Special

MmuEX0012690 @ mm10

Exon Skipping

Gene
ENSMUSG00000022521 | Crebbp
Description
CREB binding protein [Source:MGI Symbol;Acc:MGI:1098280]
Coordinates
chr16:4154857-4188636:-
Coord C1 exon
chr16:4188536-4188636
Coord A exon
chr16:4179958-4180133
Coord C2 exon
chr16:4154857-4155033
Length
176 bp
Sequences
Splice sites
3' ss Seq
CATTTCTGCTTAATTTCTAGATT
3' ss Score
8.4
5' ss Seq
AATGTGAGT
5' ss Score
7.8
Exon sequences
Seq C1 exon
GGGAAGCAGAGATAAAAGACTTAGAGGTCAATCTGGTCTTCATAGTAAGTTCCAGGATATTGTGAGATCCTGTTTCAAGAAACAAACACCCAACCAATAAA
Seq A exon
ATTTTGGATCATTGTTTGACTTGGAAAATGACCTTCCTGATGAGCTGATCCCCAATGGAGAATTAAGCCTTTTAAACAGTGGGAACCTTGTTCCAGATGCTGCGTCCAAACATAAACAACTGTCAGAGCTTCTTAGAGGAGGCAGCGGCTCTAGCATCAACCCAGGGATAGGCAAT
Seq C2 exon
ATGGGAATGACTGGTACCACAAGTCCATTTGGACAACCCTTTAGTCAAACTGGAGGGCAGCAGATGGGAGCCACTGGAGTGAACCCCCAGTTAGCCAGCAAACAGAGCATGGTCAATAGTTTACCTGCTTTTCCTACAGATATCAAGAATACTTCAGTCACCACTGTGCCAAATATG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000022521-'3-2,'3-1,4-2
Average complexity
C3*
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=NA A=1.000 C2=0.956
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NA

							
A:
NO

							
C2:
PF152541=CCDC14=PU(38.6=83.1)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000023165





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000146330
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm9




Conservation


Human
(hg38)
chr16:3850297-3851009 
HIGH PSI
HsaEX0017193
(CREBBP)
Human
(hg19)
chr16:3900298-3901010 
HIGH PSI
HsaEX0017193
(CREBBP)
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
chr25:3143570-3144282 
HIGH PSI
BtaEX6108227
(CREBBP)
Chicken
(galGal4)
chr14:12562674-12563386 
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
chr22:26876421-26877043 
HIGH PSI
DreEX0024200
(crebbpa)
Zebrafish
(danRer10)
chr3:9738486-9739132 
HIGH PSI
DreEX0024221
(crebbpb)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
AGACTTAGAGGTCAATCTGGTCT

				
R: 
AGTGGTGACTGAAGTATTCTTGA

				
Band lengths: 
250-426

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 1 annotated functions for this event 


PMID: 9192902
HsaEX0017193
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: not specified, two hybrid. ELM ID: ELMI000789; ELM sequence: QLSELLR; Overlap: FULL


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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