HsaEX0014017 @ hg38
Exon Skipping
Gene
ENSG00000158402 | CDC25C
Description
cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727]
Coordinates
chr5:138319219-138326054:-
Coord C1 exon
chr5:138326021-138326054
Coord A exon
chr5:138325815-138325904
Coord C2 exon
chr5:138319219-138319374
Length
90 bp
Sequences
Splice sites
3' ss Seq
CAGCAAACTCTCTTTTTTAGGCA
3' ss Score
6.59
5' ss Seq
AATGTGAGT
5' ss Score
7.8
Exon sequences
Seq C1 exon
GAATCATGACCAGCACCTAATGAAATGTAGCCCA
Seq A exon
GCACAGCTTCTTTGTAGCACTCCGAATGGTTTGGACCGTGGCCATAGAAAGAGAGATGCAATGTGTAGTTCATCTGCAAATAAAGAAAAT
Seq C2 exon
GACAATGGAAACTTGGTGGACAGTGAAATGAAATATTTGGGCAGTCCCATTACTACTGTTCCAAAATTGGATAAAAATCCAAACCTAGGAGAAGACCAGGCAGAAGAGATTTCAGATGAATTAATGGAGTTTTCCCTGAAAGATCAAGAAGCAAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000158402-'6-17,'6-16,8-17
Average complexity
C1
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.500 A=0.700 C2=0.639
Domain overlap (PFAM):
C1:
PF066178=M-inducer_phosp=FE(16.9=100)
A:
PF066178=M-inducer_phosp=FE(44.6=100)
C2:
PF066178=M-inducer_phosp=PD(4.6=5.8),PF066178=M-inducer_phosp=PU(42.9=98.1)
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AGCACCTAATGAAATGTAGCCCA
R:
TGCTTCTTGATCTTTCAGGGAA
Band lengths:
176-266
Functional annotations
There are 1 annotated functions for this event
PMID: 11842186
Partially encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: competition binding, mutation analysis. ELM ID: ELMI001012; ELM sequence: NKEND; Overlap: PARTIAL_RIGHT
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- The Cancer Genome Atlas (TCGA)
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development