HsaEX0014018 @ hg38
Exon Skipping
Gene
ENSG00000158402 | CDC25C
Description
cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727]
Coordinates
chr5:138291970-138325904:-
Coord C1 exon
chr5:138325815-138325904
Coord A exon
chr5:138319219-138319374
Coord C2 exon
chr5:138291970-138292116
Length
156 bp
Sequences
Splice sites
3' ss Seq
GTTGTCAATATACTTGACAGGAC
3' ss Score
3.98
5' ss Seq
AAGGTAAAG
5' ss Score
9.06
Exon sequences
Seq C1 exon
GCACAGCTTCTTTGTAGCACTCCGAATGGTTTGGACCGTGGCCATAGAAAGAGAGATGCAATGTGTAGTTCATCTGCAAATAAAGAAAAT
Seq A exon
GACAATGGAAACTTGGTGGACAGTGAAATGAAATATTTGGGCAGTCCCATTACTACTGTTCCAAAATTGGATAAAAATCCAAACCTAGGAGAAGACCAGGCAGAAGAGATTTCAGATGAATTAATGGAGTTTTCCCTGAAAGATCAAGAAGCAAAG
Seq C2 exon
GTGAGCAGAAGTGGCCTATATCGCTCCCCGTCGATGCCAGAGAACTTGAACAGGCCAAGACTGAAGCAGGTGGAAAAATTCAAGGACAACACAATACCAGATAAAGTTAAAAAAAAGTATTTTTCTGGCCAAGGAAAGCTCAGGAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000158402-'8-22,'8-17,11-22
Average complexity
C1
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.700 A=0.639 C2=0.519
Domain overlap (PFAM):
C1:
PF066178=M-inducer_phosp=FE(44.6=100)
A:
PF066178=M-inducer_phosp=PD(4.6=5.8),PF066178=M-inducer_phosp=PU(42.9=98.1)
C2:
PF066178=M-inducer_phosp=PU(71.6=98.0)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACAGCTTCTTTGTAGCACTCCG
R:
CTTCCTGAGCTTTCCTTGGCC
Band lengths:
235-391
Functional annotations
There are 5 annotated functions for this event
PMID: 11842186
Partially encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: competition binding, mutation analysis. ELM ID: ELMI001012; ELM sequence: NKEND; Overlap: PARTIAL_LEFT
PMID: 11897663
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: alanine scanning, inhibitor. ELM ID: ELMI002160; ELM sequence: EISDELMEFSLKDQE; Overlap: FULL
PMID: 11897663
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: alanine scanning, protein kinase assay. ELM ID: ELMI003363; ELM sequence: MEFSLKD; Overlap: FULL
PMID: 12738781
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: alanine scanning, electrophoretic mobility shift assay, protein kinase assay, western blot. ELM ID: ELMI003363; ELM sequence: MEFSLKD; Overlap: FULL
PMID: 14968113
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: alanine scanning, coimmunoprecipitation, mutation analysis, protein kinase assay. ELM ID: ELMI003380; ELM sequence: EEISDEL; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development