Special

MmuEX6101919 @ mm9

Exon Skipping

Gene
ENSMUSG00000027070 | Lrp2
Description
low density lipoprotein receptor-related protein 2 [Source:MGI Symbol;Acc:MGI:95794]
Coordinates
chr2:69318073-69320440:-
Coord C1 exon
chr2:69320282-69320440
Coord A exon
chr2:69319182-69319471
Coord C2 exon
chr2:69318073-69318276
Length
290 bp
Sequences
Splice sites
3' ss Seq
TTTCTTTCTCTTTGCTTCAGGCA
3' ss Score
10.71
5' ss Seq
CAGGTAAGG
5' ss Score
11.08
Exon sequences
Seq C1 exon
GTACATGTATTGGACTGACTGGGGTACCAATGCCAAAATTGAAAGAGCCACACTGGGAGGGAACTTCCGGGTCCCCATTGTGAACACCAGCCTGGTTTGGCCCAATGGACTCACTCTGGACCTGGAGACCGACCTTCTCTACTGGGCGGATGCTAGCCT
Seq A exon
GCAGAAAATAGAGCGCAGTACTCTCACGGGCTCCAACCGAGAAGTTGTCATCAGCACTGCCTTCCATTCCTTTGGCTTAACTGTCTACGGCCAGTACATTTACTGGACAGACTTTTACACCAAAAAAATCTACCGTGCTAACAAGTACGATGGGTCAGACCTGATTGCAATGACCACTCGTTTGCCCACCCAGCCTAGTGGCATCTCCACAGTTGTCAAGACCCAGCAGCAGCAGTGTAGCAATCCTTGTGACCAGTTCAATGGAGGATGCAGCCATATCTGTGCTCCAG
Seq C2 exon
GTCCAAACGGAGCTGAGTGCCAGTGTCCACACGAAGGCAGCTGGTATCTGGCCAACGATAACAAGTACTGTGTGGTGGACACAGGTGCCCGCTGTAATCAGTTCCAGTTCACCTGCCTTAATGGGCGTTGTATCTCTCAGGATTGGAAATGTGACAATGACAACGACTGTGGTGATGGCAGTGATGAGCTGCCCACAGTCTGTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000027070-'48-46,'48-45,49-46=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.010 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0005812=Ldl_recept_b=WD(100=77.8),PF0005812=Ldl_recept_b=PU(23.1=16.7)

							
A:
PF0005812=Ldl_recept_b=PD(74.4=29.6),PF146701=FXa_inhibition=PU(36.8=14.3)

							
C2:
PF146701=FXa_inhibition=PD(60.5=33.3),PF0005713=Ldl_recept_a=WD(100=56.5)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000079752f6174A





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000079752, ENSMUSP00000079752f2045A
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr2:169203982-169204271 
ALTERNATIVE
HsaEX6016556
(LRP2)
Human
(hg19)
chr2:170060492-170060781 
HIGH PSI
HsaEX6016556
(LRP2)
Rat
(rn6)
chr3:55719056-55719345 
HIGH PSI
RnoEX6017280
(Lrp2)
Cow
(bosTau6)
chr2:27023233-27023519 
Chicken
(galGal4)
chr7:18301924-18302213 
HIGH PSI
GgaEX1033912
(LRP2)
Chicken
(galGal3)
chr7:20267267-20267556 
HIGH PSI
GgaEX1033912
(LRP2)
Zebrafish
(danRer10)
chr9:48889220-48889509 
HIGH PSI
DreEX6038544
(lrp2a)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TTGAAAGAGCCACACTGGGAG

				
R: 
CATCACTGCCATCACCACAGT

				
Band lengths: 
307-597

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]










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