Special

MmuEX0008200 @ mm9

Exon Skipping

Gene
ENSMUSG00000024335 | Brd2
Description
bromodomain containing 2 [Source:MGI Symbol;Acc:MGI:99495]
Coordinates
chr17:34253143-34254156:-
Coord C1 exon
chr17:34253853-34254156
Coord A exon
chr17:34253543-34253634
Coord C2 exon
chr17:34253143-34253280
Length
92 bp
Sequences
Splice sites
3' ss Seq
GCCCTGGCTCCATTTTACAGATT
3' ss Score
9.25
5' ss Seq
GAGGTAATG
5' ss Score
8.73
Exon sequences
Seq C1 exon
GCTCCCTGGGGAAGGGAATGCAGGGTTACTGGGGCTGGGCCCAGAGGCAGCAGCACCAGGGAAAAGGATTCGAAAGCCTTCTCTGCTGTATGAGGGATTTGAGAGCCCCACAATGGCTTCTGTACCAGCTTTACAACTGGCCCCTGCCAATCCACCACCCCCTGAGGTGTCCAATCCCAAAAAGCCAGGACGGGTAACAAACCAACTGCAGTACCTGCACAAGGTAGTGATGAAGGCTCTGTGGAAGCATCAGTTTGCATGGCCATTCCGGCAGCCTGTGGACGCTGTGAAGCTGGGTTTGCCG
Seq A exon
ATTCCCACCCCTGGTTGGGAGAGGACCACGGTGGCCAAAATTCTTAGCTTCTTCCTTTCCCTCATGCAGCCCATGGATAGCCATCCCCAGAG
Seq C2 exon
GATTATCACAAAATTATAAAACAGCCTATGGACATGGGTACTATCAAGAGGAGACTTGAAAACAATTACTACTGGGCTGCCTCAGAATGTATGCAGGATTTTAATACTATGTTTACCAACTGTTACATTTATAACAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000024335_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence inclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.387 A=0.000 C2=0.003
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0043920=Bromodomain=PU(31.8=26.5)

							
A:
NO

							
C2:
PF0043920=Bromodomain=PU(75.0=97.3)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000128835





     
                   









    
Main Skipping Isoform:
ENSMUSP00000025193





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
ENSMUSP00000025193f1531A, ENSMUSP00000092990, ENSMUSP00000109880, ENSMUSP00000117359
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr6:32975021-32975112 
ALTERNATIVE
HsaEX0008410
(BRD2)
Human
(hg19)
chr6:32942798-32942889 
ALTERNATIVE
HsaEX0008410
(BRD2)
Rat
(rn6)
chr20:5264706-5264797 
Cow
(bosTau6)
chr23:7242207-7242298 
ALTERNATIVE
BtaEX0005726
(BRD2)
Chicken
(galGal4)
chr16:90371-90467 
ALTERNATIVE
GgaEX1011182
(BRD2)
Chicken
(galGal3)
chr16:80541-80637 
ALTERNATIVE
GgaEX0000085
(BRD2)
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GATGAAGGCTCTGTGGAAGCA

				
R: 
TACATTCTGAGGCAGCCCAGT

				
Band lengths: 
167-259

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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