Special

MmuEX0003024 @ mm9

Exon Skipping

Gene
ENSMUSG00000041828 | Abca8a
Description
ATP-binding cassette, sub-family A (ABC1), member 8a [Source:MGI Symbol;Acc:MGI:2386846]
Coordinates
chr11:109939938-109944850:-
Coord C1 exon
chr11:109944624-109944850
Coord A exon
chr11:109940387-109940528
Coord C2 exon
chr11:109939938-109940123
Length
142 bp
Sequences
Splice sites
3' ss Seq
GAATTCTGTTTTTGTATCAGGCT
3' ss Score
6.88
5' ss Seq
CTGGTGAGT
5' ss Score
10.1
Exon sequences
Seq C1 exon
GTCACAACAAATCACTCAGTGATGGAAGAGATGATGTCACTTACCGGAAAATACATCAAGATAGATTCTTTCGTTGGGCAAGAAGGGACAACGACAGACTGCTTCCTTTTTTTCTGTATCATTCGTTTCTCCCCACTTACCTATTATATCTCAGCTGGTGTTACAAGAGAAAGGAAAAAGATGAAGGGCTTGATGGCAGTGATGGGCCTTCGGGATTCAGCATTCTG
Seq A exon
GCTGTCCTGGGGTTTGCTCTATGGTGTCATTGTCTTCGTTGTGACCCTTCTCTCGACAACTATTGTAAAACTGGTCCAATTTGTCTTTTTGACTGGATTTATGGTGATCTTCAGTCTCTTTTTCTTCTATGGCTTATCTCTG
Seq C2 exon
ATCTCTTTGTCTTTCTTGATGAGTGTTTTACTAAAGAAGTCTTTTCTCACTGACCTGGTGGTGTTCTTGCTCACTGTTTCCTGTGGAAGTCTTGGATTCACAGCATTGTACAGATACCTTCCTGTATCCTTGGAGTGGCTTCTAAGTTTGCTCAGTCCCTTTGCTTTTATGCTTGGAATGGTCCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000041828-'8-8,'8-7,9-8
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF126982=ABC2_membrane_3=FE(19.3=100)

							
A:
PF126982=ABC2_membrane_3=FE(12.1=100)

							
C2:
PF126982=ABC2_membrane_3=FE(15.7=100)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000097860





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000045808, ENSMUSP00000102275
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr17:68929561-68929702 
ALTERNATIVE
HsaEX6024391
(ABCA8)
Human
(hg19)
chr17:66925702-66925843 
HIGH PSI
HsaEX6024391
(ABCA8)
Rat
(rn6)
chr10:98286860-98287001 
HIGH PSI
RnoEX6050274
(Abca8)
Cow
(bosTau6)
chr19:62111026-62111167 
HIGH PSI
BtaEX6091180
(ABCA9)
Chicken
(galGal4)
chr18:8200205-8200343 
HIGH PSI
GgaEX1004161
([1])
Chicken
(galGal3)
chr18:7934899-7935037 
HIGH PSI
GgaEX1004161
([2])
Zebrafish
(danRer10)
chr12:38648590-38648731 
HIGH PSI
DreEX6070642
(abca5)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TCTTTCGTTGGGCAAGAAGGG

				
R: 
GGAAACAGTGAGCAAGAACACC

				
Band lengths: 
242-384

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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