HsaINT0041225 @ hg38
Intron Retention
Gene
ENSG00000134376 | CRB1
Description
crumbs 1, cell polarity complex component [Source:HGNC Symbol;Acc:HGNC:2343]
Coordinates
chr1:197421000-197428001:+
Coord C1 exon
chr1:197421000-197421956
Coord A exon
chr1:197421957-197427453
Coord C2 exon
chr1:197427454-197428001
Length
5497 bp
Sequences
Splice sites
5' ss Seq
GAGGTGAGA
5' ss Score
7.66
3' ss Seq
CCTCTATTTTGACATTGAAGAGT
3' ss Score
2.73
Exon sequences
Seq C1 exon
GAATCCACTGCGAAGAAGACGTCAATGAATGTTCTTCAAACCCTTGCCAAAATGGTGGTACTTGTGAGAACTTGCCTGGGAATTATACTTGCCATTGCCCATTTGATAACCTTTCTAGAACTTTTTATGGAGGAAGGGACTGTTCTGATATTCTCCTGGGCTGTACCCATCAGCAATGTCTAAATAATGGAACATGCATCCCTCACTTCCAAGATGGCCAGCATGGATTCAGCTGCCTATGTCCATCTGGCTACACCGGGTCCCTGTGTGAAATCGCAACCACACTTTCATTTGAGGGCGATGGCTTCCTGTGGGTCAAAAGTGGCTCAGTGACAACCAAGGGCTCAGTTTGTAACATAGCCCTCAGGTTTCAGACTGTTCAGCCAATGGCTCTTCTACTTTTCCGAAGCAACAGGGATGTGTTTGTGAAGCTGGAGCTGCTAAGTGGCTACATTCACTTATCAATTCAGGTCAATAATCAGTCAAAGGTGCTTCTGTTCATTTCCCACAACACCAGCGATGGAGAGTGGCATTTCGTGGAGGTAATATTTGCAGAGGCTGTGACCCTTACCTTAATCGACGACTCCTGTAAGGAGAAATGCATCGCGAAAGCTCCTACTCCACTTGAAAGTGATCAATCAATATGTGCTTTTCAGAACTCCTTTTTGGGTGGTTTACCAGTGGGAATGACCAGCAATGGTGTTGCTCTGCTTAACTTCTATAATATGCCATCCACACCTTCGTTTGTAGGCTGTCTCCAAGACATTAAAATTGATTGGAATCACATTACCCTGGAGAACATCTCGTCTGGCTCATCATTAAATGTCAAGGCAGGCTGTGTGAGAAAGGATTGGTGTGAAAGCCAACCTTGTCAAAGCAGAGGACGCTGCATCAACTTGTGGCTGAGTTACCAGTGTGACTGCCACAGGCCCTATGAAGGCCCCAACTGTCTGAGAG
Seq A exon
GTGAGAGAAAGCTGAGTGCTATGGCTAGGAGTGCCATGCCTCAGAGCAGAGCAGAAACAGCAAAAACAGCCAGACTGCTTCTGCCTGCTATGAAACATAATGACCCCACAAGACTTCTGCTGCTGGTTGCCCACTGATGAGAAAGAAAAGAAGAGGGCAGTGATGTGCGTTAATTAATTTTGAGTGGATTCATAGGACATCAGTTTCACTCATACAGAGAAGTAAAAAAAATAAGCAGATAGCTCTTTTCCAAAGAGGTTTTCATCTTTGTGTTTGCAAAATGCTACTGCAATTTTACCATTGGTCACATATCAGAAATTTATTGTAAATCTTATTTGAAAGAGAAATAATCTTTTGAAAAAAAAAAACCTTAGACATAAAATTTGTCAGTGCCACATACTAGCATGATATCTTGTGCATAGTAAATTCTCGGTAAATATTCATTTCCTTGCTCTCCTTTCCATGCAATTCACACTTGCTCCACAATCATAATTAAGCATAGCGTTTTTATAAAACGCCAATTTTATTCAAAGGTATCTTTTCCAAGGTTGCCCTGGAGAAGACAGATAATATACTAGGTGTCTTAAGAAAAAAAAAAAAGAAAAAAAAATGTGGAAAGTAACAATAGTAGAACTTGGTAGATGCCATAAACTAATTGATCTAATTTCTCTAGTAAACCACAGTTTGCAAAGTATTTCAAAATCCTTAACTTCCAACATTGTTCTAGAGATTGCTGTTGATAGTGATCAATATATACCTGTTTCTTTTTATTATTATTATCATACATTGAAAAAGTCTGAGAGGTAATTGTAACGGACTGCTTTGAAGTTCAGCTGTAATTTACCCCAAGATTTTAGAGTAACTTGAAGTAGGACAACATCTGGTAAGTAGTCTTCTCTGCTTTATATGAAGTAAAATTAAAACCAGTCTTAGCCTATACTCTATTCCATGTTCAAATGTCTAAGAATTATTAGAAACTACTCAAGGGTTTCCCCCGACCACAATATTCATTACAAATCACGGACCTGTTTGACAATGAAGTATGGTATCTACTAGCTCTACGTAATATTTTAAGTAGAATGGCAAGTTGTTTTGTGATTTTTTTTAAGGAGAAAAAGGGAAATTATGCTGAGGCAATGTTCACTTTTTGAAGAAAAATTTAATTGACCTAAGGCAATATTTTTACTACATATACAAAATAACAAACAGATGCTGACTCATTTTGACTGGCTTCCAGATGCAGTGACCCATGAGGTTAATACTGACCATGGTGATGTTAACTGTCCTAGTAAATAGATTCAAGAGATGCCAATCCACTGGGTTCTGGTTTTCTTTATTTTATCCAACTTGGAAAACCATGAACTTTTCAAACCAAGTTCCTGAATTGGTTACCCTTCCCCCACTTCTCCCAGTTTCCTTATACTCCAACATTATTTGAAACTGCTTAACCCTCAAGAAAATATTTGACTTCAAAAGATCACTTTACAGACAGAGAGAGTTCTGTGAAATCTTTTCTTTCTGAAAATTCTTGGTATAAATTTAAGGAAAATTATATTTTTCATATCACCTCTTCATTATAAAATTAAAATATTCTGTATTTTCTGTTATCTTGAAGGAATGTTTCCTGGAGAGTTTATTCCCACTAAAAACTGCTTTTAAGTGGTAATGAGAACATGGAGTCTTTCTGCTACTGTACATATACGTGCAAGAGGGAGGAGACATACTAAAAAGCACAAAGGCAAACTTCAGCCCATTCATGACTTGCACTCATATTTGGCTCAATGTTTTCCAACCATGGTATACATTTTAATGAACAAGGAGACTGGATAGAGGATTTTGGTGGCTGACTAAACACAAAAGACATAGTGATTTCCAATGTATCAAGGTTGATCTTTTTTAAATAATCTAATTTCTCAACAGAAAGAGTGCTGAAAAGGATTTAACTAAGCTTAGGTCACAGAAGTGTCCATAAGGTTCTCTCAGCATATCTTGTGTTGACTGTTTGTAAGAACATGCAGCATTCAAGATACTACTACTCAGAATAAATGGCATCACCTACCTCTTGCTCTCTGGTGAACATTTGACTTACAAAAGCAATTTACATATCTCTTCTTTTCAGCCATATACCTAGATTTTGAGAATTTTATTCTCTTAGAATTATAGTTTCCTAGATATAGAAAAAGATTCATTCTATGACTGAATTTTTAACACAATTGTACCTGCCAAATGTAGTGGCTCAAATCTCTGCTCAAACACCTTCACAAATAGAGAGATCACTCACTCCATCTTGCCAAAAATTGCCCAAAAGTTATTTCCTTATATTGAAATAGAATAGGATTTGCCCGTAGCTTTCCTTCATTGACCTTGTTGCATTTCTGGAACACATGCAAATAAAAATCTCAACTTGCCTGCTGCTTGAGAATACTTAATATCTGAAGAAAAGTATCTCGAGCCATCTAAACCATCACTTCTATTCAGGCTAAACATCCTGTTTCTTCTAATGTTTGCCATATGACATAGTTTTCCGACACTTCATCAGCTGCTTGCAGGTTTTGGAATATATTTGCTTCTTTGTATTCCTTCTAAGATGTGATGTCTGTATGTGCTGGATGATACAGTGACACACAGGGCCATAACCTCCCTTATTCTAGATAATGTGCTTCTGTTTTTCAGCTTAATACAACATTGACTTTTTGGCAGCCACACTTCGTGATTGCGTCACTTTGTATCATTGTCACTCATGATGCCACATAGTCCTGTTTCTCCCACTCTAATCTTATAAACGCACATTTAGATCGAAGTGGCTCTTATTTATTCTTGTTAAATTTCATCTTGTTGTATTCCATCAATCATTAAAGCTTGCCAAAATTGTTTTTTATCTGTATGTGTTGTTCCTCTTCATGACATGTCAACCACTTGTATGAGTATCACCCTTCCAAATCCACAGCCAAGTCATATGTCTTCAGGTGTTTCTAAAGTCATGTAGCAAATCACACATGCTGATTAGTTGCTTGTGATTTCTGAGAAATAGGATTGCTGAAGAATCAGGCTTCTGAGAAAAAAAAATACTCTGCATTTTGGCTTTTAATCCAGATCCACAAAGTGATGCTGAAGGCATCCTGGGATGACCAGCAGGCACCCCGCTACCCCTGAGGTTGAGTGATTCTGGGCATATCTTCAAACCTCAGGGGCTTCAAGGGCCAAATTTTCTTATTAAGCATTTTATCTCATATGAAAGTGCTGCAGTGTATTCAGAGATGTTAACCTCTTCAAAGGGGTTATTTTATCTAACAGTACACTTTTGAAAGCTACCGGTAGTTGCCTGGAGCAGGTGGTCTCCAAATGCAGATTCAAAATGCAATGTTCCTGTATTAAATCAAGTCAGAGTTCTGAAAATATAGCCTTTTATGCAGAAGATCTTCAAACACAGTTGATTGTCTAAGCAAGTTTTACTATAGTTAAGCTAAACTAAAATGTGTCTTACCTTTGCCCAAACTTCAGCTGGGCCATATGATGACATTTAGACATGCTGAAATATGCTCTTTTTTTCTGGTTAGTACTGGGATATAAAATCTTGAAGACAGCAATATCTTGAAGACAGTGATCTTGTCAAGTTATCAATGCTTTCTAGACTGCAAAATCAATGGTCAATTCTGTCCCCATCTTACTTGATTTCTCAATACCAGTTAACACAATTAAACACTCCCTCCTCCTGAAAAACTATTTTCTCACTAGGCTTATGGGACACCACACTCCCTTGGTTCTCCTCTTATCTTACTGGCTACTCTTGCATCATTTCCTTTACCTCTACTTGTCTAATGCCCAAGGACTTACTTCTTGGACCTCTCATTTTCTCTATATATACTCATTCTCTTGGTGATCTCATCCAGTCTTGTGGCTCTAAATATCTAATATGGTTTGGATGTATGCCCCCTCCAAATCTCATGTTGAAATGTGATTCCCAATGTTGAAGGTGGGGCCGATGGAAGGTGGTATATACTAACAAATCCCACATTATCAGAACATCCTGCCTGAACCTCTATATCAACTGCCCACTAGTCACTTCTGCTTGGATATCCAAAAAGGCATCTCAAATTTAATATGGACTCCCACCTCACCCAAAAATCTTTTCCTCCAGTTTTCTTCCGTATCTCTGCAAATAGAAAGTCCATGCTTCCAGTTGCTTAGGCCCAAAGCCTTAGAGATGAACTTGCTCCAGAAAATTCTGTTGTATCTACCTTCAAAATATTTTGAAAATCTGACCACTTTTGACCACTTTCACATTACCACTGATCCAAGCCATTATCATTTCTCTCTTGAGTTGCTACAATAATGTAGTATAACTTTGGGCTTTTGCTCAGATATCACTTTCTCAGAGTTCCTCCCTGATTGTTCTATTTAAAATTACAATTCCACCCCTCCAAATCGCCCTATTCCCTTTCTCTACCTGACATTTTATACTAAAGGATTTCTCACCATCTGACATATTATATAGTTTGCTTCCTTGTCTGTGTCTGGTGTCTTTCCTCCAACTAGAATGTAAGCTTGATGAGGATGGGAAGTTTTCTTCCTACTATGTCACCCATATTTTACAATGTCAGTTTTTATTTTTATACATCTCAAGAGTTTTCTTGAGGTGATGCACATCAATAGCATTGCCACAGATGAGCATCACTAACTCCTCTGACCACAGGAAATGCAGGGTGGGTTTAATACTCAGCTTTGCCCCAAGTTCTCTGTTTCCTGTGCCTTTCCTACTCCCAACCAGGACCACAGAAGGAAGGGTCCTTCTTTTTCCTTGTTCAACTGCCTTGCTTCTTATGTGAGATGTCATCCCAAGAGAAGATTTAATCATCTAATTCTTGATTTCTGTTGTCCCAATTTATGTTATTTACAGACTAAAAACCTGAAGTTTAGAAAGGTTATGTAACTAGCCTAAATCACATGTTAATAGCAGACCTGGGACAAATACATTCCAGGCTCTAAAAAATTTCTTTACAAAGAATAATTAGGTTTAATGACATGTTTGCTTCAGCATGCCTCTAAGTAGCAAAGATTATGACTCCCTGCACAGTCCACTTGCAGAGGGTTGCATGAAGTGCCCTTGTCCAAAAATTTCTTCCACCAGGTTGGAGTATAGTAGTGTCTGATATACCACCATTAAGGCCCATATTTTAGGGCAGCAAAGGGGAGATTCTTTAGTTTATCAGTGCAGAGATCTTTTTGGTCTGTTTTGTGATCAATATGCCTGAAGTGTAAACTACAAACCAAAATATAGTTATTTTAGGGTTAAAGTAAACTCAGAAGTCCAGAAAGAGGCCAAATCATTATTCTATTTAATAAACCTGTCCTGAACTTTAAAAGCTATGTATGAGTGTGTATGCTTGTGTGCATGTGTGTGTGTGAAATGTATAATTTTCGTCTTCCATCCCTTCTGTCTTTTGAGCCTTAAGATGTTTCTTTTTTTTTCTCCTCCTCCTCTATTTTGACATTGAAG
Seq C2 exon
AGTATGTGGCAGGCAGATTTGGCCAGGATGACTCCACTGGTTATGTCATCTTTACTCTTGATGAGAGCTATGGAGACACCATCAGCCTCTCCATGTTTGTCCGAACGCTTCAACCATCAGGCTTACTTCTAGCTTTGGAAAACAGCACTTATCAATATATCCGTGTCTGGCTAGAGCGCGGCAGACTAGCAATGCTGACTCCAAACTCTCCCAAATTAGTAGTAAAATTTGTTCTTAATGATGGAAATGTCCACTTGATATCTTTGAAAATCAAGCCATATAAAATTGAACTGTATCAGTCTTCACAAAACCTAGGATTTATTTCTGCTTCTACGTGGAAAATCGAAAAGGGAGATGTCATCTACATTGGTGGCCTACCTGACAAGCAAGAGACTGAACTTAATGGTGGATTCTTCAAAGGCTGTATCCAAGATGTAAGACTAAACAACCAAAATCTGGAATTCTTTCCAAATCCAACAAACAATGCATCTCTCAATCCAGTTCTTGTCAATGTAACCCAAGGCTGTGCTGGAGACAACAGCTGCAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000134376:ENST00000484075:6
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0000822=EGF=PD(3.9=0.6),PF0000822=EGF=WD(100=7.5),PF0000822=EGF=WD(100=10.9),PF0221019=Laminin_G_2=WD(100=43.1),PF0000822=EGF=WD(100=9.7)
A:
NA
C2:
PF0221019=Laminin_G_2=WD(100=64.5),PF0000822=EGF=PU(3.3=0.5)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development