCGAACCTGGTGCGCTGGCCGGTGCGGATCTGCTTCTGCACCGGCATAATCTCCAAAACCTCGTCCTGGAGAGAGGCCCTCAGGAAAAGGTCAATGATCTCAGATTCCTTGATGGGCAGGGAGAAGAGACAGATCTCCTCCAGGGACATGATCTTTATGTCCTTGACCAGGCGGCCCAGCTTGGTGACAGGCGTCTACTCCTTATCCTCTGTCTTGCCTCTGTGAGCTCCGCGGCCCCAGCCCGGAAGCCAGTGCCGAAGCCTCGGGGGAAGCCAGCGCCGTTCCCCATCCCAGGGCCGCCCCACTGCACCGACGTCATCCGCCGTTTAGTGTTTTCCAGGAGAAGCAGCCCTGGGCTATTTTTTTTTTTTTCAGACAGTATCTCCCTGTGTCCCCAGGCTGGAGTGCAGTAGCACGATCTCGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCCCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTTGCCAGGATGGTCTCGATCTCTTGACCTCGTGATCCGCCCACCTCTGCCTCCCAATCCTGGCCTATTTTTTGAGACGGAGTCTCACTTTGGCACCTGGGCTGGAGTAAAGTGGCACAGTCAGGGCTCACTGCAACCTCCATCTCCCGGGTTCAAGCGATTCTCCTGCCTCGGCCTCCCGAGTAGCTGGGATCACAGGCACCCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGATTTCACCATGTTGGCCAGGCTGGTCTTAACTCCGGTCCTCAAGTGATCCGCCCACCTTGGTCTCCCAAAGTGTCGGGATCACGGGCGTGTACCACTGCGCCAGGCGAATTTTTATATTTTTAGTAGAGACGGGGTTTCACCATGTTGCCCAGGCTGGTCTTGACCTCCTGGACTCAGGCAATCCTCCTGCCTCAGCCCCGCAAAGTGCTGGGATTACAAACCTGAGCTGCTGCGCCTGGCCTGACTTAGGTTTTAAAGACAGTTGGACGTCAGGTCCCATTCCTCCTGTGCCCTGGACCCCCCAGTGGCTCCCACCTCCTGCAGGACAAATCCTCCTGGTGCCCACAGGCCCTGCTAATCCATGCCTGTCACCTTTCTGACTCGAGGCCAGCAGACCTCCCGGATGGGCCATCCCATCCCCAGCACAGTCTCCGCTCCGAGCTCTGCACCAGCTGTACCCAGTGCACCAGTTCCCCAGACACCGCGAGCCTTTCCCCTCACGCCTGTCAAGTCTTTGCTCAAATGTTACCTTCCCAGGAGGCCGCCCTGGACCACATACCCCCTCCCTGCAACCCTGTTCCAGCCCCGTCATCACCTGCTAACCCCTGGACCACCCTTCCGGCCCCGTCATCTCCTGCTAACCCCTGGACCACCCCGTCGTCACCTGCTAACCTGTGGACCACCCTTCCAGCCCCGTCGTCACCTGCTAACCCCTGGACCACCCTTCTAGCACCGTCGTCACCTGCTAACCCCTGGACCACCCTTCCGGCCCCGTCGTCACCTGCTTGTCACCTGCTAACCCCTGGACCACCCGCTTCCTCATTCCCGCTTCCTCTGAACCTAACGGGCAGGGATTTTTTATCACCTTTATGGCCATTTATGGCACACAGCAGGCGCTCAAAGTTTATGCTGAAATGGAATGAATGTGCCTCTCGGGCCCCTGCCCTGTGTGGAGGAGACGCTTAAAGTCCCTGTGTGGGGCCGGGCGTGGTGGCTCACACCTGTAACCCCAGCACTTTGGGAGGCCGAGGCGGGTAGATCATTTGAGGTCAGGAGTTTGAAACCAGACTGGCCAACGTGGTGAAACCCCATCTCTACTAAAAATAAAAAAATTAGCTGAGCCTGGTGGTGGGTGCCAGTCATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCCGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTGAAAAAAAAAAAAAAGTCCCTGGGTGGAGTCCTCCGGGTGGGAAGCTGCTCCTCCCACACGTGGTGCATCCATGCAGACCCGCCTGGCCCCCTCCTGCTCGAGGGACGACCCCTTCCCTGACGCTTCTACCCAGCATCCCAAAATTAAATTCCAGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCCGTGAGCCGAGATTGCGCCACTGCATTCCAGCCTGGACAACAGAGCAAGACTCTGAAAAAAACAAAAAAAAAAGGAGGAGGAGCAAGTGCCAGTAGCCAAAGCTTTTGGGTGAATTTTTCTCATCTGTGAAACCCTGAAGCCTGGAACCAGCGCTGGTTCACCCAGAGGCCATCGCACAGATGGGGAAACTGAGGCTGAGCGAGACATCAAGAATGTCAGGAATGAACCCAAGACGCACAAATCAGAGAACCAGAGACAGGGATTGGAGCCGTCCTTCCCAGGCCCATTAACTGAGCATCAGCTGTGTGCCAATTGCCAGGGCCAGGGCCAGAGGCCCGGTGCTGGGCCACACAGAGCCCGGGGTGTCACTCAGTCTTCACTGGGTAAACCGGCCTCAACAGGCTGCAGGGAGCCCAGAGAAGACTCACGTGCCAGCCTGGGAGTCTGGGAAGACTTCCTGGAAGAGGTGGCATCCATGCTGAGATGGCTGAATAGGAAAAGTGTTTCAGGCTGGGGGTCTGGTGTGAGGGGAGGTGTGTGGCAGGCCCAGGGAGTAGCTGTAAATTCATCCTGCCTGGCCAAAGGGGAGGCTGAGGCTGGAGAGCCCTCAGAGGCCCTGGCTGGTGAGCAAAGAGGTTTTGTCTTGAGGGCAATCGGGAGCCGTGGGAGGGCTTAGAGTAAGGAAGGAGATGGAGTTTGAAAGACTCTTTGAGGCTGGGCGCGGCGGCTCACTCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGAACAGCCTGGCCAACAGGGTGAAACCCCGTCTCTACTAAAATACCAAAATTAGCCAGGTGTGGTGGTGCACGCCTGTAATCCCAGCTGCTTGGGAGGCTGAGGCAGGAGAAATCGGTTGAACCTGGCAGGTGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCATCTCAAAAAAAAGAAAAGAACAGAACAGAAAGACCCTTTGGGCAGCTGACGGTGACCCTGGAGGCCTGAGGGGTAGGGGCCTGTGTTGGCAGAAGGAACGGGGCCTCCTGACCCGGCCTCATGGTGGCCGCCATTGATTTTGCTTCACAAGGGCAGGACCAGGGGTCCCATGGATAAACTGAGGCAGGAGCGGGGGTGGGGAGGGAGCCCAGTGGCCTGAACTCATGCTCTCCCTGCAG
Seq C2 exon
CTGAACGGCTCTGCTGTCCTGGGCCCTGCAGTGGGGCTGCTGAGGCCGCCAGGGAGAAGGGCCAGGCCCCCCACAGCGGGGACACGGTGCCGGGTGGCTGGCTGGGGCTTCGTGTCTGACTTTGAGGAGCTGCCGCCTGGACTGATGGAGGCCAAGGTCCGAGTGCTGGACCCGGACGTCTGCAACAGCTCCTGGAAGGGCCACCTGACACTTACCATGCTCTGCACCCGCAGTGGGGACAGCCACAGACGGGGCTTCTGCTCG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000185198-PRSSL1:NM_214710:3
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.091
Domain overlap (PFAM):
C1:
PF0008921=Trypsin=FE(21.3=100)
A:
NA
C2:
PF0008921=Trypsin=FE(38.7=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)