Special

MmuEX0004899 @ mm9

Exon Skipping

Gene
ENSMUSG00000032826 | Ank2
Description
ankyrin 2, brain [Source:MGI Symbol;Acc:MGI:88025]
Coordinates
chr3:126665169-126668080:-
Coord C1 exon
chr3:126667856-126668080
Coord A exon
chr3:126666301-126666399
Coord C2 exon
chr3:126665169-126665323
Length
99 bp
Sequences
Splice sites
3' ss Seq
GCTGCTTTGGATGTACTCAGTAA
3' ss Score
2.33
5' ss Seq
TGGGTAGGA
5' ss Score
5.12
Exon sequences
Seq C1 exon
TTTCCTAGTCAGTTTTATGGTGGATGCCCGTGGTGGTGCCATGCGAGGATGCAGACACAATGGACTCAGAATCATTATCCCACCTCGGAAATGCACAGCCCCAACTCGCGTCACCTGCCGCCTTGTGAAACGCCATCGACTGGCAACAATGCCGCCCATGGTGGAAGGAGAAGGCCTGGCCAGCCGCCTGATTGAAGTCGGACCTTCGGGAGCTCAGTTTCTTGG
Seq A exon
TAAACTTCACCTGCCAACGGCTCCTCCCCCACTTAATGAGGGAGAAAGTTTGGTCAGCCGCATCCTTCAGCTGGGGCCTCCTGGAACCAAATTCCTTGG
Seq C2 exon
GCCCGTGATCGTGGAGATCCCTCACTTCGCCGCTCTTCGAGGAAAGGAGAGGGAGCTGGTGGTCCTGCGCAGTGAAAATGGGGACAGCTGGAAAGAGCATTTCTGCGACTACACTGAGGATGAATTGAACGAAATCCTTAATGGCATGGATGAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000032826_CASSETTE2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
Alternative protein isoforms (No Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.006 A=0.140 C2=0.019
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0079115=ZU5=FE(89.3=100),PF0079115=ZU5=PU(0.1=0.0)

							
A:
PF0079115=ZU5=PD(8.3=20.6),PF0079115=ZU5=PU(53.2=97.1)

							
C2:
PF0079115=ZU5=PD(26.7=52.8)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000126883f3048A





     
                   









    
Main Skipping Isoform:
ENSMUSP00000130908f3049A





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000126883, ENSMUSP00000126883f3045A, ENSMUSP00000126883f3047A
          









    
Other Skipping Isoforms:
ENSMUSP00000036378, ENSMUSP00000043765, ENSMUSP00000102003, ENSMUSP00000126802, ENSMUSP00000127248, ENSMUSP00000130908
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr4:113331972-113332070 
ALTERNATIVE
HsaEX0004132
(ANK2)
Human
(hg19)
chr4:114253128-114253226 
ALTERNATIVE
HsaEX0004132
(ANK2)
Rat
(rn6)
chr2:231268190-231268288 
ALTERNATIVE
RnoEX0009352
(Ank2)
Cow
(bosTau6)
chr6:13431647-13431745 
ALTERNATIVE
BtaEX0003407
(ANK2)
Chicken
(galGal4)
chr4:56374441-56374539 
ALTERNATIVE
GgaEX0018077
(chAnk2)
Chicken
(galGal3)
chr4:58329616-58329714 
ALTERNATIVE
GgaEX0018077
(Q90716_CHICK)
Zebrafish
(danRer10)
chr7:57636791-57636889 
ALTERNATIVE
DreEX0013090
(ank2b)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TATCCCACCTCGGAAATGCAC

				
R: 
CGAAGTGAGGGATCTCCACGA

				
Band lengths: 
179-278

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 1 annotated functions for this event 


PMID: 22749401
MmuEX0004899
Inclusion enhances interaction with EPB4L2, DCTN4, SCN1B, SLC8A1, DNAJB1, CDH1, ATP1A1, SPNA2. By LUMIER.


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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