Special

MmuEX0048177 @ mm9

Exon Skipping

Gene
ENSMUSG00000016942 | Tmprss6
Description
transmembrane serine protease 6 [Source:MGI Symbol;Acc:MGI:1919003]
Coordinates
chr15:78272712-78274642:-
Coord C1 exon
chr15:78274526-78274642
Coord A exon
chr15:78274107-78274275
Coord C2 exon
chr15:78272712-78272983
Length
169 bp
Sequences
Splice sites
3' ss Seq
TCCCCCCCCACCATTATCAGACT
3' ss Score
6.04
5' ss Seq
CAGGTGAGG
5' ss Score
10.07
Exon sequences
Seq C1 exon
GAGTGCCCTGTGGGACATTCACTTTCCAGTGTGAGGACCGGAGCTGTGTGAAGAAGCCCAACCCAGAGTGTGACGGCCAGTCAGATTGCAGAGACGGCTCAGATGAGCAACACTGTG
Seq A exon
ACTGTGGCCTCCAGGGCCTCTCCAGCCGTATTGTGGGCGGGACCGTGTCCTCCGAGGGTGAGTGGCCATGGCAGGCCAGCCTCCAGATTCGGGGTCGACACATCTGTGGGGGGGCTCTCATCGCTGACCGCTGGGTCATAACGGCCGCCCACTGCTTCCAGGAGGACAG
Seq C2 exon
CATGGCCTCCCCGAAGCTGTGGACCGTGTTCCTGGGAAAGATGCGGCAGAACTCGCGCTGGCCAGGCGAGGTGTCCTTCAAGGTGAGCCGTCTGTTCCTGCACCCGTACCACGAGGAGGACAGCCATGACTACGACGTGGCCCTGCTGCAGCTCGACCACCCCGTGGTGTACTCGGCCACTGTGCGCCCCGTCTGCCTGCCTGCCCGCTCCCACTTCTTTGAGCCAGGCCAGCACTGCTGGATCACAGGCTGGGGAGCCCAGCGAGAGGGTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000016942_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0005713=Ldl_recept_a=WD(100=95.0)

							
A:
PF0008921=Trypsin=PU(20.0=80.7)

							
C2:
PF0008921=Trypsin=FE(39.6=100)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000017086





     
                   









    
Main Skipping Isoform:
ENSMUSP00000131799





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr22:37070484-37070652 
HIGH PSI
HsaEX6026688
(TMPRSS6)
Human
(hg19)
chr22:37466524-37466692 
HIGH PSI
HsaEX6026688
(TMPRSS6)
Rat
(rn6)
chr7:119663253-119663421 
HIGH PSI
RnoEX6032984
(Tmprss6)
Cow
(bosTau6)
chr5:75874802-75874970 
HIGH PSI
BtaEX6023243
(TMPRSS6)
Chicken
(galGal4)
chr1:51332071-51332239 
HIGH PSI
GgaEX1059430
(TMPRSS6)
Chicken
(galGal3)
chr1:53459762-53459930 
HIGH PSI
GgaEX1059430
(F1NDU7_CHICK)
Zebrafish
(danRer10)
chr6:210460-210628 
HIGH PSI
DreEX0008916
(TMPRSS6)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TGCAGAGACGGCTCAGATGAG

				
R: 
CTGGCTCAAAGAAGTGGGAGC

				
Band lengths: 
258-427

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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