DmeEX6012886 @ dm6
Exon Skipping
Gene
FBgn0086408 | stl
Description
The gene stall is referred to in FlyBase by the symbol Dmelstl (CG3622, FBgn0086408). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (1 unique). Gene sequence location is 2R:22807860..22815993. Its molecular function is described by: metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: oogenesis; ovarian follicle cell development; negative regulation of neuron migration; proteolysis; ovarian follicle cell stalk formation. 12 alleles are reported. The phenotypes of these alleles manifest in: stalk follicle cell; germline cell; lch1 neuron; cellular anatomical entity; larval abdominal sensory neuron. The phenotypic classes of alleles include: cell migration defective; decreased cell number; female sterile; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages, in adult female stages.
Coordinates
chr2R:22813601-22814892:+
Coord C1 exon
chr2R:22813601-22813729
Coord A exon
chr2R:22813787-22814036
Coord C2 exon
chr2R:22814097-22814892
Length
250 bp
Sequences
Splice sites
3' ss Seq
TATTGAAATATCTATCTTAGGGA
3' ss Score
5.96
5' ss Seq
ATGGTAAGT
5' ss Score
11.01
Exon sequences
Seq C1 exon
TTTGGGAATGCGACACGATGCCAAGGAGATTAGCTGCGATCCTACCATGCACATCATGTCCCCGAAGCTGGGCAGCGGCAAGGTCACCTGGTCCAAGTGCTCGCGCACCTATCTTGAGGATTTCCTAAT
Seq A exon
GGATCCCCAGGCAGAGTGCCTCTTCGATCGGGACTCGTTCGCGGGTCCTTGGGATCATACGGCAGGTGGTCGTCTTCCTGGCGAACGTTTCAATGCCAATCAGCAGTGCATGCTGCGCTTTGGGAAGAACTTCATGCAGGCTAGCACCCAGAGCAAGATGGAAATCTGTCGGGATCTCCACTGTCGCCAGGATGGACTGCCCTGGACTTCGCATCCGGCGCTGGAGGGAACCGAATGCGGCCCCAACATG
Seq C2 exon
TGGTGCCGAGGTGGAACCTGTGAGGCACGTTCCTCCAAACAGGGCAGCTACTCAGCCCTCAAGTCCTGGCCTCCTGAACATATTCCCGAGGCCACCCACGAGAAGATTATCCGACATGAGCCGAACAGGATTCCCCCGCTGCTGCACGACTACAATCCGATGGATAATGAGCTGCCAGGATCGCCCTCGAATTGGGGCGAGTGGAGCGAGCCGAGTGCCTGTGAGTCCGGCTGCCTCTACGGGCAGTCACGCCGCCTCCTGGAGGGCAGCACAGGTCTCCGAACGTTGAACAGAAGCTGCCTGAACTTTCCATCGCGCTGCATTGGCAGGGATCGGCGATTTGTCACCTGCAACACACCGCAATGCCACAAGGTGCCCGTCCAGACAATCAACGACTTTGCCACCCAAGTGTGCATGCAGGCGAGGAAGTCGGATCCGGAACTCACCGGCGAGGGCCAGCAGCTGCCCAGCACGCTGGACGCGTCCTGCAAGATCTTCTG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0086408-'5-6,'5-5,6-6=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.060 C2=0.361
Domain overlap (PFAM):
C1:
PF0142114=Reprolysin=FE(19.9=100)
A:
PF0142114=Reprolysin=PD(5.1=13.1)
C2:
NO
Main Inclusion Isoform:
FBpp0112023
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0301591
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg19)
No conservation detected
Chicken
(galGal3)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ATGCCAAGGAGATTAGCTGCG
R:
GCGATCCTGGCAGCTCATTAT
Band lengths:
296-546
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)