HsaINT0049365 @ hg38
Intron Retention
Gene
ENSG00000105877 | DNAH11
Description
dynein axonemal heavy chain 11 [Source:HGNC Symbol;Acc:HGNC:2942]
Coordinates
chr7:21892425-21894805:+
Coord C1 exon
chr7:21892425-21892667
Coord A exon
chr7:21892668-21894622
Coord C2 exon
chr7:21894623-21894805
Length
1955 bp
Sequences
Splice sites
5' ss Seq
AAGGTAGAG
5' ss Score
6.38
3' ss Seq
CTTTGTGTTACTGATTTAAGGTT
3' ss Score
6.79
Exon sequences
Seq C1 exon
ACTGAAGATGAACTGATGCTGGCACCAGGTTTTGCTGCCCCACCCTACCTAGATTATGCAGGCTACCACCAGTACATAGAGGAGATGCTTCCTCCAGAAAGCCCGGCACTGTATGGCCTCCACCCAAATGCTGAAATAGAATTCCTGACAGTGACATCCAACACTCTCTTCAGAACTTTGCTGGAGATGCAGCCCAGGAATGCACTCAGTGGTGATGAACTGGGGCAGTCTACAGAAGAAAAG
Seq A exon
GTAGAGGGTCTTTCCTTCCTTTTCTTTTTCATTGAAGTATAACTTACTTGTACTGAAGTCTACTAATCTTAATTGTGCAAATCAATAAGTTTTTACCTAGGTTTTACTCATACAACCACCACCTAGATCAAAATAACATTTCCAACACTCCAGAAGGATACTCATGCCCCTTATCAGTCAACATACCCCTCACCTCCCCCAGAGATAATCAGTATCTTTACCTCTATCATCACAGATTAGCTTTACCTGATTCCAAATATATGGAATCATACAGTGCGCATTCATCCATGTCTAACTCCTTTCATTCTGCATTAGATTTGTGAGATTCATCCATGTTGTTCATGTACCAATGGTTCATTTTTGTTTTGAATTCTATATGAATATAAAATTCTTCATTGTACTGTGAATGGATGTTTGGGTTGTTTCTTGTTTTTCACTTTTATAGAAATATCACAACCATGAACATTCTTCTGCAGTCAATATGCAAAGGTAACTCCCAAAGGCATCCATTCATACTACCCATTTCTCTATACCCAGAAGTGGGATTGCCAGATAACAGGGTATAATGTGTAGCTTTAATAGTATTCCCAATCAGTTTTCTCCAGTGGCTGTACCAGTTACTTTCCCACCAGCAGTGCGTGTGAGTTCCACTTGCTCTATCTTTTTTGTGATTTTGTAAGGGTAATGATATCTCACAGTGGTTTTAATTTTGCAATCCTCAATTGAGGAGTAATATTGAGCATCTTTTCACATGCTTATGGCCGTTTGGATATACTGTCTACCTCCACTGTAAATGAGTTTAAGATTTCAGGACCTGATAAATTGCCGGTCAGAGTGATGCCAGCTGGCAGGCATGATGTCAGAACCAGAGGCAGTAGTCTGAGAAAGCAAGGAAAGAAGGAAAGCTGCCTGAGGCTAAGGACAGGCAAAGTTCCTCCATCTTTTCTCCTTTCTAGATATTGACTGGTTTTTCCAGCTCGGTGGAGCTGTCTACATAGAATTAGTATGCATGTCTGAGTACCATGTGCATACTCATACCTGTAATATATGTCTTTCATTCTTTCAGAGCAACAATTACAGAAGATAGAAGTTTCTTTGTTAAAAATGTTGATGTAAATTGGTCTAGGAATTTTAGGATGCCGTGGTTGGGAGGGCAGCATCATAGTTCAGCAGAATTTGCTTACGCTTAAAAGGCTTATTTGGGTTATGTGACTTTTATTCTATTTTATTTTTTATTTTTTGAGACAGTTTCATTCTGTTGCCCAGGCTGGAATGCAGTGGCACCATCTTGGCTCACTGCAACCTCTAACTCTCGGATTCAAGCGATTTTCGTGCCTCAGCCACCCAAATAGCTGGGATTACAGACATGCTCCAACATGCCTGGCTAATTTTTATATTTTTAGTAGAGACAGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTCAAGCGATCTGCCCATCCTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCAGCCCCTGGTTTGTGTGGCTTTTAAAAGGATCTTTTTAATTTAGCAGATTATAAAATATGGTACCCTAATAATAGGCTTCTACTTCCTCTGATCATATCTTTACATATAAATAACATGTAGCTGATGACAGTTCTATACTCCCTAAATGTTAAGTGAGTAAACTGCAAACAACTGTAGCTCCTTCTTGACCAGATTTGGGGCTCCATGGAAGGGGAAGTGCTGGCACTGGTACAGAGGCACCAATGAGGCAGCTGAGGGAGTTGGCACTGCCATGCTGCCCACCTCCTGGGAGCCGTAGGCATCCTTCACATGCATTTGCAGGCACCTTCGGAAGTCGTATGATATATTCTGTAACTTCAAAAAGTAGAGGATATACACAGTCACCATGACGAAAACTGAAATAGAAAGGAGCTAAATCTTTGTGTTACTGATTTAAG
Seq C2 exon
GTTAAGAATGTCTTGGATGACATTTTGGAGAAACTTCCAGAAGAGTTCAACATGGCAGAGATAATGCAAAAAAATTCAAATAGAAGCCCATATGTTCTTGTTTGCTTCCAAGAATGTGAGAGGATGAATATTCTCATTCGGGAAATACGTATATCACTTGAACAACTGGACCTTAGTTTGAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000105877:ENST00000409508:77
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.086 A=NA C2=0.016
Domain overlap (PFAM):
C1:
PF0302810=Dynein_heavy=FE(11.4=100)
A:
NA
C2:
PF0302810=Dynein_heavy=FE(8.5=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal3)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CTGATGCTGGCACCAGGTTTT
R:
TCCTCTCACATTCTTGGAAGCA
Band lengths:
355-2310
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development