BtaEX6038038 @ bosTau6
Exon Skipping
Gene
ENSBTAG00000040076 | ILF3
Description
interleukin enhancer binding factor 3, 90kDa [Source:HGNC Symbol;Acc:HGNC:6038]
Coordinates
chr7:16385654-16390131:+
Coord C1 exon
chr7:16385654-16385707
Coord A exon
chr7:16389036-16389401
Coord C2 exon
chr7:16390006-16390131
Length
366 bp
Sequences
Splice sites
3' ss Seq
CCTGCTGCCTTCCTGTTTAGGTC
3' ss Score
12.31
5' ss Seq
TCAGTGAGT
5' ss Score
7.68
Exon sequences
Seq C1 exon
GCGCCGGGTATGGCAGCTACGGGTATGGAGGCAACTCAGCGACTGCCGGCTACA
Seq A exon
GTCAGTTCTACAGCAACGGAGGGCATTCGGGGAATGCCGGTGGTGGCGGCGGCGGGGGCGGTGGTGGCTCTTCTGGCTACGGTTCCTACTACCAAGGTGACAACTACAACTCCCCAGTGCCCCCAAAACACGCCGGGAAGAAGCAGCCGCACGGGGGCCAACAGAAGCCCTCATATGGCTCAGGCTACCAGCCCCACCAAGGCCAGCAACAGTCCTACAGCCAGAGCCAGTACAGCAACTACGGACCCCCACAGGGCAAGCAGAAAGGCTACAATCACGGACAAGGCAACTACTCCTCGTACTCCAATTCCTACGGCTCCCCTGGAGGTGGAGGCGGATCCGACTACAGCTACGAGAGCAAATTCA
Seq C2 exon
ACTACAGTGGTAGTGGAGGCCGAAGCGGCGGGAACAGCTACGGCTCAGGCGGATCGTCCTACAACCCAGGGTCACATGGGGGCTATGGAGGTTCTGGGGGCAGCTCCTCATACCAAGGCAAACAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSBTAG00000040076-'17-27,'17-26,21-27=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.105 A=1.000 C2=1.000
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 1 annotated functions for this event
PMID: 30796096
ILF3 isoform-1 (FL) and isoform-2 (APA creating exon 18) promote cell proliferation and transformation. Tumor cells with reduced SRSF3 expression produce aberrant isoform-5 (APA and Alt3) and -7 (skipping of exon 19) of ILF3. ILF3 isoform-5 and isoform-7 suppress tumor cell proliferation and the isoform-7 induces cell apoptosis.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]