HsaINT0187291 @ hg19
Intron Retention
Gene
ENSG00000173275 | ZNF449
Description
zinc finger protein 449 [Source:HGNC Symbol;Acc:21039]
Coordinates
chrX:134480944-134483239:+
Coord C1 exon
chrX:134480944-134481397
Coord A exon
chrX:134481398-134483034
Coord C2 exon
chrX:134483035-134483239
Length
1637 bp
Sequences
Splice sites
5' ss Seq
CAGGTAAGA
5' ss Score
10.77
3' ss Seq
GGTTCTGGCATTTCCCCCAGGTT
3' ss Score
8.3
Exon sequences
Seq C1 exon
CTGTAGGTGGCTCCCTCCCACCCCAACGATTTCAGAGAGAAACAAGTCGGAATCTGAGAAGTGAGGCTCCAGATAAACTGTAAACTGCTGGAAGGGGGCGATGGCTGTGGCCCTGGGTTGTGCAATCCAGGCATCCTTGAATCAAGGCTCTGTGTTTCAAGAATATGATACTGACTGTGAAGTTTTCCGTCAGCGCTTCAGGCAGTTCCAGTACAGAGAAGCAGCTGGGCCTCATGAAGCATTTAACAAACTCTGGGAGCTTTGCTGTCAATGGCTGAAGCCAAAGATGCGCTCTAAGGAACAAATCCTGGAGCTGCTAGTGTTGGAGCAATTCCTAACTATCCTGCCCACAGAGATAGAGACCTGGGTGAGGGAGCACTGCCCAGAGAATAGAGAAAGAGTTGTGTCACTGATAGAAGACTTACAGAGAGAACTTGAGATACCAGAGCAGCAG
Seq A exon
GTAAGAAAAGAATGTGGGATCTTTGTGATTGGTCCAAAGGAAGTAGCTGAGGCAGCTGGGACTAGACCACACATTTGTCTCTATGTCATTCCCCAGCCTCAAGATTTCTCCAGAGTCCTCTTCCTTTTTCTCTTCTGCTGAACTCAGCAAATGAGTCAGTGCTTTTAACTCTATCAGACTCAATTCCCCTTCTATAACAAATAGTTTATAATGTCCACTTTACTATGCACAAATGAAATTGATAGACAACATAATCTACCCACATACATCAACCCAAAGCATCAGTAAATTGCTCCATGGCCTGAAGGCCAATTCTAGCCATACCCTGTTTATCTGTATACTCTGTATGTAATGGTTTTTTTATCTTGTTGAAAGGTCATTGAAAAAAAGAGGAAGGAGAAGAACTGACAGTGAATGTGCCCCACAGTGCCTAAAATATTTACTATTTGGCTCTTTATAAAGTTTGCCAACCCTGAATCAAGTCTAGAAGGAATATAAAGGAAAAGAAACATAGTTTGTTATAAATTGATAGGGATTTGTACATATATGTGCTTGGGCCTGACCGAATGTCATGAAGTTGTCAGATGTTTGCATCTATGCTTAGAATCATTGTGAATGGGACAGCCAGAAATTCAGACTGATAAAGCTCAAGTACTACGAACAGTGTTGCTCCTCGTCATGTGATTTTCCAAAATGGCATACGACTCTAGGTAAATCTGAACAATAAGCAGTGTAGTCTTTGCTTTTCACATTAGTGCATTCCTAGAAAATTTCATTTGTGCTGAAACTATGCAAAACAAAACAAACAATTGTACTTATTTGACCAACAAGGTGGGGTTCTTGACAGGTTCTTTTTACTCACATGAATGTTTGAGTGGGACATTCCACACTTGGTAGGGACCTAGAACAATTCTGCATTGTAAATTATGTTCCATTAAATTCTGATAGCCACCACCTGTCAGCATATCCAAAACTCCCCATGGGGACAGTGGCACTGTCTGCCATTCAGAATGACTGTGTAAAGCCTCTTTTCAGAAGTGCCGTGACTGAGAGAGGGCAGTATCTTTGGGAAAAGGGAGCAGGAGCTTCCAGATGGGCATCAGGGATACTCCAGTCTTGTCTATGGGGGTTCTCTGCAGGAGCTGTTAGCTTCAGGGCTCCTGAACAGGAGTCTTCTGAAGTTTTCTGTCTCCCTAGGGTACTTGGGTTGGTGGTTGCCCTTCCTTTCTCTGTCTCCTTGGTTTTGTTTACTATATAAGATTTTATCTTCATGTGGTCTAGACATTTGCTGCTGAATACAGTCACTACTAGTCATGTACAGCTCTTGAGCCCTTGAAATATGGCCAATACAAATTGAGATCTGCTGTAAGTATGAAATACACACCACATGCAGAAGACTTGGTATGAAAAAAGTAGGTGAAATATCTCACTAATAATTGTTCATATTGATTACATGTTGAAATCCTGATTGTTTGCACTGGATTAAGTAACACGTACTATTAAGATTGGCCTTACTTTTTAAAAAATTTATTCATATGGCCACTAGAAAATTTAAAATTACATGCATGATTCTCATACAATTCTACTGGGCACTGTTGGTCTAGACTTGAGAGTGATGGTTCTGGCATTTCCCCCAG
Seq C2 exon
GTTGATATGCATGACATGCTCTTGGAAGAACTGGCACCAGTGGGAACGGCACACATACCACCAACCATGCACCTAGAGTCACCTGCACTCCAGGTAATGGGACCTGCCCAGGAGGCCCCAGTAGCAGAGGCATGGATCCCACAGGCAGGGCCACCGGAGCTGAACTATGGTGCTACTGGAGAATGTCAGAACTTTCTGGACCCTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000173275-ZNF449:NM_152695:2
Average complexity
IR-C
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.432
Domain overlap (PFAM):
C1:
PF0202312=SCAN=PU(97.9=79.7),PF0143014=HSP33=WD(100=88.1)
A:
NA
C2:
PF0202312=SCAN=PD(0.1=0.0)
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AAGTTTTCCGTCAGCGCTTCA
R:
ATGGTTGGTGGTATGTGTGCC
Band lengths:
343-1980
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)