HsaEX6062953 @ hg19
Exon Skipping
Gene
ENSG00000119408 | NEK6
Description
NIMA (never in mitosis gene a)-related kinase 6 [Source:HGNC Symbol;Acc:7749]
Coordinates
chr9:127089617-127110101:+
Coord C1 exon
chr9:127089617-127089724
Coord A exon
chr9:127101850-127101944
Coord C2 exon
chr9:127109988-127110101
Length
95 bp
Sequences
Splice sites
3' ss Seq
CGCCCCTTGCTGTGTTGCAGTGG
3' ss Score
8.05
5' ss Seq
GAGGTGAGT
5' ss Score
10.03
Exon sequences
Seq C1 exon
ACATCAAGCCTGCCAACGTGTTCATCACAGCCACGGGCGTCGTGAAGCTCGGTGACCTTGGTCTGGGCCGCTTCTTCAGCTCTGAGACCACCGCAGCCCACTCCCTAG
Seq A exon
TGGGGACGCCCTACTACATGTCACCGGAGAGGATCCATGAGAACGGCTACAACTTCAAGTCCGACATCTGGTCCCTGGGCTGTCTGCTGTACGAG
Seq C2 exon
ATGGCAGCCCTCCAGAGCCCCTTCTATGGAGATAAGATGAATCTCTTCTCCCTGTGCCAGAAGATCGAGCAGTGTGACTACCCCCCACTCCCCGGGGAGCACTACTCCGAGAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000119408-'17-22,'17-20,21-22=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF0006920=Pkinase=PD(21.5=94.6)
A:
PF0006920=Pkinase=FE(11.8=100)
C2:
PF0006920=Pkinase=PD(16.3=93.3)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCAACGTGTTCATCACAGCCA
R:
CACTGCTCGATCTTCTGGCAC
Band lengths:
170-265
Functional annotations
There are 1 annotated functions for this event
PMID: 16476580
This event
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: coimmunoprecipitation, glutathione s tranferase tag, pull down. ELM ID: ELMI002027; ELM sequence: YYMSPE; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)