HsaEX0043401 @ hg19
Exon Skipping
Gene
ENSG00000074181 | NOTCH3
Description
notch 3 [Source:HGNC Symbol;Acc:7883]
Coordinates
chr19:15280897-15281636:-
Coord C1 exon
chr19:15281482-15281636
Coord A exon
chr19:15281142-15281364
Coord C2 exon
chr19:15280897-15280981
Length
223 bp
Sequences
Splice sites
3' ss Seq
CCTCTGCTTCCTGCTCTTAGGGG
3' ss Score
9.97
5' ss Seq
GAAGTGAGA
5' ss Score
3.22
Exon sequences
Seq C1 exon
CTCGGTAGTAATGCTGGAGATTGACAACCGGCTCTGCCTGCAGTCGCCTGAGAATGATCACTGCTTCCCCGATGCCCAGAGCGCCGCTGACTACCTGGGAGCGTTGTCAGCGGTGGAGCGCCTGGACTTCCCGTACCCACTGCGGGACGTGCGGG
Seq A exon
GGGAGCCGCTGGAGCCTCCAGAACCCAGCGTCCCGCTGCTGCCACTGCTAGTGGCGGGCGCTGTCTTGCTGCTGGTCATTCTCGTCCTGGGTGTCATGGTGGCCCGGCGCAAGCGCGAGCACAGCACCCTCTGGTTCCCTGAGGGCTTCTCACTGCACAAGGACGTGGCCTCTGGTCACAAGGGCCGGCGGGAACCCGTGGGCCAGGACGCGCTGGGCATGAA
Seq C2 exon
GAACATGGCCAAGGGTGAGAGCCTGATGGGGGAGGTGGCCACAGACTGGATGGACACAGAGTGCCCAGAGGCCAAGCGGCTAAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000074181-'27-28,'27-27,28-28
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.057 A=0.347 C2=0.552
Domain overlap (PFAM):
C1:
PF076847=NODP=FE(80.0=100)
A:
PF076847=NODP=PD(13.8=12.0)
C2:
NO
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CTCGGTAGTAATGCTGGAGATTGAC
R:
GGCACTCTGTGTCCATCCAGT
Band lengths:
220-443
Functional annotations
There are 1 annotated functions for this event
PMID: 16530045
This event
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: inferred by author. ELM ID: ELMI002959; ELM sequence: LWFP; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)