HsaEX6064123 @ hg38
Exon Skipping
Gene
ENSG00000159069 | FBXW5
Description
F-box and WD repeat domain containing 5 [Source:HGNC Symbol;Acc:HGNC:13613]
Coordinates
chr9:136942547-136943506:-
Coord C1 exon
chr9:136943349-136943506
Coord A exon
chr9:136942769-136942943
Coord C2 exon
chr9:136942547-136942695
Length
175 bp
Sequences
Splice sites
3' ss Seq
CAGCCGCCCCTGCCGAACAGATC
3' ss Score
5
5' ss Seq
TAGGTGAGC
5' ss Score
7.96
Exon sequences
Seq C1 exon
CGGCCATGTCCTGGTACGAGGAGTTCCAGCGGCTGTATGACACGGTGCCCTGCGTGGAGGTGCAGACGCTGCGGGAACACACAGACCAGGTCCTGCACCTCAGCTTCTCCCATTCCGGGTACCAGTTCGCGTCCTGCTCCAAGGACTGCACTGTGAAG
Seq A exon
ATCTGGAGCAACGACCTGACCATCTCGCTGCTGCACAGCGCGGACATGCGGCCCTACAACTGGAGCTACACCCAGTTCTCCCAGTTCAACAAGGACGACTCGCTACTGCTGGCCTCGGGGGTGTTCCTGGGGCCGCACAACTCCTCATCCGGCGAGATTGCTGTCATCAGCCTAG
Seq C2 exon
ACTCCTTCGCGCTGCTGTCCCGCGTGCGGAACAAGCCCTATGACGTGTTTGGCTGTTGGCTCACCGAGACCAGCCTCATCTCGGGGAACCTGCACCGCATCGGAGATATCACCTCCTGCTCGGTGCTGTGGCTCAACAATGCCTTCCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000159069-'3-16,'3-14,6-16=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF0040027=WD40=PU(89.7=66.0)
A:
PF0040027=WD40=PD(5.1=3.4)
C2:
NO
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Mouse
(mm9)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GAGTTCCAGCGGCTGTATGAC
R:
GGAGGTGATATCTCCGATGCG
Band lengths:
254-429
Functional annotations
There are 1 annotated functions for this event
PMID: 21725316
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: alanine scanning, coimmunoprecipitation, protein kinase assay, western blot. ELM ID: ELMI003387; ELM sequence: KDDSLLL; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains