MmuEX6069912 @ mm9

Exon Skipping

Gene

ENSMUSG00000006932 | Ctnnb1

Description

catenin (cadherin associated protein), beta 1 [Source:MGI Symbol;Acc:MGI:88276]

Coordinates

chr9:120859291-120860265:+

Coord C1 exon

chr9:120859291-120859351

Coord A exon

chr9:120859640-120859867

Coord C2 exon

chr9:120860012-120860265

Length

228 bp

Sequences

Splice sites

3' ss Seq

AACATACTCTGTTTTTACAGCTG

3' ss Score

8.84

5' ss Seq

CTGGTAAAG

5' ss Score

5.75

Exon sequences

Seq C1 exon

GGTACCTGAAGCTCAGCGCACAGCTGCTGTGACACCGCTGCGTGGACAATGGCTACTCAAG

Seq A exon

CTGACCTGATGGAGTTGGACATGGCCATGGAGCCGGACAGAAAAGCTGCTGTCAGCCACTGGCAGCAGCAGTCTTACTTGGATTCTGGAATCCATTCTGGTGCCACCACCACAGCTCCTTCCCTGAGTGGCAAGGGCAACCCTGAGGAAGAAGATGTTGACACCTCCCAAGTCCTTTATGAATGGGAGCAAGGCTTTTCCCAGTCCTTCACGCAAGAGCAAGTAGCTG

Seq C2 exon

ATATTGACGGGCAGTATGCAATGACTAGGGCTCAGAGGGTCCGAGCTGCCATGTTCCCTGAGACGCTAGATGAGGGCATGCAGATCCCATCCACGCAGTTTGACGCTGCTCATCCCACTAATGTCCAGCGCTTGGCTGAACCATCACAGATGTTGAAACATGCAGTTGTCAATTTGATTAACTATCAGGATGACGCGGAACTTGCCACACGTGCAATTCCTGAGCTGACAAAACTGCTAAACGATGAGGACCAG

VastDB Features

Vast-tools module Information

Secondary ID

ENSMUSG00000006932-'6-11,'6-10,10-11=AN

Average complexity

A_S

Mappability confidence:

100%=100=100%

Protein Impact

Alternative protein isoforms (Ref)

No structure available

Features

Disorder rate (Iupred):

C1=0.300 A=0.710 C2=0.378

Domain overlap (PFAM):

C1:

PF100524=DUF2288=PU(9.8=80.0)

A:

NO

C2:

PF136461=HEAT_2=PU(46.1=55.3)

Main Inclusion Isoform:

ENSMUSP00000007130

Main Skipping Isoform:

NA

Other Inclusion Isoforms:

ENSMUSP00000116365, ENSMUSP00000116969, ENSMUSP00000120132, ENSMUSP00000125763, ENSMUSP00000126905

Other Skipping Isoforms:

NA

Associated events

Other assemblies

mm10

Conservation

Human

(hg38)

chr3:41224526-41224753

HIGH PSI

HsaEX7001962

(CTNNB1)

Human

(hg19)

chr3:41266017-41266244

Rat

(rn6)

chr8:129618172-129618399

HIGH PSI

RnoEX0025175

(Ctnnb1)

Cow

(bosTau6)

chr22:13876468-13876695

HIGH PSI

BtaEX6093584

(CTNNB1)

Chicken

(galGal4)

chr2:44040100-44040327

HIGH PSI

GgaEX6019680

(CTNNB1)

Chicken

(galGal3)

chr2:43472327-43472554

HIGH PSI

GgaEX6019680

(CTNNB1)

Zebrafish

(danRer10)

chr16:6297022-6297246

HIGH PSI

DreEX6039315

(ctnnb1)

Fruitfly

(dm6)

No conservation detected

Primers PCR

Suggestions for RT-PCR validation

F:

GTACCTGAAGCTCAGCGCAC

R:

AGCAGTTTTGTCAGCTCAGGA

Band lengths:

298-526

Functional annotations

(Submit an annotation)

There are 5 annotated functions for this event

PMID: 12417018

MmuEX6069912

Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: mutation analysis, western blot. ELM ID: ELMI002615; ELM sequence: YLDSGIHS; Overlap: FULL

PMID: 10074433

HsaEX7001962

Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: . ELM ID: ELMI002616; ELM sequence: YLDSGIHS; Overlap: FULL

PMID: 11955436

HsaEX7001962

Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: . ELM ID: ELMI002616; ELM sequence: YLDSGIHS; Overlap: FULL

PMID: 12820959

HsaEX7001962

Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: . ELM ID: ELMI001302; ELM sequence: DSGIHS; Overlap: FULL

PMID: 19061640

HsaEX7001962

Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: . ELM ID: ELMI002616; ELM sequence: YLDSGIHS; Overlap: FULL