MmuEX0024059 @ mm10
Exon Skipping
Gene
ENSMUSG00000032178 | Ilf3
Description
interleukin enhancer binding factor 3 [Source:MGI Symbol;Acc:MGI:1339973]
Coordinates
chr9:21399960-21404191:+
Coord C1 exon
chr9:21399960-21400013
Coord A exon
chr9:21403136-21403501
Coord C2 exon
chr9:21404060-21404191
Length
366 bp
Sequences
Splice sites
3' ss Seq
TCTGCTGCTTCCCTGTCTAGGTC
3' ss Score
11.92
5' ss Seq
TCAGTGAGT
5' ss Score
7.68
Exon sequences
Seq C1 exon
GTGCTGGATATGGAAGCTATGGGTACAGCAGCAATTCGGCCACAGCAGGCTACA
Seq A exon
GTCAGTTCTACAGCAATGGAGGGCATTCTGGGAATGCCGGTGGTGGAGGCAGCGGGGGAGGTGGTGGCTCATCCAGCTACAGCTCCTACTACCAAGGAGACAGCTACAACTCACCAGTACCCCCGAAGCATGCTGGGAAGAAGCCGCTGCATGGGGGCCAGCAGAAAGCCTCCTACAGCTCGGGCTACCAGTCCCACCAGGGCCAGCAGCAACCTTACAACCAGAGCCAGTACAGCAGCTACGGCACGCCACAGGGCAAGCAGAAAGGCTATGGCCATGGGCAGGGCAGCTACTCCTCCTACTCCAACTCTTACAACTCCCCAGGTGGTGGTGGGGGCTCTGACTACAGCTACGACAGCAAATTCA
Seq C2 exon
ACTACAGTGGGAGTGGAGGCCGGAGTGGAGGCAACAGCTATGGCTCCAGCGGGTCATCGTCCTACAACACAGGCTCACATGGAGGCTATGGCACAGGCTCCGGAGGCAGCTCTTCATACCAAGGCAAACAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000032178-'43-49,'43-46,60-49
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.056 A=1.000 C2=1.000
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GTGCTGGATATGGAAGCTATGGG
R:
TGTTTGCCTTGGTATGAAGAGCT
Band lengths:
184-550
Functional annotations
There are 1 annotated functions for this event
PMID: 30796096
ILF3 isoform-1 (FL) and isoform-2 (APA creating exon 18) promote cell proliferation and transformation. Tumor cells with reduced SRSF3 expression produce aberrant isoform-5 (APA and Alt3) and -7 (skipping of exon 19) of ILF3. ILF3 isoform-5 and isoform-7 suppress tumor cell proliferation and the isoform-7 induces cell apoptosis.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types